1,720,980 research outputs found
Regulatory role of bradykinin in the coronaric and cerebral circulations and in systemic hemodynamics
No full textRegulatory role of bradykinin in the coronary and cerebral circulations and in systemic hemodynamics
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Anti-inflammatory properties of drugs from Saffron Crocus
No full textThe medicinal uses of saffron (Crocus sativus Linnaeus) have a long history beginning in Asian countries since the Late Bronze Age. Recent studies have validated its potential to lower the risk of several diseases. Some metabolites derived from saffron stigmas exert numerous therapeutic effects due to hypolipidemic, antitussive, antioxidant, antidiabetic activities and many others. Water and ethanol extracts of Crocus sativus L. are cardioprotective and counteract neurodegenerative disorders. Many of these medicinal properties of saffron can be attributed to a number of its compounds such as crocetin, crocins and other substances having strong antioxidant and radical scavenger properties against a variety of radical oxygen species and pro-inflammatory cytokines. Botany, worldwide spreading of cultivars, biochemical pathways, active constituents and chemical detection methods are reviewed. Therapeutic uses of saffron principles with particular regard to those exhibiting antioxidant and thus anti-inflammatory features are discussed. To date, very few adverse health effects of saffron have been demonstrated. At high doses (more than 5 g/die day), it should be avoided in pregnancy owing to its uterine stimulation activity
Investigations about ancient DNA require both genomics and HPLC analysis to guarantee reliable data
No full textAgreement between evidences of hepatitis from historical documents and genetic susceptibility to primary biliary cirrosis about some bone relics from Pescina, L'Aquila, Italy, XI century AD
No full textImmunogenetics and HPLC analyses contribute to understanding the etiopathology of rheumatoid arthritis through studies on ancient human remains
No full textFurther genomic testing and histological examinations confirm the diagnosis of rheumatoid arthritis in an Italian mummy from the 16th century
No full textThe ancient genomic DNA (anDNA) and analysis of genetic risk factors related to autoimmune rheumatic disease
No full textRP-HPLC method with fluorescence detection for amino acids <scp>D</scp> /<scp>L</scp> ratio determination in fossil bones as a marker of DNA preservation
No full textOnly a small proportion of old specimens contain DNA that can be amplified by PCR. Therefore, rapid screening methods are crucial to identify the large fraction of samples that are so badly preserved that there is no need to attempt DNA extraction. In particular, the extent of racemization of some amino acids has proved to be a very useful proxy for DNA preservation. In this study, a rigorous method for the determination of the D/L ratio for aspartic acid and alanine by RP-HPLC with fluorescence detection was developed with the aim to obtain a fast and cheap procedure for both sample preparation and amino acids analysis, without compromising precision and accuracy
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