1,721,005 research outputs found
A direct access to a potential LTB4-antagonist, SM-9064, via disilyl derivatives
No full textThe synthesis of SM-9064, a potential LTB4 antagonist, which is effective in some types of inflammation, has been easily achieved in a few steps by electrophilic substitution reactions between (1E,3E,5E)-1,6-bis(trimethylsilyl)-1,3,5-hexatriene and acyl chlorides in the presence of aluminum trichloride, followed by reduction reaction and formation of pyrrolidine derivative
An easy access to 4-(1,2,3-triazolylalkyl)-1,2,3-triazole-fused dihydroisoquinolines and dihydroisoindoles
No full textA convenient synthesis of 4-(1,2,3-triazolylalkyl)-1,2,3-triazole fused dihydroisoquinolines and
dihydroisoindoles is reported, starting from easily available (2-iodoaryl)alkyl azides and terminal
alkynols. The procedure is based upon transition-metal catalyzed coupling reactions followed by iterative
cycloaddition reactions
C-Alkylation and Michael Addition Involving the Polymer - Supported Carbanion from Methyl Nitroacetate
No full textCONJUGATED POLYENE SYNTHESIS VIA DISILYL DERIVATIVES - A DIRECT ACCESS TO OSTOPANIC ACID, A PLANT ANTICANCER AGENT, AND TO (6E)-LTB3 LEUKOTRIENE
No full textAn easy approach to 1-silylated ketones and asymmetrical 1,6- and 1,8-dicarbonyl compounds
No full textA variety of 1-silylated ketones and asymmetrical 1,6- and 1,8-dicarbonyl compounds are synthesized with 70-85% yields by means of Pd-catalysed selective hydrogenation reactions of the corresponding unsaturated conjugated products, readily available by a previously reported procedure
A New Straightforward and General Approach to Dienamide Natural Products
No full textA new synthetic approach to various conjugated (EE) dienamides has been developed, starting from an easily accessible bifunctional dienyl compound and based upon a double selective electrophilic substitution, followed by coupling reactions
New Synthesis of Leukotriene B3 Methyl Ester from bis(Trimethylsilyl) Unsaturated Derivatives
No full textA new synthesis of leukotriene B-3 methyl ester is reported, starting from bis(trimethylsilyl) unsaturated derivatives as building blocks for the triene moiety of the leukotriene. The two stereogenic centers have been generated by enantioselective chemical reduction of two acetylenic ketones with both R-or S-Alpine Borane (R). The three conjugated double bonds system of the leukotriene has been assembled by Miyaura-Suzuki cross-coupling reaction. (C) 1998 Elsevier Science Ltd. All rights reserved
A Straightforward Approach to Unsaturated Carboxylic Acid Derivatives Strarting from Bis-Silylated Precursors
No full text
ONE-STEP SYNTHESIS OF 1,N-DICARBONYL COMPOUNDS FROM CARBOXYLIC-ACID DERIVATIVES AND DI-GRIGNARD REAGENTS IN THE PRESENCE OF TRANSITION-METAL CATALYSTS
No full textThe transition metal catalyzed cross-coupling reaction of alkane di-Grignard reagents with carboxylic acid derivatives provides a convenient one-step synthesis of symmetrical 1, n-diketones (n greater-than-or-equal-to 8) and long-chain dicaboxylic thiol esters
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