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    β-Lactamase induction antagonizes β-lactam susceptibilities in Citrobacter diversus and Enterobacter cloacae clinical isolates

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    Inducible β-lactamases were obtained after exposure to several β-lactams in clinical isolates of Enterobacter cloacae and Citrobacter diversus. Enzyme production was related to the inducer and medium composition. β-lactamase is able to inactivate only labile compounds, thus generating minimum inhibitory concentrations higher than in the absence of the inducer; imipenem susceptibilities usually were not changed
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