1,458 research outputs found
A comparison of five different bone resorption markers in osteosarcoma‐bearing dogs, normal dogs, and dogs with orthopedic diseases
No full textBackground: Various bone resorption markers in humans are useful for supporting the diagnosis of malignant skeletal
pathology, with certain bone resorption markers appearing to be more discriminatory for detecting cancer-induced osteolysis
than others. Canine osteosarcoma (OSA) is characterized by focal bone destruction, but a systematic investigation for determining which bone resorption marker best supports the diagnosis of OSA in dogs has not been reported.
Hypothesis: Dogs with OSA will have increased concentrations of bone resorption markers compared with healthy dogs
and dogs with orthopedic disorders. Differences will exist among various bone resorption markers for their ability to support
the diagnosis of malignant osteolysis in dogs with OSA.
Animals: Single time point, cross-sectional, cohort study including dogs with OSA (n 5 20) or orthopedic disorders (n 5 20)
and healthy dogs (n 5 22).
Methods: Basal concentrations of urine and serum N-telopeptide (NTx), urine and serum C-telopeptide (CTx), and urine
deoxypyridinoline (DPD) were compared among all 3 groups.
Results: Compared with healthy dogs and dogs with orthopedic disorders, urine NTx, serum NTx, and serum CTx concentrations were significantly increased in dogs with OSA. For urine NTx and serum NTx, the calculated lower and upper 95%
confidence limits in dogs with OSA did not overlap with dogs diagnosed with orthopedic disorders or healthy dogs.
Conclusions and clinical importance: Of the markers evaluated in this study, urine NTx and serum NTx appear to be the
most discriminatory resorption markers supporting the diagnosis of focal malignant osteolysis in dogs with OSA.
Key words: Bone pain; Canine cancer; Circulating surrogate markers; Focal malignant osteolysis
Author Correction:A cattle graph genome incorporating global breed diversity
No full textThe original version of this Article omitted from the author list the 12th and 13th authors Dennis Muhanguzi and Wilson Amanyire, who are from the ‘School of Biosecurity, Biotechnology and Laboratory Sciences (SBLS), College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, P.O Box 7062, Kampala, Uganda’. Consequently, the final sentence of the Author Contributions incorrectly read ‘D.W., P.T., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been replaced with ‘D.W., P.T., W.A., D.M., E.A.J.C., C.E., E.T.O., E.R.A., A. Tijjani, K.M., A.F., B.R.F., A.Q., U.C. and P.W. provided samples and expertise for the studies’. This has been corrected in both the PDF and HTML versions of the Article
Photoreflectance and surface photovoltage spectroscopy characterisation of an InGaP/InGaAsN/GaAs NpN DHBT structure
No full textLate Quaternary alluvial fans, debris cones and talus cones in the Grampian Highlands, Scotland
No full textAlluvial fans, debris cones and rockfall talus cones
are widespread in upland Britain, but remarkably little is
known about their characteristics, development and
significance. This research project has three main
objectives:
1. to establish the morphological and surface sedimentary
characteristics of alluvial fans, debris cones and talus
cones in the Grampian Highlands of Scotland;
2. to identify the factors that have controlled their
formation and distribution; and
3. to determine the timing, nature and rate of fan- and
cone-forming processes.
On the basis of previous literature, an Orioni model
that describes a continuum of fan and cone morphological and
surface sedimentary properties was devised. The
applicability of this model was tested using data for six
variables (long profile gradient, slope form, downslope
changes in clast size, roundness and form, and a scale ratio
of maximum clast size to total fan or cone length) obtained
for fans and cones in the Grampian Highlands and the Lyngen
Peninsula in Northern Norway. The results of these tests
were then used to produce a modified model appropriate to
fans and cones in upland Britain.
Using a combination of map, field and aerial photograph
data, several environmental and morphometric controls on the
distribution and type of fan and cone development were
investigated. The dimensions of different types of fan and
cone are shown to be determined by basin morphometry,
lithology and glacial history. Discriminant analysis
identified basin gradient, basin width and basin height as
the principal catchment properties that influence the
dominant type of fan- or cone-forming process.
Stratigraphic and radiocarbon evidence suggests that
many debris cones are essentially paraglacial landforms that
formed in the earlier part of the Flandrian. Many of these
cones have subsequently been modified in the late Flandrian
by fluvial processes, in some cases in response to
anthropogenic interference. However, evidence from one site
has also revealed that substantial debris cone aggradation
has occurred since c 300 BP, implying high rates of
denudation in the recent past at this site. The volumes of
other debris cones imply that as much as 1-3m of surface
lowering has occurred in gullies upslope since deglaciation.
