3,681 research outputs found
Supporting data for "3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments"
No full textA full description of the data set is included in the file "Readme_Meng_Tumor_Model.txt".The data set includes the experimental data and the corresponding code files for " 3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments", Fanben Meng, Carolyn M Meyer, Daeha Joung, Daniel A Vallera, Michael C McAlpine, Angela Panoskaltsis‐Mortari, Adv. Mater. 2019, 31 (10), 1806899. The development of 3D in vitro models capable of recapitulating native tumor microenvironments could improve the translatability of potential anticancer drugs and treatments. Here, 3D bioprinting techniques are used to build tumor constructs via precise placement of living cells, functional biomaterials, and programmable release capsules. This enables the spatiotemporal control of signaling molecular gradients, thereby dynamically modulating cellular behaviors at a local level. Vascularized tumor models are created to mimic key steps of cancer dissemination (invasion, intravasation, and angiogenesis), based on guided migration of tumor cells and endothelial cells in the context of stromal cells and growth factors. The utility of the metastatic models for drug screening is demonstrated by evaluating the anticancer efficacy of immunotoxins. These 3D vascularized tumor tissues provide a proof-of-concept platform to i) fundamentally explore the molecular mechanisms of tumor progression and metastasis, and ii) preclinically identify therapeutic agents and screen anticancer drugs.National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Award No. 1R21EB022830)A seed grant from the UMN Institute for Engineering in MedicineA Pilot Project award from the UMN Prostate and Urologic Cancer Translational WorkgroupNational Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health (Award No. 1DP2EB020537)Cancer Bioengineering Fellowship, UMN Physical Sciences in Oncology Center (PSOC)Meng, Fanben; Meyer, Carolyn M; Joung, Daeha; Vallera, Daniel A; McAlpine, Michael C; Panoskaltsis-Mortari, Angela. (2020). Supporting data for "3D Bioprinted In Vitro Metastatic Models via Reconstruction of Tumor Microenvironments". Retrieved from the University Digital Conservancy, https://doi.org/10.13020/xxnh-v194
Supporting data for "3D Printed Polymer Photodetectors"
No full textThis data set includes the supporting data for 3D printed polymer photodetectors.Extrusion-based 3D printing, an emerging technology, has been previously used in the comprehensive fabrication of light-emitting diodes using various functional inks, without cleanrooms or conventional microfabrication techniques. Here, polymer-based photodetectors exhibiting high performance are fully 3D printed and thoroughly characterized. A semiconducting polymer ink is printed and optimized for the active layer of the photodetector, achieving an external quantum efficiency of 25.3%, which is comparable to that of microfabricated counterparts and yet created solely via a one-pot custom built 3D-printing tool housed under ambient conditions. The devices are integrated into image sensing arrays with high sensitivity and wide field of view, by 3D printing interconnected photodetectors directly on flexible substrates and hemispherical surfaces. This approach is further extended to create integrated multifunctional devices consisting of optically coupled photodetectors and light-emitting diodes, demonstrating for the first time the multifunctional integration of multiple semiconducting device types which are fully 3D printed on a single platform. The 3D-printed optoelectronic devices are made without conventional microfabrication facilities, allowing for flexibility in the design and manufacturing of next-generation wearable and
3D-structured optoelectronics, and validating the potential of 3D printing to achieve high-performance integrated active electronic materials and devices.National Institute of Biomedical Imaging and Bioengineering of the National Institutes of Health, Award number: 1DP2EB020537Boeing CompanyThe State of Minnesota MnDRIVEPark, Sung Hyun; Su, Ruitao; Guo, Shuang-Zhuang; Qiu, Kaiyan; Joung, Daeha; Fanben, Meng; McAlpine, Michael C; Jeong, Jaewoo. (2020). Supporting data for "3D Printed Polymer Photodetectors". Retrieved from the University Digital Conservancy, https://doi.org/10.13020/z6np-q485
Supporting data for "3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors"
No full textFull description in the file "QiuReadme.txt".The data set includes the experimental data and the corresponding MRI stereolithography (STL) file supporting the results reported in Kaiyan Qiu; Zichen Zhao; Ghazaleh Haghiashtiani; Shuang-Zhuang Guo; Mingyu He; Ruitao Su; Zhijie Zhu; Didarul B. Bhuiyan; Paari Murugan; Fanben Meng; Sung Hyun Park; Chih-Chang Chu; Brenda M. Ogle; Daniel A. Saltzman; Badrinath R. Konety; Robert M. Sweet; Michael C. McAlpine. 3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors. Adv. Mater. Technol. 2018, 3, 1700235. The design and development of novel methodologies and customized materials to fabricate patient-specific 3D printed organ models with integrated sensing capabilities could yield advances in smart surgical aids for preoperative planning and rehearsal. Here, we demonstrate 3D printed prostate models with physical properties of tissue and integrated soft electronic sensors using custom-formulated polymeric inks. The models show high quantitative fidelity in static and dynamic mechanical properties, optical characteristics, and anatomical geometries to patient tissues and organs. The models offer tissue-like tactile sensation and behavior and thus can be used for the prediction of organ physical behavior under deformation. The prediction results show good agreement with values obtained from simulations. The models also allow the application of surgical and diagnostic tools to their surface and inner channels. Finally, via the conformal integration of 3D printed soft electronic sensors, pressure applied to the models with surgical tools can be quantitatively measured.National Institutes of Health, Grant 1DP2EB020537National Institutes of Health, Grant R01HL137204Army Research Office, Grant W911NF-15-1-0469Department of Urology, University of MinnesotaRebecca Q. Morgan FoundationQiu, Kaiyan; Zhao, Zichen; Haghiashtiani, Ghazaleh; Guo, Shuang-Zhuang; He, Mingyu; Su, Ruitao; Zhu, Zhijie; Bhuiyan, Didarul B; Murugan, Paari; Meng, Fanben; Park, Sung Hyun; Chu, Chih-Chang; Ogle, Brenda M; Saltzman, Daniel A; Konety, Badrinath R; Sweet, Robert M; McAlpine, Michael C. (2020). Supporting data for "3D Printed Organ Models with Physical Properties of Tissue and Integrated Sensors". Retrieved from the University Digital Conservancy, https://doi.org/10.13020/rbvt-5s33
