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Considerationi predicabili sopra gli evanglii dellla quaresma et altre Feste. Con Due tabole;, Degli Argomenti.. E Cose piú notabili
No full textMarca tip. na portSign.: a-b\p4\s, c\p5\s, A-Z\p4\s, 2A-2Z\p4\s, 3A-3Z\p4\s, 4A-4N\p4\s, 4O\p6\s, a-m\p4\sTexto a liña tirada, con apostilas marxinais e reclamosFront. calc.: "In Umbratua vivemus
Considerationi predicabili sopra gli evangelii della quaresma et altre feste : con due tavole : Degli argomenti, e Cose più notabili
No full textSign.: a\p6\s, A-3Z\p4\s. 4a-4F\p4s, a-l\p4\
Clotting Activation and Hyperfibrinolysis in Cirrhosis: Implication for Bleeding and Thrombosis
No full textHyperfibrinolysis may be detected in patients with cirrhosis, particularly in case of severe liver failure. Hyperfibrinolysis is usually associated with prolonged global tests of clotting activation, which are then dependent on impaired synthesis of clotting factors by liver cells. The term "coagulopathy" has therefore been coined to indicate the existence of hyperfibrinolysis and blood hypocoagulation in cirrhosis, and, for a long time, these changes have been believed to facilitate bleeding. However, apart from gastrointestinal bleeding, which is related prevalently to hemodynamic factors in the portal circulation, spontaneous bleeding is less frequent than would be expected by the abnormality of laboratory tests. This apparent paradox may be explained by studies questioning the term "coagulopathy," instead documenting a hypercoagulation state in portal as well as in peripheral circulation of cirrhotic patients. The support of these findings by more recent data allows a redefinition of the overall clotting picture, in particular hyperfibrinolysis, in cirrhosis. Thus, this review analyzes prevalence and clinical impact of hyperfibrinolysis in cirrhosis, focusing in particular on whether it is primary or secondary to clotting activation. Furthermore, we focused such changes in the context of more recent data showing an association between cirrhosis and thrombosi
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Hyperfibrinolysis in liver disease. 2009 Feb;13(1):21-31.
No full textThe incidence of hyperfibrinolysis in patients with cirrhosis is still debated. The reasons for this uncertainty probably lie in the lack of appropriate laboratory tests for its evaluation. There is a relative consensus, however, that hyperfibrinolysis can complicate the clinical course of liver cirrhosis, especially in cases of moderate to severe liver failure. