96 research outputs found
Influencia de la ingesta de polifenoles en el desarrollo de diferentes tipos de cáncer: estudio multicaso-control MCC Spain = Influence of polyphenol intake in the development of different types of cancer: a multicase-control study MCC Spain
No full text281 p.El objetivo principal de esta tesis doctoral es evaluar la influencia del consumo de PF en el desarrollo de cáncer de mama y cáncer gástrico, en el marco del proyecto MCC-Spain.
La presente tesis se enmarca en dos proyectos, el estudio nacional Multicaso-control - MCC-Spain y el consorcio internacional Stomach cancer Pooling Project (Stop-Project) cuyos datos han sido utilizados para realizar distintos estudios sobre el efecto de los PF en el desarrollo de distintos tipos de cáncer y en el cual también está presente el proyecto MCC-Spain
Flavonoids and the Risk of Gastric Cancer: An Exploratory Case-Control Study in the MCC-Spain Study
No full textSeveral epidemiological studies have investigated the association between the dietary
flavonoid intake and gastric cancer (GC) risk; however, the results remain inconclusive. Investigating
the relationship between the different classes of flavonoids and the histological types and origin of
GC can be of interest to the research community. We used data from a population-based multi-case
control study (MCC-Spain) obtained from 12 different regions of Spain. 2700 controls and 329 GC
cases were included in this study. Odds ratios (ORs) were calculated using the mixed e ects logistic
regression considering quartiles of flavonoid intakes and log2. Flavonoid intake was associated
with a lower GC risk (ORlog2 = 0.76; 95% CI = 0.65–0.89; ORq4vsq1 = 0.60; 95%CI = 0.40–0.89;
ptrend = 0.007). Inverse and statistically significant associations were observed with anthocyanidins,
chalcones, dihydroflavonols and flavan-3-ols. The isoflavanoid intake was positively associated with
higher cancer risk, but without reaching a statistical significance. In general, no differences were
observed in the GC risk according to the location and histological type. The flavonoid intake seems
to be a protective factor against GC within the MCC-study. This effect may vary depending on the
flavonoid class but not by the histological type and location of the tumor. Broader studies with larger
sample size and greater geographical variability are necessary.The study was partially funded by the “Accion Transversal del Cancer”, approved on the Spanish
Ministry Council on 11 October 2007, by the Instituto de Salud Carlos III-FEDER (PI08/1770, PI08/0533,
PI08/1359, PS09/00773-Cantabria, PS09/01286-León, PS09/01903-Valencia, PS09/02078-Huelva, PS09/01662-Granada,
PI11/01403, PI11/01889-FEDER, PI11/00226, PI11/01810, PI11/02213, PI12/00488, PI12/00265, PI12/01270, PI12/00715,
PI12/00150, PI14/01219, PI14/0613, PI15/00069, PI15/00914, PI15/01032, PI17CIII/00034), by the Fundación Marqués de Valdecilla (API 10/09), by the ICGC International Cancer Genome Consortium CLL (The ICGC CLL-Genome
Project is funded by Spanish Ministerio de Economía y Competitividad (MINECO) through the Instituto de
Salud Carlos III (ISCIII) and Red Temática de Investigación del Cáncer (RTICC) del ISCIII (RD12/0036/0036)), by
the Junta de Castilla y León (LE22A10-2), by the Consejería de Salud of the Junta de Andalucía (PI-0571-2009,
PI-0306-2011, salud201200057018tra), by the Conselleria de Sanitat of the Generalitat Valenciana (AP_061/10),
by the Recercaixa (2010ACUP 00310), by the Regional Government of the Basque Country, by the Consejería de
Sanidad de la Región de Murcia, by the European Commission grants FOOD-CT-2006-036224-HIWATE, by the
Spanish Association Against Cancer (AECC) Scientific Foundation – grant GCTRA18022MORE, by the Catalan
Government- Agency for Management of University and Research Grants (AGAUR) grants 2017SGR723 and
2014SGR850, by the Fundación Caja de Ahorros de Asturias and by the University of Oviedo. ISGlobal is a
member of the CERCA Programme, Generalitat de Catalunya
Le iscrizioni pro salute imperatoris nella provincia romana di Dalmazia
No full textThe author analyses the inscriptions from the province with the formula pro salute
imperatoris. This can not be taken as a proof of imperial cult, but of loyalty to the
imperial power. It is interesting to notice the geographic and chronologic distribution
of the documents, from which we see that they come mainly from official ambiences,
