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Influence of diluent alkyl substitution on the extraction of Am(III) and Eu(III) by a 6,6’-bis(1,2,4-triazin-3-yl)-2,2’-bipyridine ligand dissolved in alkylated cyclohexanone Diluents
Get PDFSeveral alkylated cyclohexanones were investigated as potential diluents for the selective extraction of Am(III) from Eu(III) from nitric acid solutions by the CyMe4-BTBP ligand. No significant extraction of either of the metal ions was observed for these diluents themselves. In the extractions from 1 M HNO3, 3-methylcyclohexanone and 4-methylcyclohexanone gave comparable results to cyclohexanone whereas in the extractions from 4 M HNO3, 2-methylcyclohexanone, 3-methylcyclohexanone and 4-methylcyclohexanone all gave superior results. For the monomethylated diluents, DAm and SFAm/Eu decreased in the order of alkyl substitution 2 > 4 ~ 3. However, alkyl substitution of cyclohexanone significantly slows down the extraction kinetics compared to cyclohexanone, and the position of alkyl substitution was found to play an important role in the solvents properties. 3-Methylcyclohexanone was identified as the most promising of the diluent
Sıcak Bölgelerdeki Seralarda Fan-Ped Sisteminin Etkinliğinin Belirlenmesi
No full textBu çalışmada, Antalya ilinde sıcaklığın yüksek olduğu Temmuz, Ağustos ve Eylül aylarında fan-ped sisteminin etkinliği belirlemek amacıyla iç ve dış sıcaklık değerleri incelenmiştir. Antalya yöresindeki serinletme sistemi olmayan seralarda iç sıcaklık değerleri rahatlıkla 40 oC’nin üzerine çıkabilmektedir. Antalya ilinde sıcaklığın yüksek olduğu Temmuz ve Ağustos aylarında, optimum üretim yapılabilmesi için sera içi uygun iklim koşullarının sağlanması gerekir. Bu amaçla sıcaklık ve nem ile ilgili ölçümler yapılmıştır. Bu bilgiler doğrultusunda elde edilen veriler ile önerilen değerler kıyaslanarak sera içi iklim parametrelerinden biri olan sıcaklığın, ne ölçüde ve neden değiştiği belirlenmeye çalışılmıştır.
Yaz mevsiminde araştırmaya konu olan serada aşırı sıcaklık artışını önlemek için serinletme uygulaması yapılmıştır. Serada doğal havalandırmayla ulaşılabilen değerlerden daha düşük iç ortam sıcaklığı istenildiğinden, seraya giren hava sıcaklığını azaltmak ve oransal nem değerini artırarak bitki su stresini önlemek için, nemlendirmeli serinletme sistemi kullanıldı. Özellikle Antalya gibi sıcak iklim bölgelerinde fan-ped sistemi ile iç ortam sıcaklığı 7 ile 14 oC‘ye kadar soğutulabileceği belirlenmiştir
The effects of relativistic corrections on cosmological parameter estimations from Sunyaev-Zeldovich effect cluster surveys
No full textSunyaev-Zeldovich effect (SZE) cluster surveys are anticipated to yield tight constraints on cosmological parameters, such as the equation of state of dark energy. In this paper, we study the effect of relativistic corrections of the thermal SZE on the cluster number counts expected from a cosmological model and thus, assuming that other cosmological parameters are known to high accuracies, on the determination of the w-parameter and sigma(8) from an SZE cluster survey, where w = p/rho (with p the pressure and rho the density of dark energy) and sigma(8) is the rms of the extrapolated linear density fluctuation smoothed over 8 Mpc h(-1). For the purpose of illustrating the effects of relativistic corrections, our analyses mainly focus on nu = 353 GHz and S-lim = 30 mJy, where nu and S-lim are the observing frequency and the flux limit of a survey, respectively. These observing parameters are relevant to the Planck survey. It is found that from two measurable quantities, the total number of SZE clusters and the number of clusters with redshift z greater than or equal to 0: 5, sigma(8) and w can be determined to a level of +/-1% and +/-8%, respectively, with 1 sigma uncertainties from a survey of 10,000 deg(2). Relativistic effects are important in determining the central values of sigma(8) and w. If we choose the two quantities calculated relativistically from the flat cosmological model with sigma(8) = 0.8284 and w = -0.75 as input, the derived sigma(8) and w would be 0.819 and -0.81, respectively, if relativistic effects are wrongly neglected. The location of the resulting sigma(8) and w in the sigma(8)-w plane is outside the 3 sigma region around the real central sigma(8) and w.Astronomy & AstrophysicsSCI(E)0ARTICLE2713-71959