Much lower values of surface lowering are associated with
alluvial fan development, suggesting that, locally at least,
denudation by fluvial processes has been less significant
than denudation resulting from debris flow
Countable fan-tightness versus countable tightness
No full textsummary:Countable tightness is compared to the stronger notion of countable fan-tight\-ness. In particular, we prove that countable tightness is equivalent to countable fan-tightness in countably compact regular spaces, and that countable fan-tightness is preserved by pseudo-open compact mappings. We also discuss the behaviour of countable tightness and of countable fan-tightness under the product operation
Three years of Extreme Physiology & Medicine
No full text© 2015 Grocott and Montgomery. This article is distributed under the terms of the Creative Commons Attribution 4.0 Interna‑
tional License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in
any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Com‑
mons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecom‑
mons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated
The Malaysian Chinese homeland consciousness and Fang Beifang's novels
No full textThis article will discuss the transformation of homeland consciousness in Fang Beifang's novels against the background of the gradual localization of Malaysian Chinese literature. Begining with an immigrant identity in the early days, the Chinese gradually realized the importance of localization, and a patriotic consciousness emerged after Malaysia attained its independence. A prominent Malaysian Chinese author Fang Beifang based his works mainly on historical events, enriched with his personal experience and the flavor of the period. Fang Beifang's major works include The Trilogy of Wind and Cloud and The Trilogy of Torrent. The former is set during the anti-Japanese war in China, whereas the latter sums up his real life experiences in Malaya/Malaysia. His works record the Chinese's contribution to the development of Malaysia, as well as the national identity and political dilemmas faced by the Malaysian Chinese community
The subject of humanity and historical memory in the harmony of silk factory
No full textThe Harmony of Silk Factory is the debut novel of Tash Aw, who grew up in Malaysia, and is now living in London. This book won the Whitbread First Novel Award in 2005. The structure of the story set in the 1940s on Malay Peninsula is divided into 3 parts. Through multi-layered narrations, this book presents rarely seen Chinese capitalists, political communist activists and the complexity of identity in the Southeast Asian society during the British colonial rule and Japanese occupation. The present author aims to expose the real facts and truth that Malaysia' s government tries to avoid
Understanding individual and collective human mobility patterns in twelve crowding events occurred in Shenzhen
No full textFunding Information: P.W. and L.X. is supported by the National Natural Science Foundation of China (No. 71871224). Publisher Copyright: © 2022Crowding events, which pose tremendous pressure to city management and society safety, are a typical manifestation of anomalous human mobility in metropolitan areas. However, we are still lacking a comprehensive understanding of the anomalous human mobility in crowding events, which is crucial for preventing crowd disasters and developing sustainable cities and societies. In this study, we analyze the individual and collective human mobility patterns in crowding events using the smart card data of six million subway passengers in Shenzhen city. The discovered individual human mobility patterns reveal the underlying mechanism of crowd formation. The discovered collective human mobility patterns can be employed to anticipate crowding events, offering timely information for transportation and crowd management.Peer reviewe
Taxonomy and phylogeny of the genus Mycosphaerella and its anamorphs
No full textHistorically plant pathogenic species of Mycosphaerella have been regarded as host-specific, though this hypothesys has proven difficult to test largely due to the inavailability of fungal cultures. During the course of the past 20 years a concerted effort has been made to collect these fungi, and devise methods to cultivate them. Based on subsequent DNA sequence analyses the majority of these species were revealed to be host-specific, though some were not, suggesting that no general rule can be applied. Furthermore, analysis of recent molecular data revealed Mycosphaerella to be poly- and paraphyletic. Teleomorph morphology was shown to be too narrowly defined in some cases, and again too widely in others. Mycosphaerella and Teratosphaeria as presently circumscribed represent numerous different genera, many of which can be recognised based on the morphology of their 30 odd associated anamorph genera. Although Mycosphaerella is generally accepted to represent one of the largest genera of ascomycetous fungi, these data suggest that this is incorrect, and that Mycosphaerella should be restricted to taxa linked to Ramularia anamorphs. Furthermore, other anamorph form genera with Mycosphaerella-like teleomorphs appear to represent genera in their own right
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