1,721,097 research outputs found
Water at the surface: a useful tool for the evaluation of the degree of hydrophilicity or hydrophobicity of materials
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La chimica di superficie nella patogenicità originata dal particolato solido nell'ambiente di lavoro e nell'ambiente di vita
No full textSURFACE HETEROGENEITY ON HYDROPHILIC AND HYDROPHOBIC SILICAS: WATER AND ALCOHOLS AS PROBES FOR H-BONDING AND DISPERSION FORCES
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The oxidation of glutathione by cobalt/tungsten carbide contributes to hard metal-induced oxidative stress
No full textThe occupational exposure to cobalt/tungsten carbide (Co/WC) dusts causes asthma and interstitial fibrosis. The International Agency for Research on Cancer (IARC) recently classified the mixture Co/WC as probably carcinogenic to humans (group 2A). The mechanism of action of Co/WC involves particle driven generation of Reactive Oxygen Species (ROS) with consequent oxidative damage. The present study evaluates the reactivity of Co/WC dust toward glutathione (GSH) and cysteine (Cys). Co/WC oxidized thiols through a mechanism involving the generation of sulphur-centred radicals.Theresults areconsistent withtheoxidationtaking placeatsurfaceactivesites,apartofwhichisaccessible onlyto Cys S-H groups, but not to GSH ones. Such a reaction, with consequent irreversible depletion of antioxidant defenses of cells, will potentiate the oxidative stress caused by particle and cell generated ROS
In vivo and in vitro effect of specific surface area of manganese dioxide particulates on biological reactivity
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