793 research outputs found
Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant
No full textBakalářská práce na téma Statistické měření přesnosti dodávek výrobků od ZF Aftermarket Frýdlant je zaměřena na aplikaci statistických metod, díky kterým je možné získat potřebné informace o tom, jak si pobočka ZF Aftermarket Frýdlant stojí v roli dodavatele.V teoretické části bakalářské práce jsou uvedeny poznatky týkající se dodavatelsko-odběratelských vztahů, logistiky a statistických analýz. V praktické části je popsána práce s vnitřními systémy společnosti ZF Aftermarket Frýdlant a dále s předplacenými programy od společnosti Microsoft jako jsou MS Word, MS Excel a MS Access. Tyto programy napomáhají vytvoření databáze, která bude sloužit jako týdenní report pro Supply Chain Managera a vedení společnosti pobočky ZF Aftermarket Frýdlant.Cílem práce je vytvoření sebereflexního zhodnocení pobočky ZF Aftermarket Frýdlant v roli dodavatele.The bachelor thesis Measuring accuracy of delivery quantities from ZF Aftermarket Frydlant is focused on the application of statistical methods, which enables us to obtain the necessary information on how the ZF Aftermarket Frýdlant branch proves itself to be a supplier.The theoretical part of the bachelor thesis presents current knowledge of supplier-buyer relationships, logistics and statistical analyses. In the practical part of this work, the author works with ZF Aftermarket Frýdlant internal systems, as well as prepaid Microsoft applications such as MS Word, MS Excel and MS Access. These applications help to create the database which would be used as a weekly report for the RMG Manager and the management of the branch ZF Aftermarket Frýdlant. The main aim of this thesis is to create a self-reflective evaluation of the branch ZF Aftermarket Frýdlant as a supplier
Next-Generation Sequencing: Application in Liver Cancer—Past, Present and Future?
No full textHepatocellular Carcinoma (HCC) is the third most deadly malignancy worldwide characterized by phenotypic and molecular heterogeneity. In the past two decades, advances in genomic analyses have formed a comprehensive understanding of different underlying pathobiological layers resulting in hepatocarcinogenesis. More recently, improvements of sophisticated next-generation sequencing (NGS) technologies have enabled complete and cost-efficient analyses of cancer genomes at a single nucleotide resolution and advanced into valuable tools in translational medicine. Although the use of NGS in human liver cancer is still in its infancy, great promise rests in the systematic integration of different molecular analyses obtained by these methodologies, i.e., genomics, transcriptomics and epigenomics. This strategy is likely to be helpful in identifying relevant and recurrent pathophysiological hallmarks thereby elucidating our limited understanding of liver cancer. Beside tumor heterogeneity, progress in translational oncology is challenged by the amount of biological information and considerable “noise” in the data obtained from different NGS platforms. Nevertheless, the following review aims to provide an overview of the current status of next-generation approaches in liver cancer, and outline the prospects of these technologies in diagnosis, patient classification, and prediction of outcome. Further, the potential of NGS to identify novel applications for concept clinical trials and to accelerate the development of new cancer therapies will be summarized
Deformation and fracture behaviors of Co-based metallic glass and its composite with dendrites
No full textHalf-ZF beamforming scheme for downlink two-user multiple input single output-based non-orthogonal multiple access systems
No full textThe authors investigate the beamforming (BF) problem to minimise the power consumption for the downlink 2-user multiple input single output-based non-orthogonal multiple access system. Inspired from the conventional zero-forcing (ZF) scheme, they propose the Half-ZF scheme which only mitigates the interference introduced by the signal of the cell-interior user through the ZF method. Meanwhile, the interference introduced by the signal of the cell-edge user is removed through the SIC technology. We derive the closed-form expression for the BF vectors of the two users under the Half-ZF scheme. The optimal power consumption for the Half-ZF scheme is analysed and the corresponding solution of the BF factors are also obtained. Compared with the conventional ZF scheme, both the Half-ZF scheme and the existing quasi-degradation (QD) scheme can achieve lower power consumption than the ZF scheme. However, the Half-ZF scheme can achieve this advantage under more relaxed conditions. Consequently, the Half-ZF scheme consumes lower power than the QD scheme when combined with the ZF scheme in practical systems.SCI(E)ARTICLE101633-16401
One-hybrid system for detection of ZF–DNA interactions () Schematic of genetic selection system for interrogating ZF–DNA interactions
No full text<p><b>Copyright information:</b></p><p>Taken from "Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells"</p><p>Nucleic Acids Research 2005;33(18):5978-5990.</p><p>Published online 26 Oct 2005</p><p>PMCID:PMC1270952.</p><p>© The Author 2005. Published by Oxford University Press. All rights reserved</p> () Plasmids for one-hybrid genetic selection system. The reporter gene, either chloramphenicol acetyltransferase (CAT), or GFP is located downstream from a weak derivative promoter (P) on pDB series plasmids. A 9 bp target site for binding by the ZF is located at a specific distance from the start of transcription. On the pA series of plasmids, the gene for the ZF is fused to a fragment of the α-subunit of RNA polymerase ([]) via a sequence coding for an amino acid linker. Binding of the RpoA[1–248]–ZF fusion to the 9 bp site in the reporter plasmid recruits the other RNA polymerase subunits to stimulate transcription of the reporter gene