Doctor-family-patient relationship: The Chinese paradigm of informed consent
No full textBioethics is a subject far removed from the Chinese, even from many Chinese medical students and medical professionals. In-depth interviews with eighteen physicians, patients, and family members provided a deeper understanding of bioethical practices in contemporary China, especially with regard to the doctor-patient relationship (DPR) and informed consent. The Chinese model of doctor-family-patient relationship (DFPR), instead of DPR, is taken to reflect Chinese Confucian cultural commitments. An examination of the history of Chinese culture and the profession of medicine in China is used to disclose the deep roots of these commitments. The author predicts that the DFPR model will further develop in China but that it will maintain its Chinese character.EthicsSocial Sciences, BiomedicalPubMedCPCI-SSH(ISSHP)SSCI4
Optimization of 3‑Pyrimidin-4-yl-oxazolidin-2-ones as Allosteric and Mutant Specific Inhibitors of IDH1
No full textHigh throughput screening and subsequent
hit validation identified 4-isopropyl-3-(2-((1-phenylethyl)amino)pyrimidin-4-yl)oxazolidin-2-one
as a potent inhibitor of IDH1R132H. Synthesis of the four
separate stereoisomers identified the (S,S)-diastereomer (IDH125, 1f) as
the most potent isomer. This also showed reasonable cellular activity
and excellent selectivity vs IDH1wt. Initial structure–activity
relationship exploration identified the key tolerances and potential
for optimization. X-ray crystallography identified a functionally
relevant allosteric binding site amenable to inhibitors, which can
penetrate the blood–brain barrier, and aided rational optimization.
Potency improvement and modulation of the physicochemical properties
identified (S,S)-oxazolidinone IDH889 (5x) with good exposure and 2-HG inhibitory
activity in a mutant IDH1 xenograft mouse model
MONTE-CARLO STUDY OF 3-D Z4 GAUGE-Z2 HIGGS THEORY WITH RADIAL DEGREE OF FREEDOM
No full textPhysics, MultidisciplinarySCI(E)中国科学引文数据库(CSCD)0ARTICLE3311-3251
CHINESE PATENT-LAW AND PATENT INFORMATION-SERVICE
No full textInformation Science & Library ScienceSSCI1ARTICLE111-182
Comments on author citations for nomenclatural novelties published in volume 15 of the Flora Reipublicae Popularis Sinicae (FRPS)
No full textSpin-Crossover in Supramolecular Iron(II)-2,6-bis(1 H-Pyrazol-1-yl)pyridine Complexes: Toward Spin-State Switchable Single-Molecule Junctions
Get PDFSpin-crossover (SCO) active iron(II) complexes are an integral class of switchable and bistable molecular materials. Spin-state switching properties of the SCO complexes have been studied in the bulk and single-molecule levels to progress toward fabricating molecule-based switching and memory elements. Supramolecular SCO complexes featuring anchoring groups for metallic electrodes, for example, gold (Au), are ideal candidates to study spin-state switching at the single-molecule level. In this study, we report on the spin-state switching characteristics of supramolecular iron(II) complexes 1 and 2 composed of functional 4-([2,2′-bithiophen]-5-ylethynyl)-2,6-di(1H-pyrazol-1-yl)pyridine (L1) and 4-(2-(5-(5-hexylthiophen-2-yl)thiophen-2-yl)ethynyl)-2,6-di(1H-pyrazol-1-yl)pyridine (L2) ligands, respectively. Density functional theory (DFT) studies revealed stretching-induced spin-state switching in a molecular junction composed of complex 1, taken as a representative example, and gold electrodes. Single-molecule conductance traces revealed the unfavorable orientation of the complexes in the junctions to demonstrate the spin-state dependence of the conductance.QN/van der Zant La
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