717 research outputs found
Fra Cardillo e ZEN. Incrocio tra via Fabio Besta e via Lanza di Scalea
No full textLa via Fabio Besta, preesistente collegamento fra la borgata di Cardillo e il quartiere ZEN, è interrotta dalla via Lanza di Scalea in prossimità dello ZEN 1. La frattura è resa più evidente a causa di un salto di quota.
La soluzione di continuità è legata alla profonda differenza fra le due arterie; infatti mentre la via Fabio Besta deriva da un tracciato più antico e minuto, la via Lanza di Scalea fa parte di un sistema di infrastrutture ad alta
velocità, realizzato per l’edizione dei mondiali di calcio del ’90, che collega la zona nord della città all’autostrada.
Bisogna invertire i termini rispetto alla situazione attuale e attribuire alle infrastrutture viarie in prossimità dei quartieri periferici un carattere urbano in grado di prevalere sulla connotazione di strade extraurbane. Si ritiene perciò necessario distendere un filo continuo fra Cardillo e ZEN che, intercettando la via Lanza di Scalea, dovrebbe rallentare la velocità dei veicoli e suggerire l’ingresso al quartiere. Tale incrocio potrà essere risolto, per esempio, con una rotonda o con un altro sistema in grado di rendere compatibili e sicuri i due flussi veicolari fra loro perpendicolari. Insieme al tema del nodo infrastrutturale bisognerà risolvere la continuità pedonale fra Cardillo
e ZEN. Si tratta di un progetto di suolo in grado di coinvolgere e riqualificare anche le aree disposte lungo i margini della via Lanza di Scalea e vicino alla via Fabio Besta, che il P.R.G. prevede come spazi pubblici a verde
(zona V3). La rete stradale è parte dello spazio pubblico, che si affianca ai luoghi di sosta. Tale connotazione non deve essere annullata dall’aspetto meramente funzionale di canale di scorrimento. Il sistema delle vie Lanza
di Scalea e Besta e gli spazi limitrofi possono esprimere nuove centralità
Fra Cardillo e Zen. Incrocio fra via Fabio Besta e via Lanza di Scalea
No full textLa scheda descrive uno dei dodici temi di progetto del Prin 2007. In particolare, tratteggia le questioni relative alla relazione fra la borgata di Cardillo e il quartiere Zen di Palermo
Flow survey of a forward curved blades centrifugal fan for HVAC applications
No full textThe advancements in fan technology are nowadays animated by two major drivers: The legal requirements that impose minimum fan efficiency grades for fans sold within European Union (and soon US and Asia), and the market request for better air performance and lower sound emissions. Within HVAC (Heating, Ventilating and Air Conditioning) applications, centrifugal fans with forward curved blades are widely used due to the higher total pressure rise capability and lower acoustic emissions with respect to more efficient backward curved blades. However the continuous rise of minimum fan efficiency grades pushes the manufacturers to develop a new generation of forward curved centrifugal fans, improving previous design. Here the challenge is not only on aerodynamics, but in the overall production process, as squirrel cage fans are characterised by a cost-effective consolidated technology, based on simple blade geometries and easy series manufacturing. For example, the blades usually have circular camber lines, as results of cut cylinders. Thus, once the number of blades and the angle at the leading edge are selected, the chord and the deflection capability are constrained as well. These concurring aspects led industry to include in the design process new tools, in particular CFD, to analyse the flow features of the current generation of fans in order to understand which phenomena are to be either controlled or exploited to increase efficiency and total pressure rise. Here we present a numerical investigation on a forward curved blade centrifugal fan for HVAC applications, to highlight the flow features inside the impeller and in the critical region of coupling with the volute. The analysis was carried out with OpenFOAM, an open-source library for CFD. Computations were performed with the frozen rotor approach and validated against available experimental data
NUTRITIONAL FLAVONOIDS MODULATE ESTROGEN RECEPTORS SIGNALING
No full textEstrogen receptors (ER and ER mediate 17-estradiol (E2) actions through the transcription of E2-sensitive target genes. In addition, rapid non-genomic signaling (e.g., MAPK/ERK, PI3K/AKT) occurs. It is now well accepted that these rapid membrane-initiated responses account for E2-related proliferation. Beside many beneficial effects on human health, nutritional flavonoids exert protective and antimitogenic effects on E2-related proliferation. The mechanism(s) underlying these effects seems to be related to flavonoids antioxidant properties and/or to their ability to alter signal transduction protein kinases. In addition, an antiestrogenic activity has been proposed but not yet defined. However, the identification and characterization of the responsible mechanisms for flavonoid antitumoral effects is poorly understood. Here, we investigated the possibility that the antimitogenic effects of flavonoids are transduced by modulating ERs-mediated rapid signaling. The ability of two flavonoids, the flavanone naringenin and the flavanol quercetin, abundant in Mediterranean diet, to induce ERs activities has been studied with respect of E2. Our results indicate that flavonoids act as E2 mimetic on ER transcriptional activity, whereas they impair the activation of rapid signalling pathways committed to E2-induced proliferation. The resulting decoupling of ER signal transduction could be proposed as a new mechanism in the protective effects of flavonoids against E2-related proliferation
Pattern and path encoding: new tool for unwelding visuo-spatial memory through the use of a sensorized platform
No full textIt has been demonstrated that the processing of visuospatial information in reaching or navigational space is supported by independent systems.