Research on Transmission Characteristic of ZF 9-speed Automatic Transmission
No full textTaking the ZF 9-speed automatic transmission (9HP48) as the research object，the power transmission line in each gear of the automatic transmission is clarified. The transmission ratio and torque ratio (considering friction loss) of each gear are theoretically derived. The М.А.Крейнeс formula is used to calculate the transmission efficiency of 9 forward gears and 1 reverse gear. To verify the theoretical derivation，AMESim simulation software is used for building the simulation model of the automatic transmission. The transmission ratio and transmission efficiency values of each gear are obtained through the simulation calculation. The simulation results are consistent with the theoretical analysis results. The simulation results verify the correctness of the theoretical derivation and provide a basis for optimizing the automatic transmission scheme in the future
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Enhanced 2,3-butanediol production from gluconate anaerobically by metabolically engineered Klebsiella oxytoca DSM 4798
No full textThis study aims to explore the use of gluconate as an alternative substrate for 2,3-butanediol (2,3-BD) production from an engineered Klebsiella oxytoca DSM 4798. Historically, glucose has been the primary substrate for microbial 2,3-BD production. However, its fermentation necessitates microaerobic conditions due to inherent redox imbalances. This study reveals that the conversion of gluconate to 2,3-BD is redox balanced, allowing for a streamlined anaerobic fermentation process, which is industrially advantageous and circumvents the late-stage 2,3-BD consumption observed in glucose microaerobic fermentation. The K. oxytoca DSM 4798 strain achieved a 2,3-BD yield of 47% and 54% from gluconate and glucose, respectively. The genetically modified MJ09 (∆ldhA ∆ackA-pta ∆frdABCD ∆adhE) strain demonstrated a significant enhancement, achieving a 2,3-BD yield of 90% from gluconate while maintaining redox balance. Meanwhile, there was no achievable growth shown for the MJ09 strain when glucose was the carbon source. This is attributed to the redox balance achieved when 2,3-BD is anaerobically produced from gluconate and it is not balanced when glucose is the carbon source. Gluconate can serve as an advantageous alternative carbon source in the production of 2,3-BD in anaerobic fermentation of K. oxytoca
On the consistency of ZF with an elementary embedding from into
No full textAccording to a theorem due to Kenneth Kunen, under ZFC, there is no ordinal
and non-trivial elementary embedding . His proof relied on the Axiom of Choice (AC), and no proof from
ZF alone has been discovered.
is the assertion, introduced by W. Hugh Woodin, that
is an ordinal and there is an elementary embedding
with critical point . And
asserts that holds for some . The axiom is
one of the strongest large cardinals not known to be inconsistent with AC. It
is usually studied assuming ZFC in the full universe (in which case
must be a limit ordinal), but we assume only ZF.
We prove, assuming ZF + + " is an even ordinal",
that there is a proper class transitive inner model containing
and satisfying ZF + + "there is an elementary
embedding "; in fact we will have , where witnesses in . This result was first proved by
the author under the added assumption that exists; Gabe
Goldberg noticed that this extra assumption was unnecessary. If also
is a limit ordinal and -DC holds in , then the model will also
satisfy -DC.
We show that ZFC + " is even" + implies
exists for every , but if consistent, this theory does not
imply exists.Comment: 44 pages. Final author accepted version. For published version see
https://doi.org/10.1142/S0219061324500132. Changes this version: reorganized
order of presentation of some material (but no really new sections are
present). Slightly generalized results by dealing with relevant triples (see
Def 2.5, Theorem 4.2, etc). Various minor corrections and modification
Content caching and delivery in wireless radio access networks
No full textToday's mobile data traffic is dominated by content-oriented traffic. Caching popular contents at the network edge can alleviate network congestion and reduce content delivery latency. This paper provides a comprehensive and unified study of caching and delivery techniques in wireless radio access networks (RANs) with caches at all edge nodes (ENs) and user equipments (UEs). Three cache-aided RAN architectures are considered: RANs without fronthaul, with dedicated fronthaul, and with wireless fronthaul. It first reviews in a tutorial nature how caching facilitates interference management in these networks by enabling interference cancelation (IC), zero-forcing (ZF), and interference alignment (IA). Then, two new delivery schemes are presented. One is for RANs with dedicated fronthaul, which considers centralized cache placement at the ENs but both centralized and decentralized placement at the UEs. This scheme combines IA, ZF, and IC together with soft-transfer fronthauling. The other is for RANs with wireless fronthaul, which considers decentralized cache placement at all nodes. It leverages the broadcast nature of wireless fronthaul to fetch not only uncached but also cached contents to boost transmission cooperation among the ENs. The numerical results show that both schemes outperform existing results for a wide range of system parameters, thanks to the various caching gains obtained opportunistically
Health Care Clinical Preceptors’ Attitudes Towards Interprofessional Education in Saudi Arabia: A Cross-Sectional Study [Corrigendum]
No full textAl Nufaiei ZF, Bukhari AA, Abalkhail NA, et al. Adv Med Educ Pract. 2024;15:343–355.
The authors have advised there is an error in the author list on page 343. The author name “Fahad Allhadian” should read “Fahad Alhadian”.
The authors apologize for this error
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