Migrant workers, collaborative research and spatial pressures : an interview with Meng Yue
No full textIn July last year I had the opportunity to interview Meng Yue, literary scholar and author of Shanghai and the Edges of Empire (2006). Meng Yue has been collaborating with Toronto-based architect and artist Adrian Blackwell for a number of years, with their students from literature and architecture undertaking highly interesting research on the peripheral zones of Beijing. Questions of peri-urban food production, land use, resource distribution and the multiplication of labour skills have framed these investigations. The interview below is extracted from a considerably longer discussion we had in Beijing during the late summer of 2007, half of which was lost to the faulty battery of an ipod (the rest remains to be transcribed from video…)
Correction to: Visible lattice points along curves
No full textThe article “Visible lattice points along curves”, written by Kui Liu and Xianchang Meng, was originally published electronically on the publisher’s internet portal on 27 July 2020 without open access. With the author(s)’ decision to opt for Open Choice the copyright of the article changed on 9 July 2021 to © The Author(s) 2020 and the article is forthwith distributed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0
Sequels to honglou meng : how gu taiqing continues the story in honglou meng ying
No full textAfter Honglou meng (1791) was published, a number of sequels appeared that redefined its major characters, rewrote its ending, and continued the story of life within the two Jia households. One of these was Honglou meng ying (1877), by female poet, Gu Taiqing. Despite its status as the earliest extant novel written by a woman, few studies have been devoted to examining it. Building on research that Ellen Widmer has provided on Gu Taiqing and her work, including Honglou meng ying, I will explore the novel further in terms of its relationship to the parent work and to other sequels written by men, and also examine it on its own terms as a literary work. Some of the main questions that I will address include: how does it compare to other sequels to Honglou meng? How does Gu Taiqing’s continuation of Honglou meng depart from the parent novel? I have organized my discussion by providing an introduction to Gu Taiqing, whilst providing contextual information about women’s education, their relationship to fiction, and the impact of Honglou meng. Chapter One will deal with the broad issue of sequels in the Chinese context, the popularity of writing sequels during the Ming and Qing dynasties, and conclude with some observations about Honglou meng sequels in particular. The second chapter will deal exclusively with Gu Taiqing’s Honglou meng ying, evaluating it in terms of how the author continues the parent work, how she refashions its characters and themes, and how her sequel reflects her own unique concerns (which may not have been part of the original parent work). Finally, I will conclude with some remarks about Honglou meng ying in terms of its relation to sequel writing in late imperial China and its contribution to our understanding of women’s reading and writing in the final years of the Qing dynasty.Arts, Faculty ofAsian Studies, Department ofGraduat
On Meng Sen's teaching and lecture notes of Ming and Qing history at Peking University during the 1930s
No full textWhile teaching the histories of the Ming and Qing dynasties, Meng Sen (1869-1937), developed three textbooks in the 1930s: Lecture Notes on the Ming History (.... Mingshi jiangyi), Lecture Notes on the Qing History (.... Qingshi jiangyi), and Lecture Notes on the History of the Founding of the Manchu State (....... Manzhou kaiguo shi jiangyi). In these book titles, the term " history" refers specifically to "standard history."In tracing Meng Sen's original intention in producing these textbooks, all three works suggest the author's desire to write history. He wrote Lecture Notes on the Ming History to prepare a future revision of the History of the Ming (.. Mingshi); similarly he wrote Lecture Notes on the Qing History and Lecture Notes on the History of the Founding of the Manchu State with the intention to revise the Draft History of the Qing (... Qingshi gao). Meng Sen summarized Sima Guang's (..., 1019-86) view of history as " imitating the good and avoiding the bad," which he believed represented the "essential meaning of history." Meng followed Sima Guang's model in compiling the Lecture Notes on the Ming History and Lecture Notes on the Qing History, as shown in their style and format. By comparison, his writing of the Lecture Notes on the History of the Founding of the Manchu State attempted to merge the traditional annals-biographic style with narrative history from the West, or to pour old wine into a new bottle. Meng Sen presented his innovative efforts at Peking University, introducing young scholars to standards for history writing, and doing his utmost to guide and encourage his students; some of whom became noted scholars in the study of Ming and Qing histories.A&HCIARTICLE2119-1545
Regarding the Dates of Birth and Death of Li Meng-Yang : Ming Period Poet
No full textIn this paper, the author has confirmed the dates of birth and death of Li
Meng-Yang, a poet of middle period of the Ming dynasty in China.
