170,473 research outputs found
A five-day treatment of tumor-induced hypercalcemia by intravenous amino-hexane (AHBP) or aminobutane (ABBP) bisphosphonate
No full textTreatment of advanced breast cancer with folinic acid, 5-fluorouracil and mitomycin C.
No full textSecond National Congress of Medical Oncology, Oct 28-31, 2000- Genoa, Ital
Extramammary invasive Paget’s disease and apocrine angiomatous hamartoma: an unusual association
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Circulating free DNA (cfDNA) as biomarker of taxane resistance in metastatic castration-resistant prostate cancer (mCRPC)
No full textIntroduction Docetaxel (D) and cabazitaxel (C) are the standard chemotherapy for mCRPC. No biomarker predictive of resistance to D or C has been approved yet. Based on preliminary clinical data, we aimed to assess the association between ABCB1 amplification (ABCB1 amp) and primary resistance (RES) to D or C for mCRPC, using cfDNA. Methods A cohort (A) of 136 patients (pts) with at least 1 plasma sample drawn and stored within 12 months prior to starting D for mCRPC (2002-2014) and a cohort (B) of 42 pts with at least 1 plasma sample drawn and stored within 12 months prior to starting C for mCRPC (2010-2016) were identified from the Dana-Farber Cancer Institute IRB approved database. Whole genome sequencing (WGS) at 0.1x coverage, termed ultra-low pass WGS (ULP-WGS), was performed on the cfDNA extracted from the selected samples (1000μL/subject) and sequencing data were run through ichorCNA, a probabilistic model that allows to detect cases with sufficient tumor DNA content (>7%) and accurately identify copy number alterations (CNAs) including ABCB1 amp. Primary endpoint was assessing the association between ABCB1 amp and RES to D or C. Secondary endpoint was evaluating associations between any other CNAs with ≥10% prevalence and RES to D or C. RES was defined as the absence of a response, defined as PSA50 decline or radiologic response according to RECIST criteria version 1.1, within 16 weeks from treatment start. Odds ratio (OR) was used to compare odds of RES to D or C for pts with ABCB1 or exploratory CNAs and P-values were calculated by Fisher’s exact test or Monte Carlo simulation. Results Of the selected 178 pts, 66 had sufficient tumor purity: 45 pts in cohort A and 21 in cohort B. The rates of men with ≥4 prior therapy lines were 22.2% in cohort A and 71.4% in cohort B. No significant association was noted between ABCB1 amp and RES to D (P=0.7123; OR=1.600) or C (P=1.000; OR=1.0606). RES was observed in 26 pts (57.8%) of cohort A and 18 (85.7%) of cohort B. ABCB1 amp was observed in 9 pts (20%; 95% CI, 9.6-34.6) in group A and 6 of them (66%) had RES to D. ABCB1 amp rate among D-resistant men was 23.1% (95% CI, 9.0-43.7). In group B, 2 pts (9.5%; 95% CI, 1.2-30.4) had ABCB1 amp and both of them had RES to C. ABCB1 rate among C-resistant pts was 11.1% (95% CI, 1.4-34.7). No significant association was found between exploratory biomarkers and RES to D or C. Conclusion In this study, ABCB1 amp does not predict for RES to D or C for pts with mCRPC. Future studies including ABCB1 amp in a suite of putative biomarkers and larger samples may aid drawing definitive conclusions
Local actors, stakeholders and visitors for the tourism management of a cultural city: the case study of the Historical Centre of Florence
No full textPhenolics and Mineral Elements Composition in Underutilized Apple Varieties
No full text(1) Background: The aim of this research is to study the importance of improving knowledge of old variety apples in terms of phytochemicals, antioxidant capacity and mineral elements. (2) Methods: Fifteen phenolic compounds (UHPLC-MS/MS techniques), eight mineral elements (Ca, K, Cu, Mn, Fe, Zn, Na and Mg), antioxidant capacity (DPPH%) and vitamin C content in four ancient apple varieties of Tuscany (‘Mora’, ‘Nesta’, ‘Panaia’ and ‘Ruggina’), with the ‘Golden Delicious’ cultivar as reference, were analyzed. (3) Results: Ancient cultivars exhibited a superior antioxidant capacity compared to commercial cultivars. ECTC and CGA were the polyphenols that mostly characterized the ancient apples. The contents of the elements of concern, Zn and Mn, were higher in the ancient cultivars ‘Panaia’ and ‘Ruggina’, while Na showed significant low concentration in ‘Nesta’, ‘Panaia’ and ‘Ruggina’ compared to ‘Golden Delicious’. The vitamin C content also indicated that ‘Mora’, ‘Panaia’ and ‘Ruggina’ old variety had an AsA content around 10 times higher than the ‘Golden Delicious’ apple. (4) Conclusions: Underutilized varieties could be an excellent source of bioactive phenolic phytochemicals, mineral nutrients and vitamins that may offer special nutraceutical benefits compared to other fruits
L’intervento pubblico nel contrasto alla ludopatia: brevi cenni
No full textIl lavoro si prefigge lo scopo di analizzare brevemente gli strumenti di contrasto al fenomeno della ludopatia predisposti dal legislatore italiano
A New Sampling Strategy for Enhancing Forest Monitoring Leveraging Remote Sensing Data
No full textNowadays, monitoring forests and supporting decision-makers with reliable data on biomass are more important than ever. Such data are commonly collected at the national level using spatial sample surveys. However, due to the high costs of surveying and processing, sampling intensity is often low, and the estimates’ precision may be unsatisfactory. We propose a new sampling strategy for forest inventories that takes advantage of increasingly accurate and accessible remotely sensed data made available by technological advancements. Our approach includes an assessment of the potential utility of incorporating remote sensing data into the sampling design and incorporates them only if deemed beneficial. This is achieved through a two-step sampling process. Initially, a well-spread smaller sample is drawn to examine the nature and strength of the relationship between the auxiliary and response variables. Then, depending on the observed relationship, the spatial sampling design for selecting the remainder of the sample is adjusted to (possibly) incorporate the auxiliary information. Our proposal’s performance is evaluated through Monte Carlo experiments based on simulated datasets and real-world data that motivated our analysis. Specifically, we focus on estimating the storage of terrestrial carbon in biomass and soil using satellite remote sensing optical data as auxiliary information. Supplementary materials accompanying this paper appear online
Circulating levels of immunoreactive parathyroid hormone (PTH) and calcitonin (CT) In bronchogenic carcinoma
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