174,357 research outputs found
Reduced level of the histone deacetylase Sir2 in mRNA decapping mutants leads to silencing defects and premature aging
No full textRNA metabolism directly or indirectly impacts various cellular pathways.
Mutations in factors involved in mRNA decapping result in phenotypic markers of apoptosis and lead to premature aging. These traits are accompanied by elevated histone mRNA levels persisting throughout the cell cycle and defects in S-phase progression.
Here we show that decapping mutants exhibit low levels of Sir2, which reduces silencing and leads to the elevated transcription of rDNA intergenic spacer regions.
We postulate that defects in decapping are associated with the derepression of silencing at heterochromatic-like regions. This, in turn, may affect histone modification and induce loss of silencing at specific loci, as well as recombination within rDNA repeats, both of which have been shown to regulate cellular lifespan.
References
[1] Mazzoni C, Falcone C. Biochem Soc Trans. (2011), 39(5):1461-5. Review.
[2] Mroczek S & Kufel J (2008).Nucleic Acids Res 36, 2874-2888.
[3]Mazzoni C, Herker E, Palermo V, Jungwirth H, Eisenberg T, Madeo F & Falcone C (2005).EMBO Rep 6, 1076-108.
[4]Palermo V, Cundari E, Mangiapelo E, Falcone C & Mazzoni C (2010).Cell Cycle 9, 3991-3996.
[5] Thompson DM & Parker R (2007).Mol Cell Biol 27, 92-101
Per una rilettura di C. 1.14.12.5 e cost. Summa rei publicae § 3, in tema di fonti giurisprudenziali
No full textThe author suggests an explanation for the curious circumstance
(generally overlooked by scholars) that the famous constitution of
30 October 529 (C. 1.14.12), in which Justinian forcefully asserts
the exclusivity of the creation and interpretation of law in the hands
of the emperor, closes (§ 5) with the specification that this provision
does not in any way deprive the writings of the classical jurists of
their value, since the imperial maiestas itself recognised their creative-
interpretive role as well. In particular, the author hypothesises
that this specification was intended to dispel the misunderstanding
that the proclaimed imperial monopoly derogated what Justinian
himself had affirmed, a few months earlier (7 April), in the introductory
constitution of the Novus codex (c. Summa rei publicae § 3),
namely that, in addition to the imperial leges, the writings of the
classical jurists were also suitable ‘ad omnes dirimendas lites’
Endowing robots with self-modeling abilities for trustful human-robot interactions
No full textRobots involved in collaborative and cooperative tasks with humans cannot be programmed in all their functions. They are autonomous entities acting in a dynamic and often partially known environment. How to interact with the humans and the decision process are determined by the knowledge on the environment, on the other and on itself. Also, the level of trust that each member of the team places in the other is crucial to creating a fruitful collaborative relationship. We hypothesize that one of the main components of a trustful relationship resides in the self-modeling abilities of the robot. The paper illustrates how employing the model of trust by Falcone and Castelfranchi to include self-modeling skills in the NAO humanoid robot involved in trustworthy interactions. Self-modeling skills are then implemented employing features by the BDI paradigm
CTh. 1.2.10 - C. 1.20.1: un confronto testuale in tema di nascita dell'azione ab herede (tra Groningen e Palermo)
No full textAfter a recollection of the relations between the schools of Palermo and Groningen in the field of Byzantine
law, which were fostered by Jan Lokin, and of the scientific profile of the late scholar, the author
tackles a textual comparison between the versions of a constitution of Arcadius preserved in the Theodosian
Codex and in the Justinian Codex of 534. In the latter, the concluding statement of Arcadius’s lex,
which contained the rule that an action cannot be commenced by the heir of a person who had not been
the holder of the same action, was eliminated by the compilers of 534: it was in fact in contrast to a constitution
of Justinian of 531, which, on the contrary, stated that actions can be commenced by and
against heirs and which, in substance, reiterated a provision already issued in 528. A passage from the Basilics,
generally overlooked by scholars, shows that Arcadius’ constitution had already been included in the
Code of 529 and that it also contained the rule deleted in 534. Evidently, the compilers of the first Justinian
Code had not taken the lex of 528 into account and this circumstance probably explains the very insistent
and resolute wording with which Justinian in 531 expressly abolished the rule enunciated by Arcadius.