Moreover, it has been proposed that visuospatial information may require a pattern or a path encoding. The pattern encoding is specifically used when the task requires a simultaneous processing of spatial positions, while the path encoding is used in sequential processing that allows to link different spatial positions in correct succession.
The aim of the present study was to disentangle these different components of visuospatial information processing in navigational tasks by the development of an innovative sensorized platform, and to verify if subjects use the same strategies when similar tasks are performed in reaching space. We assessed the performance of 70 healthy volunteers on the sensorized platform to investigate topographical orientation (route memory) in three different tasks that required a sequential strategy (named Route A and Route B tasks, which differ for sequential load required for their implementation) or a simultaneous strategy (named Simultaneous Walking Test).
Subsequently, similar tasks were performed in reaching space, (by means Corsi Block tapping Test and a Modified Corsi Test for the sequential strategy and Simultaneous Paper Test for the simultaneous strategy).
The six tasks were submitted to factor analysis (Principal Axis Factoring). This analysis showed four factors that explaining the 51.3% of the total variance: Corsi Block tapping Test (.501); Simultaneous Paper and Walking Test (-.74 and -.51, respectively); Route A (-.38); Modified Corsi Test and the Route B (.72 and .67, respectively). This clustering demonstrates that - the sensorized platform, set up in the present study, allows to identify the different strategies performed to correctly solve visuo-spatial tasks in navigational space – the same strategies can be also used in reaching space according to the task demand
New protocol for dissociating visuospatial working memory ability in reaching space and in navigational space
No full textSeveral studies have demonstrated that the processing of visuospatial memory for locations in reaching space and in navigational space is supported by independent systems, and that the coding of visuospatial information depends on the modality of the presentation (i.e., sequential or simultaneous). However, these lines of evidence and the most common neuropsychological tests used by clinicians to investigate visuospatial memory have several limitations (e.g., they are unable to analyze all the subcomponents of this function and are not directly comparable). Therefore, we developed a new battery of tests that is able to investigate these subcomponents. We recruited 71 healthy subjects who underwent sequential and simultaneous navigational tests by using an innovative sensorized platform, as well as comparable paper tests to evaluate the same components in reaching space (Exp. 1). Consistent with the literature, the principal-component method of analysis used in this study demonstrated the presence of distinct memory for sequences in different portions of space, but no distinction was found for simultaneous presentation, suggesting that different modalities of eye gaze exploration are used when subjects have to perform different types of tasks. For this purpose, an infrared Tobii Eye-Tracking X50 system was used in both spatial conditions (Exp. 2), showing that a clear effect of the presentation modality was due to the specific strategy used by subjects to explore the stimuli in space. Given these findings, the neuropsychological battery established in the present study allows us to show basic differences in the normal coding of stimuli, which can explain the specific visuospatial deficits found in various neurological condition
Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via β,γ-unsaturated α-bromo-ketene/imine cycloaddition
No full textAn approach to 3-bromo-4-alkyl-6-aryl-5,6-dihydropyridin-2-ones and 3-bromo-5-ethyl-6-aryl-5,6-dihydropyridin-2-ones starting from β,γ-unsaturated α-bromoketenes and imines is reported. The presence of a bromine atom on the double bond allows performing aziridination or bromine displacement with an amine. The reaction gave fused bicyclic N-allyl-aziridines or 3-amino-substituted 5,6-dihydropyridin-2-ones, depending on the substituents on the six-membered ring
Zinc metal-promoted nucleophilic addition of azetidin-2-ones to aldehydes and nitriles
No full textThe reactivity of in situ generated organozinc reagents of 3-alkenyl-3-bromoazetidin-2-ones with aromatic and aliphatic aldehydes to give the corresponding alcohol derivatives has been studied. The effect of solvent and Lewis acids has been explored in order to improve the reaction yields. The application of this methodology to nitriles and acyl chlorides allowed the preparation of the corresponding keto derivatives. The products of these reactions could be of interest on account of their structural similarity with the already known cholesterol adsorption inhibitor
Practical synthesis of 3-bromo-5,6-dihydropyridin-2-ones via beta,gamma-unsaturated alpha-bromo-ketene/imine cycloaddition
No full textAn approach to 3-bromo-4-alkyl-6-aryl-5,6-dihydropyridin-2-ones and 3 -bromo-5-ethyl-6-aryl-5,6-dihydropyridin-2-ones starting from beta,gamma-unsaturated alpha-bromoketenes and imines is reported. The presence of a bromine atom on the double bond allows performing aziridination or bromine displacement with an amine. The reaction gave fused bicyclic N-allyl-aziridines or 3-amino-substituted 5,6-dihydropyridin-2-ones, depending on the substituents on the six-membered ring
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