1,966 research outputs found
Modulation of Gene Expression of Rabbit Chondrocytes by Dynamic Compression in Polyurethane Scaffolds with Collagen Gel Encapsulation
No full textMolecular dynamics simulations to investigate the relationship between the structural stability and amyloidogenesis of the wild-type and N-terminal hexapeptide deletion Delta N6 beta 2-microglobulin
No full textQuantitative analysis of osteoblast-like cells (MG63) morphology on nanogrooved substrata with various groove and ridge dimensions
No full textMolecular Dynamics Simulations to Investigate the Aggregation Behaviors of the A beta(17-42) Oligomers
No full textGluon fusion and bb¯ corrections to HW+W−/HZZ production in the POWHEG-BOX
No full textAbstractThe study of the Higgs boson properties is one of the most important tasks to be accomplished in the next years, at the Large Hadron Collider (LHC) and at future colliders such as the Future Circular Collider in hadron–hadron mode (FCC-hh), the potential 100 TeV follow-up of the LHC machine. In this view the precise study of the Higgs couplings to weak gauge bosons is crucial and requires as much information as possible. After the recent calculation of the next-to-leading order QCD corrections to the production cross sections and differential distributions of a Standard Model Higgs boson in association with a pair of weak bosons, matched with parton shower in the POWHEG-BOX framework, we present the gluon fusion correction gg→HW+W−(HZZ) to the process pp→HW+W−(HZZ). This correction can be sizeable and amounts to +3% (+10%) in the HW+W− process and +5% (+18%) in the HZZ process at the LHC (FCC-hh). We also present the first study of the impact of the bottom-quark initiated channels bb¯→HW+W−/HZZ and find that they induce a significant +18% correction in the HW+W− channel at the FCC-hh. We present results on total cross sections and distributions at the LHC and at the FCC-hh
Dynamic comparison of children's adaptability to elementary school: Fourteen years later
No full textChondrogenesis from immortalized human mesenchymal stem cells: Comparison between collagen gel and pellet culture methods
No full textAssociation of polyethylene friction and thermal unfolding of interfacial albumin molecules
No full textKrakenOnMem: A Memristor-Augmented HW/SW Framework for Taxonomic Profiling
No full textState-of-the-art taxonomic profilers that comprise the first step in larger-context metagenomic studies have proven to be computationally intensive, i.e., while accurate, they come at the cost of high latency and energy consumption. Table Lookup operation is a primary bottleneck of today's profilers. In this paper, we first propose TL-PIM, a hardware accelerator based on the processing-in-memory (PIM) paradigm to accelerate Table Lookup. TL-PIM leverages the in-memory compute capability of emerging memory technologies along with intelligent data mapping. Then, we integrate TL-PIM into Kraken2, a state-of-the-art metagenomic profiler, and build an HW/SW co-designed profiler, called KrakenOnMem. Results from a silicon-based prototype of our emerging memory validate the design and required operations on a smaller scale. Our large-scale calibrated simulations show that KrakenOnMem can provide an average of 61.3% speedup compared to original Kraken2 for end-to-end profiling. Additionally, our design improves the energy consumption by orders of magnitude compared to the original Kraken2 while incurring a negligible area overhead. Computer EngineeringElectrical Engineering, Mathematics and Computer ScienceQuantum & Computer Engineerin
The Insulator Protein SU(HW) Fine-Tunes Nuclear Lamina Interactions of the Drosophila Genome
No full textSpecific interactions of the genome with the nuclear lamina (NL) are thought to assist chromosome folding inside the nucleus and to contribute to the regulation of gene expression. High-resolution mapping has recently identified hundreds of large, sharply defined lamina-associated domains (LADs) in the human genome, and suggested that the insulator protein CTCF may help to demarcate these domains. Here, we report the detailed structure of LADs in Drosophila cells, and investigate the putative roles of five insulator proteins in LAD organization. We found that the Drosophila genome is also organized in discrete LADs, which are about five times smaller than human LADs but contain on average a similar number of genes. Systematic comparison to new and published insulator binding maps shows that only SU(HW) binds preferentially at LAD borders and at specific positions inside LADs, while GAF, CTCF, BEAF-32 and DWG are mostly absent from these regions. By knockdown and overexpression studies we demonstrate that SU(HW) weakens genome – NL interactions through a local antagonistic effect, but we did not obtain evidence that it is essential for border formation. Our results provide insights into the evolution of LAD organization and identify SU(HW) as a fine-tuner of genome – NL interactions.BiotechnologyApplied Science
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