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Left ventricular diastolic function in liver cirrhosis
Background: Left ventricular systolic abnormalities have been reported in liver cirrhosis (LC). Diastolic function in cirrhotics, on the contrary, does not seem to have been studied so far. Methods: Diastolic function was evaluated in 42 cirrhotic patients and in 16 controls by means of Doppler echocardiography. Results: Compared with the controls, cirrhotics had increased left ventricular end-diastolic and left atrial volume, stroke volume, late diastolic flow velocity (peak A) (71 ± 17 cm/sec versus 56 ± 18; p < 0.01), time from onset of mitral inflow to the early peak (time E) (86 ± 11 msec versus 72 ± 14; p < 0.003), and deceleration time (DT) (194 ± 40 msec versus 159 ± 27; p < 0.001) and decreased ratio of peak E to peak A filling velocities (1.02 ± 0.35 versus 1.22 ± 0.25; p < 0.02). Patients with tense ascites had a higher E/A ratio (p < 0.03) and a shorter DT (p < 0.03) than patients with mild or no ascites. Conclusions: The impaired left ventricular relaxation in the presence of high stroke volume suggests a myocardial involvement in LC. The pseudonormalization of the E/A ratio and DT in patients with tense ascites could reflect loading conditions masking the relaxation abnormality
Long-term effects of beta-adrenergic blockade with nadolol on hepatic and renal haemodynamics and function in cirrhotics
Effect of somatostatin on splanchnic hemodynamics in patients with liver cirrhosis and portal hypertension.
Evaluation angiografique semiquantitative de la perfusion portale chez les cirrhotiques: relations avec le debit plasmatique hepatiqhe.[lettre]
Alterazioni circolatorie splancniche e periferiche nella cirosi: studio mediante eco-color-doppler. Risultati a lungo termine del Centro Trapianti di Padova.
Semiquantitative angiographic assessment of portal perfusion in cirrhotic patients: relation to hepatic plasma flow.
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