This also explains the presence in the 534 Code of both Justinian’s constitutions of 528 and 531,
which has been the object of discussion among scholars
From Manifesta to Krypta: The Relevance of Categories for Trusting Others
No full textIn this paper we consider the special abilities needed by agents for assessing trust based on inference and reasoning. We analyze the case in which it is possible to infer trust towards unknown counterparts by reasoning on abstract classes or categories of agents shaped in a concrete application domain. We present a scenario of interacting agents providing a computational model implementing different strategies to assess trust. Assuming a medical domain, categories, including both competencies and dispositions of possible trustees, are exploited to infer trust towards possibly unknown counterparts. The proposed approach for the cognitive assessment of trust relies on agents' abilities to analyze heterogeneous information sources along different dimensions. Trust is inferred based on specific observable properties (Manifesta), namely explicitly readable signals indicating internal features (Krypta) regulating agents' behavior and effectiveness on specific tasks. Simulative experiments evaluate the performance of trusting agents adopting different strategies to delegate tasks to possibly unknown trustees, while experimental results show the relevance of this kind of cognitive ability in the case of open Multi Agent Systems
Nuova Scuola Primaria “Falcone - Borsellino”
No full textIl progetto per la Nuova Scuola Primaria “Falcone - Borsellino", sita ad Ascoli Piceno (AP), è risultato vincitore del concorso di progettazione in due gradi, Missione 2 – Componente 3 – Investimento 1.1 “Costruzione di nuove scuole mediante sostituzione di edifici” del Piano nazionale di ripresa e resilienza (PNRR), finanziato dall’Unione europea – Next Generation EU (CIG 9291045CDF, Codice 2° grado AEAP100A).
La nuova Scuola Primaria “Falcone – Borsellino” è una scuola di piccole dimensioni che ha il grande compito di costruire un polo civile all’interno di un tessuto residenziale, un luogo destinato non soltanto alla comunità scolastica ma agli abitanti del quartiere che qui possono ritrovarsi e riconoscersi. L’idea di progetto è quella di costruire una sequenza di luoghi collettivi, dai più pubblici a quelli destinati alla didattica, connessi tra loro, visibili e riconoscibili. La scuola è così composta da quattro luoghi – una piazza di accesso, un atrio/piazza coperta, un giardino alberato e un edificio della didattica, sospeso sopra di essi.
La sostenibilità è perseguita nel progetto attraverso l’utilizzo di soluzioni altamente innovative: l’impiego di materiali a basso impatto ambientale, quali pannelli isolanti in fibra di canapa, la scelta di impianti a ridotto consumo energetico e lo sfruttamento delle risorse rinnovabili hanno permesso di realizzare un edificio altamente efficiente e performante che configura il complesso non solo come nZEB ma come edificio attivo.
Infatti, la riduzione dei carichi termici minimizza la potenza dei generatori (riduzione del 60% dei fabbisogni rispetto all’edificio di riferimento) e garantisce fabbisogni globali di energia primaria inferiori a 100 kWh/(anno m2). Il consumo di energia primaria calcolato EPgl,tot è di oltre il 60% inferiore alla soglia fissata per il requisito NZEB previsto dalla normativa italiana. Il fotovoltaico (48 kWp) genera, su base annua, circa 46.300 kWh coprendo e superando i fabbisogni richiesti dall’edificio, rendendo la scuola largamente attiva.
Al fine di ottimizzare la contemporaneità tra produzione ed uso dell’energia, l’impianto in oggetto è completato da un sistema di accumulo a batterie per i cicli di breve durata (giorno/notte, weekend) ed uno di produzione di idrogeno integrato da fuelcell/microcogenerazione per i cicli più lunghi.
Gli impianti fluidomeccanici della scuola sono pensati per garantire la possibilità di regimi termici a “bassa temperatura invernale” ed "alta temperatura estiva” al fine di consentire la massima efficienza con sistemi di generazione del tipo a pompa di calore geotermica ad acqua di falda.
L’installazione di un BMS auto adattivo consente di monitorare tutte le componenti impiantistiche garantendo sia il raggiungimento di elevati livelli di comfort che la riduzione dei consumi energetici, oltre ad una semplificazione della manutenzione e della gestione del complesso.
Il comfort luminoso è garantito da sistemi a LED “blue-hazard-free”, mentre il controllo dell’illuminazione avviene grazie ad un sistema DALI.
Inoltre, l’impiantistica della nuova Scuola risponde ai requisiti richiesti dalla certificazione LEED Platinum
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