1,721,051 research outputs found
Conflicting results on peripheral adrenoceptor function in hypotension of hemodialyzed patients.
No full textComment on Thrombocyte alpha-2-adrenoceptors and hypotension in hemodialyzed patients
Cross-talk between the complement system and endothelial cells in physiologic conditions and in vascular diseases.
No full textAbstract
The endothelial layer represents a continuous physical barrier that controls coagulation and allows selective passage of soluble molecules and circulating cells across the vessel wall into the tissue. The functional activity of the endothelial cells may be influenced by their interaction with components of the complement system. In this review we shall discuss the complex interplay that can be established between the endothelium and complement proteins or activation products. Endothelial cells may also secrete several complement components which contribute to the circulating pool. This process can be regulated by cytokines and other pro-inflammatory stimuli. In addition, complement activation products stimulate endothelial cells to acquire a pro-inflammatory and pro-coagulant status. Expression of regulatory molecules on the cell surface provides protection against an undesired attack by complement activation products. Unrestricted complement activation under pathological conditions may lead to structural and functional changes of the endothelium resulting in vascular disease
Measurement of the efficacy of antihypertensive drugs in experimental animals.
No full textTwo different techniques of measurement of blood pressure, i.e. direct measurement of carotideal arterial pressure in conscious unrestrained animals or sfigmomanometric caudal determination, have been employed for assessing the antihypertensive effects of two reference drugs, clonidine and guanfacine.
The examination of carotideal blood pressure proved to be particularly useful for studying the acute effects of drug treatment and rvealed an early hypertensive action of guanfacine. The indirect sfigmomanometric determination of blood pressure appeared best suited for examining the chronic effects of drug treatment
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