connected to imperial property or army. Anyway are worth remarking also documents
erected by private people or municipalities who related their welfare with that of the
emperor. The biggest concentration of testimonies is under the Severian dynasty, as
already verified elsewhere
Validation of self-reported perception of proximity to industrial facilities: MCC-Spain study
No full textThisstudy was funded by:Scientific Foundation of the Spanish Association Against Cancer (Fundación Científica de la Asociación Española Contra el Cáncer(AECC)– EVP-1178/14), Spain's Health Research Fund (Fondo de Investigación Sanitaria–FIS12/01416),the Spanish Ministry of Economy and Competitiveness (Carlos III Institute of Health; PI12/00488, PI12/00265, PI12/01270, PI12/00715,PI12/00150,PI08/1770,PI08/0533,PI08/1359,PS09/00773,PS09/01286, PS09/01903, PS09/02078, PS09/01662, PI11/01403,PI11/01889, PI11/00226, PI11/01810, PI11/02213, PI14/01219 and Río Hortega CM13/00232),the Catalan Government 2009 SGR1489&2014SGR756-F,the Fundación Marqués de Valdecilla(API10/09),the ICGC International Cancer Genome Consortium CLL, the Junta de Castilla y León (LE22A10-2), the Consejería de Salud of the Junta de Andalucía (PI-0571), the Conselleria de Sanitat of the Generalitat Valenciana (AP 061/10), the Recercaixa (2010ACUP 310), and the Regional Government of the Basque Country by European Commission grants FOOD-CT-2006-036224-HIWATECastello, A; Perez-Gomez, B; Lora-Pablos, D; Lope, V; Castano-Vinyals, G; Vitelli-Storelli, F; Dierssen-Sotos, T; Amiano, P; Guevara, M; Moreno, V; Lozano-Lorca, M; Tardon, A; Alguacil, J; Hernandez-Garcia, M; Marcos-Gragera, R; Lopez, MDC; Ardanaz, E; Ibarluzea, J; Gomez-Acebo, I; Molina, AJ; O'Callaghan-Gordo, C; Aragones, N; Kogevinas, M; Pollan, M; Garcia-Perez, J
Qualche considerazione storica sulle ghiande missili di Ossero/Osor: in margine a CIL I2, 887; 888
No full textIl contributo è incentrato su due ghiande missili plumbee romane iscritte, ritrovate a Ossero, nel golfo del Quarnaro, nel 1878, assieme ad altre 20 anepigrafi. Furono pubblicate nei corpora epigrafici, ma poi andarono disperse. L’autore riconsidera le letture, propone una nuova interpretazione, indi svolge delle considerazioni storiche sulla circostanza a cui possono risalire i reperti. Alla luce della posizione strategica di Apsorus per le rotte marittime nell’Adriatico orientale, non stupisce che la città sia stata centro di un assedio tra la tarda Repubblica e l’epoca augustea. Tra le ipotesi quella che si ritiene più probabile è che le ghiande siano state utilizzate durante la guerra civile tra Cesare e Pompeo.The contribution is devoted to two Roman inscribed lead sling-shots, which were found in 1878 in Ossero (modern Osor), located in Kvarner Gulf, together with other 20 anepigraphic. The inscribed ones were published in the epigraphic corpora and afterwards went lost. The author reconsiders the readings and proposes also a new interpretation; then, he makes some considerations about the events to which the findings can be related. Because of its strongly strategic location along the maritime routes of Eastern Adriatic, is not surprising that Apsorus was besieged between late Republic and Augustan age. Among the hypotheses the author sees the civil war between Cesar and Pompey as the most probable one
The knowledge of the edges of the world in Strabo’s work as a result of Roman conquests: some reflections based on Str. 1.2.1 and 2.5.12
No full textDuring the first century BC, the most remote regions of the oikoumene were directly known thanks to the Roman military expeditions. Strabo, who had the intention to describe the whole world following Augustus’ ideology, received and accepted a lot of this recent information unknown to the previous historiographers, above all Polybius and Posidonius. I pay attention firstly to which improvement he brings to the previous knowledge in regions newly discovered, secondly which way he presents the inhabitants of these areas. In order to answer the questions, the focus is especially on Northern Europe, among the regions announced as new discoveries by the author at the beginning of his work
Il transito degli Argonauti nell’Adriatico settentrionale e centrale: note geografiche ad A.R. 4. 335-587
No full textThe author traces the sea route of the Argonauts along the eastern Adriatic coast from the Quarnaro to Planca Cape, as described in the Argonautica by Apollonius of Rhodes. The focal points of this text are:
