162,205 research outputs found
Hypertext Transfer Protocol - HTTP/1.1
No full textThe Hypertext Transfer Protocol (HTTP) is an application-level protocol for distributed, collaborative, hypermedia information systems. It is a generic, stateless, object-oriented protocol which can be used for many tasks, such as name servers and distributed object management systems, through extension of its request methods. A feature of HTTP is the typing and negotiation of data representation, allowing systems to be built independently of the data being transferred. HTTP has been in use by the World-Wide Web global information initiative since 1990. This specification defines the protocol referred to as "HTTP/1.1". HTTP Working Group R. Fielding, UC Irvine INTERNET-DRAFT H. Frystyk, MIT/LCS <draft-ietf-http-v11-spec-04> T. Berners-Lee, MIT/LCS J. Gettys, DEC J. C. Mogul, DEC Expires October 3, 1996 June 3, Fielding, Frystyk, Berners-Lee, Gettys and Mogul [Page 3] Table of Contents HYPERTEXT TRANSFER PROTOCOL -- HTTP/1.1........................................... 1 Status of t..
[Report to Chief J. E. Curry, by an unknown author #1]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
[Report to Chief J. E. Curry, by an unknown author #2]
No full textReport to Chief J. E. Curry, by an unknown author. The report contains a list of officers who gave depositions to the United States Attorney
Adiponectin and left ventricular structure and function in healthy adults. J Clin Endocrinol Metab. 2008
No full textContext: Adiponectin inhibits protein synthesis in cardiac myocytes, thereby opposing the effect
of cardiac workload and trophic factors (in particular, insulin) on left ventricular (LV) mass and wall
thickness (WT).
Objective:Wetested whether adiponectinandits isoforms are related toLVmass,WT,andfunction
independently of metabolic factors.
Design: This was a cross-sectional study.
Subjects: The study included 77 healthy volunteers (42 men) aged 30–59 yr with normal LV structure
and function.
Main Outcome Measures: Insulin response and insulin sensitivity were assessed by oral glucose
tolerance test and euglycemic hyperinsulinemic clamp. LV mass, WT, stroke work, chamber function,
and myocardial longitudinal function were evaluated by standard Doppler echocardiography
and tissue Doppler imaging. Total and molecular isoforms of adiponectin were measured in
plasma.
Results: By multivariate analysis, independent factors affecting LV mass were sex, body mass index,
stroke work, and current smoking (R2 0.66). Independent correlates of LV WT were age, stroke
work, and plasma adiponectin (standardized r0.28, 0.41, and0.26, P at least0.005, R20.48).
LV longitudinal late diastolic velocity was independently related to age, body mass index, and
adiponectin (standardized r 0.20, 0.26, 0.33, P at least 0.05, R2 0.30). High-molecularweight
adiponectin (47% of total), but not lower molecular-weight isoforms, insulin sensitivity, or
other metabolic factors, was inversely and independently related to WT (standardized r0.27,
P 0.01) and myocardial longitudinal late diastolic velocity (standardized r 0.28, P 0.05).
Conclusion: In healthy subjects, circulating total and high-molecular-weight adiponectin are related
to LV WT and diastolic function, independently of age and metabolic factor
Changes in bioactive IGF-I and IGF-binding protein-1 during an oral glucose tolerance test in patients with liver cirrhosis
No full textLiver cirrhosis is characterized by reduced circulating IGF-I and this has been linked to an adverse clinical outcome. Therefore, we investigated the dynamic changes in circulating total, free, and bioactive IGF-I, IGF-binding protein (IGFBP)-1, IGFBP-2, and IGFBP-1-bound IGF-I (binary complex) during an oral glucose tolerance test (OGTT) in patients with liver cirrhosis
The effect of prolonged fasting on levels of growth hormone-binding protein and free growth hormone.
No full textOBJECTIVE: There are limited data on growth hormone-binding protein (GHBP) and free GH levels during the physiological challenge of a prolonged fast. Our aim was to explore the relationships between GHBP, free GH, total GH and non-esterified fatty acid (NEFA) levels during overnight and 24-hour fasts in healthy young adults. DESIGN: We measured nocturnal levels of GHBP at three time-points (22:00, 03:00, 08:00), NEFA every 60 min and ultra-filtered free GH and total GH at 15-minute intervals for 10 h (22:00-08:00) during an overnight and a 24-hour fast in 7 female and 4 male normal-weight subjects aged 24.8 years (range: 22.8-26.9) with BMI 22.5 kg/m² (range: 18-27). RESULTS: Spontaneous free and total GH levels were closely related during the overnight and 24-hour fasts (r=0.99, p<0.0001 and r=0.99, p<0.0001 respectively). 24 h of fasting led to an increase in levels of basal free GH (p=0.03), mean free GH (p=0.04), mean total GH (p=0.04) and NEFA (p<0.0001) whilst GHBP levels remained similar (p=0.8). Percentage free (over total) GH was similar during the overnight and prolonged fasts (p=0.3). There were no associations between levels of NEFA and free (r=0.24, p=0.5) or total GH (r=0.20, p=0.6). CONCLUSIONS: A 24-hour fast led to parallel increases in free and total GH levels whilst there was no discernable change in GHBP levels or the fraction of free GH. This suggests that GHBP plays a role in limiting variations of circulating free GH levels. NEFA levels increased during the prolonged fast but they were not correlated with free or total GH levels
Murder on the mountain: author talk with Peter J. Wosh
No full textAuthor talk by Peter J. Wosh on May 5th, 2022, on his book, "Murder on the Mountain: crime, passion, and punishment in gilded age New Jersey.
Mr. Melvin J. Collier, RWWL AUC, June 2011
No full textThis video is a conversation with Mr. Melvin J. Collier. Mr. Collier talks about his book, "From Mississippi to Africa: A Journey of Discovery". Daniel Le, AUC Woodruff Library, is the interviewer
Adiponectin isoforms, insulin resistance and liver histology in nonalcoholic fatty liver disease
No full textBackground: Nonalcoholic fatty liver disease is associated with insulin resistance and low adiponectin levels. Adiponectin circulates as high-, medium- and low-molecular weight complexes, possibly exerting different insulin-sensitising effects.
Aim: We investigated adiponectin isoforms in nonalcoholic fatty liver disease in relation to liver disease severity and insulin resistance.
Patients and methods: Total adiponectin and isoform distribution were measured in 54 biopsy-proven, non-diabetic nonalcoholic fatty liver disease subjects, divided according to their fasting and 120-min glucose levels during an oral glucose tolerance test, as well as in 44 matched healthy controls. Insulin resistance/sensitivity was estimated in nonalcoholic fatty liver disease by the homeostasis model assessment and the oral glucose insulin sensitivity during oral glucose tolerance test. Total adiponectin and adiponectin isoforms were determined by in-house assays.
Results: Total adiponectin was reduced in nonalcoholic fatty liver disease (5.32±1.85 mg/L vs. 9.11±3.46 mg/L), with a relative abundance of high-molecular weight (34% vs. 47%) and low-molecular weight adiponectin (16% vs. 19%), coupled with dearth of medium-molecular weight adiponectin (50% vs. 34%) (P < 0.001 for all comparisons). In nonalcoholic fatty liver disease, adiponectin did not differ in relation to homeostasis model assessment, but levels were remarkably higher in relation to oral glucose insulin sensitivity-determined insulin sensitivity. However, the distribution of isoforms did not vary with disease severity, BMI class, glucose regulation or insulin resistance.
Conclusion: Adiponectin levels are reduced in nonalcoholic fatty liver disease, without any significant contribution of isoform distribution to progressive liver disease
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