1,717 research outputs found
From the Editor-in-Chief: Changes to Enhance the Author Experience
No full textJMBE Editor-in-Chief, Dr. Samantha Elliott, thanks past volunteers for their efforts and discusses several new author enhancements related to the recently expanded scope, including video tutorials, a self-assessment tool, and a thematic issue
Nephrite Jade in West Pakistan
No full textTwo pebbles of the nephrite variety of jade were found by the author in 1955 in the river bed of the Teri Toi in Kohat District of former North-West Frontier Province of West Pakistan; the positive identification of the compositions of the pebbles was, however, not made until February, 1962. This appears to be the first authenticated record of either of the true jade minerals (nephrite or jadeite) in Pakistan or India, and the discovery is of significance in relation to the unsolved problem of the origin of the raw material of Indian carved jade.</jats:p
Project Jade Weser Port: A feasibility study
No full textTogether with the amount of transported containers, the size of the container vessels increases. With the size of the ships their draught also becomes larger. At the moment Germany does not have a harbour, suitable to receive these large container vessels. The idea has risen to design and construct a new deep-water port. The authorities took some time contemplating where this port has to be built. Wilhelmshaven versus Cuxhaven was the dilemma. Finally, in March 2001, a temporary decision was made: a new deepwater port is to be built near Wilhelmshaven. One of the strongest points of the area near Wilhemshaven is the great possibilities for future expansion. The scope of this report is limited to the design of a deepwater port near the Wilhelmshaven: the Jade Weser Port. The Jade estuary is very suitable as a harbour, having a natural deep-sea channel and being situated close to open sea. Besides that, a large area is available for the terminal and the infrastructure on land has good possibilities for expansion. For a project, as great as the Jade Weser Port, several studies have to be done. The economic situation is one of the first studies that should be done. The Jade Weser Port studies into this subject are not widely available. This leads to the first question: Is the Jade Weser Port economically/financial feasible? Ballast Nedam has also done research into the future Jade Weser Port. Because of this research the design of the quay in the feasibility study gave reason to Ballast Nedam Dredging for some questions. The quay wall is not protected from waves and currents and there are no breakwaters to protect the berths. The quay lies parallel to the approach channel, just a couple of hundred meters away from it. This situation has led to the following question: Does the unprotected quay lead to any nautical or operational difficulties? If so, is there not a better option for the layout of the quay? The objective of this thesis study is to answer the questions that are outlined in the problem description above. This is done in the following studies: Financial/economical study Nautical/hydraulic study This report is a feasibility study for the Jade Weser Port. This feasibility study consists of five parts. First a study on the location and environmental aspects of the Jade Weser Port has been done, secondly a financial study has been done and after that the preliminary design aspects of the port are described. At last the currents, waves and navigation in and around the port are analysed. The feasibility study is concluded with the conclusions and recommendations for the new port. The results for the port can be presented by the following remarks: The financial feasibility study of the port does not show very encouraging results, although a definitive negative advice can not be given. The nautical feasibility study of the port does show promising results. The circumstances can be rough, but this will not result in much downtime.Hydraulic EngineeringCivil Engineering and Geoscience
Death Writes: Microbursts & The Clearing: a discussion on text, subject and craft with Elizabeth Reeder and Amanda Thomson - collaborators on microbursts and with Samantha Clark author of The Clearing
No full textDeath Writes is part of the University of Glasgow's interdisciplinary Arts-Lab, Reading and Writing Death and Dying.
Elizabeth Reeder, Amanda Thomson (collaborators on Microbursts) and Samantha Clark (author of The Clearing) will read and talk about their books and the writing, design and editorial processes they underwent. Both books deal with the intense time of being within parental illness, and consider experiences of illness, mental health, parental death, and various types of grief in ways that weave through and utilise artistic and multi-modal processes
Laboratory Exercises for Weather and Climate: Open Education Resource
No full textOER textbook created for PHS 111 by Samantha Langton, PhD.NASUNY DutchessPhysical Sciences, Engineering & TechnologyN/
The role of the periplasmic Cu metallochaperone AccA in metalating the Cu-dependent nitrite reductase AniA in Neisseria gonorrhoea
No full textNeisseria gonorrhoeae (the gonococcus) respires nitrite (NO2-). This process requires the nitrite reductase, AniA, which contains T1- and T2Cu in its active sites. We have characterised AccA, a PCuAC homologue with an extended His- and Met-rich C-terminal domain, as a likely periplasmic Cu- binding metallochaperone that metalates AniA.