- The confirmed identification of the two Brigeides islands with Cherso e Lussino in the light of new data;
- The localization of the Hylloi in the Zara peninsula;
- The new identification of Dyskélados with the island of Zuri because of its etymon which could refer to dangerous navigational point and because of rich shipwrecks found around it
La battaglia del Canale di Maltempo/Tihi kanal (49 a.C.) nel golfo del Quarnaro/Kvarner: note topografiche
No full textThis paper will offer a new reconstruction of the battle between Caesarians and Pompeians in the Tihi kanal (49 BC). In particular, the possibility that
Antonius’ forces under siege in the Bejavac peninsula built the rafts for escaping from Krk will be considered. Moreover,
it seems unlikely that the Pompeian soldiers saw the enemies while they were setting out to evacuate and did nothing
to stop them. Therefore, either the view of the preparations was prevented by an obstacle, like a hill, or the Caesarians
built the rafts, hidden in the fortifications discovered along the northern side of Voz Bay. As for the final battle and the
suicide of the Venetian Opitergians, this can plausibly be located on the small island of Sv. Marko, although no mention
of this particular is made by our sources, or on the mainland. Apropos this, the author also hypothesizes that the
Caesarian reinforcements led by Basilus, who had their encampment on the mainland, had been previously defeated by
the Pompeians
Effect of polyphenol intake on biomarkers and cardiovascular risk
No full text174 p.[ES] Introducción La enfermedad cardiovascular es la principal causa de muerte en todo el mundo y, a pesar de las estrategias preventivas llevadas a cabo, continúa siendo un problema de salud pública. La dieta mediterránea ha demostrado numerosos beneficios cardiosaludables dada su riqueza en moléculas antioxidantes y antiinflamatorias y, muy especialmente, en polifenoles. Estos compuestos bioactivos han mostrado beneficios a nivel cardiovascular debido a sus propiedades antitrombóticas, antiinflamatorias y antiagregantes. Sin embargo, el estudio de su potencial en humanos es limitado. Dado el gran número de compuestos que existen, y, por ende, sus variadas biodisponibilidades y mecanismos de acción, aún hay muchos puntos que necesitan ser esclarecidos. Por este motivo, el objetivo principal de la presente tesis doctoral es evaluar la asociación entre el consumo de polifenoles, y el riesgo y biomarcadores de riesgo cardiovascular (RCV).
Metodología Se utilizó la información disponible de 6.633 participantes del estudio PREDIMED-Plus, un ensayo clínico aleatorizado multicéntrico, que recopiló información sobre hábitos alimentarios y estilos de vida, así como muestras sanguíneas para análisis bioquímicos. El consumo de polifenoles se estimó utilizando los datos de consumo de alimentos del cuestionario semicuantitativo de frecuencia alimentaria de 143 ítems y el contenido de polifenoles de cada alimento contenido en la base de datos Phenol-Explorer. Los consumos estimados se ajustaron por la ingesta total de energía de acuerdo al método de residuales.
Mediante modelos de regresión lineal multivariante, se evaluó la asociación entre la ingesta de polifenoles y el RCV (estimado mediante ecuaciones de riesgo). Además, se evaluó la asociación entre la ingesta de polifenoles y, el ácido úrico (mediante regresión lineal multivariante) y, mediante modelos de regresión de Cox con un tiempo de seguimiento constante (t=1) se estimó los Prevalence Ratio de la hiperuricemia.
Por otro lado, se establecieron patrones de consumo de polifenoles mediante análisis factorial y análisis clúster, comparando ambos métodos y relacionando la adherencia a cada patrón con el RCV estimado.
Todos los análisis se realizaron para hombres y mujeres por separado, además de en la población total.
Resultados La ingesta total de polifenoles (βQ5vs.Q1= 0,10, IC 95%: 0,04 a 0,17) y flavonoides (βQ5vs.Q1= 0,17, IC 95%: 0,10 a 0,24) se asoció directa y significativamente con una mejor salud cardiovascular óptima (Life’s Simple 7). Se encontraron asociaciones inversas entre el consumo de la clase otros polifenoles y, el RCV estimado mediante Framingham (βQ5vs.Q1= -1,22%, IC 95%: -2,37 a -0,07) y SCORE (βQ5vs.Q1=-0,32, IC 95%: -2,37 a -0,07). En las mujeres, las asociaciones entre el consumo de polifenoles y todas las ecuaciones de riesgo, tienden a ser protectoras.
