169,756 research outputs found
Imaging of a Thymoma Incidentally Detected by C-11 Choline PET/CT
No full textThe integrated modality positron emission tomography/computed tomography (PET/CT) with C-11 choline is an established diagnostic tool for restaging prostate cancer patients with a biochemical failure after primary treatment. Thymoma is a rare tumor originating in thymus epithelial cells, asymptomatic in one-third to one-half of patients, and often occurring in the fourth and fifth decades of life. In the present case, C-11 choline PET/CT was performed in a prostate cancer patient with a biochemical relapse, to restage the disease. In addition to the detection of local recurrent disease in prostatic fossa, an abnormal C-11 choline increased uptake in mediastinum was reported. The mediastinal finding was initially wrongly interpreted by clinicians as a lymph nodal metastasis from prostate cancer. However, histopathological analysis confirmed the presence of a thymoma. Although rare, thymoma has to be considered as differential diagnosis in case of mediastinal masses presenting C-11 choline PET/CT positive findings, to avoid inappropriate patient management
[C-11]Choline PET/CT detection of bone metastases in patients with PSA progression after primary treatment for prostate cancer: comparison with bone scintigraphy
No full textPurpose The aim of this study was to evaluate the clinical usefulness of [C-11]choline positron emission tomography (PET)/CT in comparison with bone scintigraphy (BS) in detecting bone metastases (BM) of patients with biochemical progression after radical treatment for prostate cancer (PCa). Methods Seventy-eight consecutive patients with biochemical progression of PCa (mean prostate-specific antigen 21.1 ng/ml, range 0.2-500.0 ng/ml) referred for both [C-11]choline PET/CT and BS for restaging purposes were retrospectively analysed. The diagnostic accuracy of [C-11]choline PET/CT and BS was assessed by using morphological imaging and/or follow-up as standards of reference. As equivocal findings were found, the accuracy analysis was performed twice, once including them as positive and once as negative. A separate analysis was also performed in hormone-resistant patients and data compared with those of patients who did not receive anti-androgenic treatment. Results Equivocal findings occurred in 1 of 78 (1%) cases in [C-11]choline PET/CT and in 21 of 78 (27%) cases in BS. Depending on their attribution as either positive or negative, the ranges of sensitivity, specificity, positive predictive value, negative predictive value and accuracy for [C-11]choline PET/CT were 89-89%, 98-100%, 96-100%, 94-96% and 95-96%, respectively. For BS they were 100-70%, 75-100%, 68--100%, 100-86% and 83-90%, respectively. Concordant findings between [C-11]choline PET/CT and BS occurred in 55 of 78 (71%) cases. The accuracy of [C-11]choline PET/CT did not significantly (p = 0.30) differ between hormone-resistant patients (97%) and those who did not receive anti-androgenic treatment (95%). Conclusion In clinical practice, [C-11]choline PET/CT may not replace BS because of its lower sensitivity. However, for its high specificity, [C-11]choline PET/CT positive findings may accurately predict the presence of BM. Equivocal findings are more frequent in BS than [C-11]choline PET/CT
Strutture e linguaggi delle città mediterranee tra sintesi di forma e scambi d’oltremare
No full textStrutture e linguaggi delle città mediterranee tra sintesi di forma e scambi d’oltremare
No full textIncidental detection by [C-11]choline PET/CT of meningiomas in prostate cancer patients
No full textAim Anti-androgenic hormonal therapy in prostate cancer patients with concomitant meningioma may result m tumor growth and development of neurological symptoms. Positron emission tomography/computed tomography (PET/CT) with [C-11]choline is used for restaging prostate cancer patients with biochemical failure. In vitro and in vivo data support altered choline metabolism in meningiomas. Methods. During a retrospective study in prostate cancer patients with biochemical failure referred to our institution between November 2004 and Ja-nuary 2007, encephalic focal uptake of [C-11]choline was incidentally noted in 4 patients, 2 of which had been taking luteinizing hormone-releasing hormone analogs. Results. Subsequent to the incidental finding, one patient underwent surgical removal of the meningioma; strict neuroradiological follow-up was planned for the 3 other patients. Conclusion. We suggest that in prostate cancer patients candidate for anti-androgenic therapy the whole body [C-11]choline PET/CT scan should include the whole skull to check for the possible presence of meningiomas. This could help to identify patients at risk for the development of neurological symptoms during anti-androgenic therapy and help the referring urologist in the clinical management of these patients
Comparison of [C-11]Choline PET/CT and bone scintigraphy in the detection of bone metastasis in patients with biochemical failure after primary treatment for prostate cancer
No full textMisure di contrasto al fenomeno della segregazione sociale in area urbana
No full textIl volume raccoglie contributi di studiosi di diverse discipline sul fenomeno della segregazione sociale in area urbana con particolare riguardo alla situazione calabres
Reply to the letter "Choline PET/CT compared with bone scintigraphy in the detection of bone metastases in prostate cancer patients"
No full textArchitetture e trasformazioni. Giancarlo De Carlo e i "progetti tentativi" per il riuso del Monastero di S. Nicolò l'Arena a Catania
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