In this study, biochemical examination of purified AccA and site-directed variants confirms that it binds one Cu(I) atom with femtomolar affinity in the conserved 2 His, 2 Met binding site. The C-terminal domain binds Cu(II) with picomolar affinity, although precise ligands remain unknown. Gonococcal strains lacking AccA or any conserved His and Met residue in AccA fail to grow and reduce NO2-. This phenotype is reversed when Cu(II) salts are supplemented in the growth medium. These results suggest that, in the absence of AccA, AniA is expressed as an apo-enzyme, but is re-metalated if the periplasmic buffered Cu pool increases. Interestingly, gonococcal strains lacking the C-terminal domain of AccA show reduced growth and NO2- consumption only in the presence of the Cu(I) chelator BCS, suggesting a role during Cu starvation.
Cu-transfer experiments using purified proteins confirmed AccA metalates both Cu sites in AniA with metal coordinated by both the Cu primary and C-terminal Cu binding sites. However, the C-terminal tail was required for metalation of the T2-site. AniA is expressed as a monomer and Cu binding induces protein trimerisation. This may offer an alternative role of why AccA is required to metalate AniA in vitro.
This work raises questions regarding the thermodynamics and kinetics of how metalloproteins acquire Cu from the buffered cellular pool via metallochaperones
198 - Samantha Mosier
No full textIncludes bibliographical references.Using pre-commercial thinnings in pine plantations has the potential to deliver sustainable biofuels. However, the removal of biomass from these plantations could reduce C inputs belowground and overall C storage. This study analyzes soil C and N stocks to estimate stock changes, as a function of soil type and different management systems. Soil cores were taken from 12 different southern pine plantations, representing 4 different soil types. Each site had 2 silvicultural regimes across 3 levels of pre-commercial thinning. Soils were separated into meaningful fractions to understand how much soil organic matter is bioavailable and how much is stabilized
Interpersonal psychotherapy for depression in Parkinson's disease
No full textStudies have shown depression to affect up to 50% of individuals diagnosed with Parkinson’s disease (PD) and to have a negative impact on the progression of the illness. However, there is a dearth of research on psychosocial interventions for the treatment of depression in this population. To date, the utility of interpersonal psychotherapy (IPT), an evidence-based treatment for depression with demonstrated effectiveness in medical populations, has not been examined for this population. This case series was conducted to examine the feasibility and effectiveness of interpersonal psychotherapy (IPT) for depression in individuals with Parkinson’s disease (PD). Three PD patients with Major Depressive Disorder or Dysthymia participated in the study along with a caregiver. Patients received 6 to 15 sessions of IPT primarily focused on resolving the interpersonal problem area of role transition. Caregivers attended 1 to 2 sessions which provided psychoeducation and garnered necessary supports to help patients accomplish their treatment goals. Two of the patients experienced improvement in depressive symptoms, particularly in mood, interest and motivation in activities, with gains maintained at 1-month follow-up. There was some evidence of reductions in caregiver burden as a result of the intervention, though no significant change in caregiver depressive symptoms was noted. Results of this case series suggest that IPT may be a feasible and effective option for the treatment of PD depression. Larger, controlled trials are needed to replicate these results and to further evaluate the efficacy of this intervention.Psy. D.Includes bibliographical referencesby Jade T. Rubin
Elaborative feedback: Engaging reward and task-relevant brain regions promotes learning in pseudoword reading aloud
No full textAlthough much is known about the cognitive and neural basis of establishing letter-sound mappings in learning word forms, relatively little is known about what makes for the most effective feedback during this process. We sought to determine the neural basis by which elaborative feedback (EF), which contains both reward-related and content-specific information, may be more helpful than feedback containing only one kind of information (simple positive feedback, PF) or the other (content feedback, CF) in learning orthography-phonology (spelling-sound) mappings for novel letter strings. Compared to CF, EF activated the ven- tromedial prefrontal cortex, implicated in reward processing. Compared to PF, EF activated the posterior middle temporal, superior temporal, and supramarginal gyri—regions implicated in orthography-phonology conversion. In the same comparison, EF also activated the left fusiform gyrus/visual word form area—implicated in orthographic processing. Also EF, but not CF or PF, modulated activity in the caudate nucleus. In a postscan questionnaire, EF and PF were rated as more pleasant than CF, suggesting that modulation of the caudate for EF may be due to the coupling of reward and skill content. These findings suggest the enhanced effectiveness of EF may be due to concurrent activation of reward-related and task-relevant brain regions.Peer reviewe
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