La ingesta de ácidos fenólicos (βQ5vs.Q1= -0,17, IC 95%: -0,27 a -0,06), ácidos hidroxicinámicos (βQ5vs.Q1= -0,19, IC 95%: -0,3 a -0,09), alquilmetoxifenoles (βQ5vs.Q1= 0,2, IC 95%: -0,31 a -0. 1) y metoxifenoles (βQ5vs.Q1= -0,24, IC 95%: -0,34 a -0,13) -0,24, IC 95%: -0,34 a -0,13) mostró una asociación inversa con los niveles de ácido úrico en suero y, la hiperuricemia (PRQ5vs.Q1=0,82, IC 95%:0,71-0,95; PRQ5vs.Q1=0,82, IC 95%:0,71-0,95; PRQ5vs.Q1=0,80, IC 95%:0,70-0,92 y PR=0,79, IC 95%:0,69-0,91, respectivamente).
Los patrones de polifenoles revelaron diferencias entre hombres y mujeres, así como en su asociación con el RCV. Respecto a aquellos derivados del análisis factorial: para el total de la muestra, y los hombres, el patrón 3 (aceitunas y aceite de oliva) se asoció positivamente con el RCV, también presentaron, mayor prevalencia de diabetes y mayores consumos de sodio. El patrón 4 formado por el café en todos los grupos, también se asoció con mayor RCV. En cuanto al análisis clúster, el clúster 2 en el total y en hombres, caracterizados por consumo de polifenoles del café y las aceitunas y aceite de oliva, también mostraron mayor RCV.
Conclusiones La clase otros polifenoles mostró asociaciones inversas con el riesgo cardiovascular estimado, encontrándose resultados similares con las ecuaciones de Framingham, Framingham-REGICOR y Life’s Simple 7 (después de eliminar el componente de dieta) y diferentes con la SCORE, pero los predictores que se incluyen en esta herramienta son escasos.
Una mayor ingesta subclases de polifenoles presentes en el café: ácidos hidroxicinámicos, alquilmetoxifenoles y metoxifenoles se asoció de forma inversa a los niveles de ácido úrico y la hiperuricemia.
Encontramos diferencias en los patrones de ingesta de polifenoles entre hombres y mujeres, y en sus asociaciones con la RCV. Estas diferencias de sexo pueden explicarse por el hecho de que llevan estilos de vida diferentes, ya que un patrón no se refiere sólo a los hábitos dietéticos.
Además, los sujetos que presentaban un mayor riesgo al inicio del estudio podrían sentirse más motivados para mejorar su hábito dietético (causalidad inversa).
Nuestros hallazgos añaden nuevos conocimientos en el estudio de los compuestos fenólicos, destacando la importancia de analizarlos por sexo y de estudiar los determinantes de las elecciones alimentarias y los patrones dietéticos en relación con la percepción de riesgo y los estilos de vida específicos.[EN] Introduction Cardiovascular disease is the leading cause of death worldwide and, despite preventive strategies, continues to be a public health problem. The Mediterranean diet has demonstrated numerous benefits in this regard given its richness in antioxidant and anti-inflammatory molecules, and most especially, in polyphenols. These bioactive compounds have shown cardiovascular benefits due to their antithrombotic, anti-inflammatory and antiplatelet properties. However, the study of their potential in humans is limited. Given the large number of compounds that exist and, therefore, their varied bioavailability and mechanisms of action, there are still many points that need to be clarified. For this reason, the main objective of this doctoral thesis is to evaluate the association between polyphenol intake and cardiovascular risk (CVR) and biomarkers.
Methods The information available from 6,633 participants in the PREDIMED-Plus study was used, it is a multicenter randomized clinical trial, which collected information on dietary habits and lifestyles, as well as blood samples for biochemical analysis. Polyphenol intakes were estimated using food consumption data from the 143-item semi-quantitative food frequency questionnaire and the polyphenol content of each food contained in the Phenol-Explorer database. Estimated intakes were adjusted for total energy intake according to the residuals method.
The association between polyphenol intake and CVR (estimated using risk equations) was evaluated using multivariate linear regression models. In addition, the association between polyphenol intake and uric acid was evaluated (using multivariate linear regression) and, using Cox regression models with a constant follow-up time (t=1), the prevalence ratio of hyperuricemia was estimated.
