3 research outputs found
Role of immunohistochemical markers in evaluating malignant transformation of oral submucous fibrosis: A systematic review
Get PDFObjective(s): We present a systematically to identify, evaluate and assess the role of Immunohistochemical markers in Malignant Transformation of Oral Submucous Fibrosis (OSF). Materials and Methods: Extensive literature search was done to identify eligible through “MEDLINE”/ “PubMed”, “Scopus” and “Cochrane library” were searched for relative studies until December 2021. The included studies were published in English language were mainly retrospective original research\.These studies mainly evaluated the role of Immunohistochemical markers in Malignant Transformation of Oral Submucous Fibrosis. Results: Thirteen studies were included in the present study which had total of 549 cases. Most of the studies suggested use of combined biomarker model or panel of antibodies to minimize the risk of bias. Almost all the studies used ANOVA and chi-square test while kappa test analysis for interobserver variability test. Conclusions: The significance of immunohistochemical markers has been shown in study which can significantly contribute in diagnosing early event in process of malignant transformation of suspicious OSF cases so that better treatment plan could be formulated for better prognosis. More efforts should be emphasized on combination of \antibodies and its importance in target drug therapy
Leiomyosarcoma of mandible: A case report and review of literature
No full textOne challenging feature of head and neck pathology is that a dizzying array of spindle cell lesions occurs here which ranges all the way from reactive, malignant to very aggressive forms. The aim of this article is to describe a rare case of leiomyosarcoma (LMS) of the mandible with immunohistochemical analysis that was useful in making the final diagnosis.A 65-year-old woman was referred to our institute for evaluation of a swelling on the right side of the facial region. This lesion presented a fast growth in the last 6 months. Intraoral examination showed a firm, fixed, red colored mass with no lymph nodes involvement. The radiographic examination showed a multiple radio-opaque nodules in right mandibular region with pathological fracture. Microscopic examination of the mandibular lesion showed spindle cells exhibiting moderately enlarged and pleomorphic nuclei with coarse, unevenly dispersed chromatin. Neoplastic cells expressed strong immunopositivity for Muscle- Specific Actin, Smooth muscle actin and are negative for Desmin and S-100 protein. Ki-67 proliferation index is <1%. These findings were consistent with the diagnosis of leiomyosarcoma