The author has referred his poems and literature as well as letters written
between him and his friends, and critically reviewed various views and arguments
about his lifetime compiled over the past four hundred years.
In conclusion, the author has determined the date of his birth and death as
follows according to lunar calendar. Li Meng-Yang was born on the 7th of
December, Cheng-Hua 8 (1472), and died 30th of December, Jia-Jing 8 (1529).departmental bulletin pape
Characteristics of the Cervical Microbiome in Women with Cervical Insufficiency (CI) and its Role in Predicting the Successful Cerclage / Pessary Intervention
No full textMeng, Meng.Thesis Ph.D. Chinese University of Hong Kong 2016.Includes bibliographical references (leaves ).Abstracts also in Chinese.Title from PDF title page (viewed on …)
Functional molecular transport junctions based on nanogap structures
No full textThe use of individual molecules as functional components in electronic circuits offers the great opportunity to improve and revolutionize electronic systems. With the rapid achievement of nanofabrication, molecular electronic devices have been realized based on the investigation of electron properties of molecules. However, the study to build molecular architectures with electronic functions still leaves us a lot of room for improvement and optimization. Hence, this dissertation focuses on the exploration of hybridized electronic systems with judiciously designed molecules and metal nanostructures, to undertake advanced and complex functions.
Herein, the newly-developed on-wire lithography (OWL) is employed to fabricate nanogaps as nanoelectrode pairs for the formation of molecular transport junctions (MTJs), the most essential structures in molecular electronics. In order to obtain more complex nanodevices with advanced functions, rationally designed or selected molecules are utilized to functionalize the nanogap structure, while several external stimulations are also introduced to modulate the device performance.
Firstly, photo-modulable MTJs are developed via OWL-generated nanogaps functionalized by rationally designed and synthesized complexes with the photochromic dithienylethene unit(s) bearing the electro-active ruthenium fragments. A reversible and repeatable bi-state conductive switching upon alternate irradiation of UV and visible light is distinctly observed. Then, more external stimulations are introduced and orthogonally modulated MTJs are further achieved. The addressable and stepwise control of molecular isomerization is repeatedly and reversibly completed with a judicious use of the orthogonal optical and electrochemical. Through the rational design, these photo-/electro-cooperative nanodevices can be applied as resettable electronic logic gates for Boolean computing.
Besides chemically synthesized organometallic complexes, natural biomolecules are also used to functionalize nanogap structures. A programmable controllable and reproducible memristive behavior is achieved by natural ferritin-based MTJs, which can be applied for nonvolatile memory. Additionally, the rapid development of biotechnology provides us another option to improve the device function or performance. By tuning the amount of iron inside an engineered ferritin, the ON/OFF ratio of conductance switching of such protein-based nanodevices is modulated accordingly, suggesting that protein molecules can be tailored using biotechnology to suit the specific requirements of molecular devices. These works provide direct proof that natural biomolecules as a parallel choice of chemically synthesized complex can be used to fabricate functional nanodevices.
In conclusion, we develop advanced molecular nanodevices based on the feasible platform of precise nanogap structures fabricated by OWL, under various external controls. Both the synthetic chemistry and natural biosystem have been demonstrated to present enormous resources that fulfill the requirement of molecular devices. With chemical or biological modification of molecular architectures, the function and performance can be obviously improved. Therefore, after optimizing fabrication and operative conditions, such functional MTJs show promising applications in multifunctional nanocircuits.DOCTOR OF PHILOSOPHY (MSE
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