1,721,054 research outputs found
Safety of laparoscopy vs laparotomy in the surgical staging of endometrial cancer: A systematic review and metaanalysis of randomized controlled trials
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Management strategies for ovulation induction in women with polycystic ovary syndrome and known clomifene citrate resistance
No full textPurpose of reviewClomifene citrate is the first and the most used agent for inducing ovulation in patients affected by polycystic ovary syndrome (PCOS). About 60-85% of PCOS women ovulated under clomifene citrate, whereas the others were defined clomifene citrate-resistant. The purpose of the current review will be to describe treatment strategies to induce ovulation in infertile PCOS patients with clomifene citrate resistance.Recent findingsClomifene citrate and metformin association are a valid option for inducing ovulation in clomifene citrate-resistant PCOS patients. Surgical ovulation induction by laparoscopic ovarian drilling should be reserved to well selected cases. Excellent preliminary results are obtained using new drug formulations, such as aromatase inhibitors.SummaryIn clomifene citrate-resistant PCOS patients, clomifene citrate and metformin combination and laparoscopic ovarian drilling, in selected cases, should be considered before gonadotropin administration. The efficacy of the other treatments must be confirmed in future well designed studies
Safety and efficacy of the minilaparotomy for myomectomy: A systematic review and meta-analysis of randomized and non-randomized controlled trials
No full textMyomectomy is the most frequent reproductive surgery to preserve, improve fertility, or both. The present study was designed to assess the safety and efficacy of minilaparotomy for myomectomy through a systematic review of randomized and non-randomized controlled trials with a meta-analysis. All available studies comparing minilaparotomy myomectomy with laparotomy, other minimally invasive surgeries, or both, were included. Available surgical and reproductive data were extrapolated, and a qualitative and quantitative analysis was carried out. Fourteen studies were included in the final analysis for an overall sample of 2151 patients. A total of 1139 patients were treated with minilaparotomy, whereas 239 and 773 patients were treated, respectively, with the laparotomy or laparoscopy. Only two studies comparing minilaparotomy with laparoscopy assessed the reproductive outcomes, and their data synthesis did not demonstrate significant difference between the two surgical techniques. Specific surgical end-points differed significantly between minilaparotomy and laparotomy or laparoscopy, even if those differences were not clinically relevant. In conclusion, current data do not permit a definite conclusion to be drawn. Further studies are needed to clarify the risk-benefit ratio of the minilaparotomy compared with the other minimally invasive surgical procedures for myomectomy to provide clinical recommendations with strong scientific evidence
Effect of preconceptional metformin on abortion risk in polycystic ovary syndrome: a systematic review and meta-analysis of randomized controlled trials
No full textLaparoscopic treatment for endometrial cancer: A meta-analysis of randomized controlled trials (RCTs)
No full textUpdating of a recent meta-analysis of randomized controlled trials to assess the safety and the efficacy of the laparoscopic surgery for treating early stage endometrial cancer
No full textrecent meta-analysis of randomized controlled
trials to assess the safety and the efficacy of the laparoscopic
surgery for treating early stage endometrial cance
Evidence-based and potential benefits of metformin in the polycystic ovary syndrome: A comprehensive review
No full textIs endometrial receptivity impaired in women with polycystic ovary syndrome?
No full textWomen with polycystic ovary syndrome (PCOS) seem to have impaired reproductive performances. It is generally considered that an altered ovulatory function is the main cause of infertility in the affected women. However, other factors may play a role in the pathogenesis of the PCOS-related infertility. During the last years, more and more importance has been given to endometrium as contributor of the PCOS-related subfertility. In the present narrative review, the main and recent experimental and clinical data will discuss in order to clarify the role played by the endometrium in the PCOS-related subfertility. The overall analysis of available data suggests that, in women with PCOS, the endometrium is primarily affected, and closely and deeply influenced by the several hormonal, metabolic, clinical alterations related to the syndrome
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