On the other hand, polyphenol consumption patterns were established by factor analysis and cluster analysis, comparing both methods and relating adherence to each pattern with the estimated CVR.
All analyses were performed for men and women separately, as well as in the total population.
Results Total polyphenol (βQ5vs.Q1= 0.10, 95% CI: 0.04 to 0.17) and flavonoid (βQ5vs.Q1= 0.17, 95% CI: 0.10 to 0.24) intakes were directly and significantly associated with improved optimal cardiovascular health (Life's Simple 7). Inverse associations were found between other polyphenols class intake and, CVR estimated by Framingham (βQ5vs.Q1= -1.22%, 95% CI: -2.37 to -0.07) and SCORE (βQ5vs.Q1=-0.32, 95% CI: -2.37 to -0.07). In women, the associations between polyphenol intake and all risk equations tended to be protective.
The intake of phenolic acids (βQ5vs.Q1= -0.17, 95% CI: -0.27 to -0.06), hydroxycinnamic acids (βQ5vs.Q1= -0.19, 95% CI: -0.3 to -0.09), alkylmethoxyphenols (βQ5vs.Q1= 0.2, 95% CI: -0.31 to -0. 1) and methoxyphenols (βQ5vs.Q1= -0.24, 95% CI -0.34 to -0.13) showed an inverse association with serum uric acid levels and, hyperuricemia (PRQ5vs.Q1=0.82, 95% CI:0.71-0.95; PRQ5vs.Q1=0.82, 95% CI:0.71-0.95; PRQ5vs.Q1=0.80, 95% CI:0.70-0.92 and PRQ5vs.Q1=0.79, 95% CI:0.69-0.91, respectively).
The polyphenol patterns revealed differences between men and women, as well as, in their association with CVR. Regarding those derived from the factorial analysis: for the total sample and the men, pattern 3 (olives and olive oil poyphenols) was positively associated with CVR, they also had a higher prevalence of diabetes and higher sodium intake. Pattern 4, formed by coffee polyphenols in all groups, was also associated with higher CVR. As for the cluster analysis, cluster 2 in the total and in men, characterized by consumption of coffee polyphenols and olives and olive oil, also showed higher CVR.
Conclusions The other polyphenols class showed inverse associations with estimated cardiovascular risk, finding similar results with the Framingham, Framingham-REGICOR and Life's Simple 7 equations (after eliminating the diet component), and different with the SCORE, but predictors included in this scale are scarce.
Higher intakes of polyphenols present in coffee: hydroxycinnamic acids, alkylmethoxyphenols, and methoxyphenols, were inversely associated with serum uric acid levels and hyperuricemia.
We found differences in polyphenol intake patterns between men and women, and in their associations with CVR. These sex differences may be explained by the fact that they lead different lifestyles, since a pattern does not refer only to dietary habits. Moreover, subjects who were at higher risk at baseline might be more motivated to improve their dietary habit (reverse causality).
Our findings add new insights in the study of phenolic compounds, highlighting the importance of analyzing them by sex and studying the determinants of food choices and dietary patterns in relation to risk perception and specific lifestyles
Quali centri abitati nell'Illirico di Strabone? Appunti per un'indagine
No full textIl breve contributo è dedicato agli insediamenti attestati nella sezione illirica della Geografia di Strabone (VII 5, 1-12): sono all’incirca 20 e offrono una grande varietà di tipologia, dalle città costiere alle fortezze d’altura. Come osservato per altre regioni, l’autore è attento al fenomeno urbano, ma le denominazioni cambiano e non emerge chiaramente un criterio nella scelta e nella classificazione dei centri, attribuibile anche all’assenza di un’armonizzazione tra le fonti seguite. È sorprendente che manchi ogni riferimento alle colonie romane dell’Adriatico orientale, certamente già dedotte quando venne composta l’opera.In this short contribution, the author pays attention to the settlements attested in the Illyrian section of Strabo's Geography (VII 5, 1-12). They are about 20 in total and present different labels and entities, from the fortresses to the coastal towns of Mediterranean style. As in most regions, it emerges that, despite the importance ascribed to the idea of polis within the work, what is missing is a final consistency in choosing and listing the settlements, given that is not interested either in updating or harmonizing the available sources. A striking aspect is the absence of the colonies along the Adriatic coast, which were for sure already established when Strabo wrote his Geography
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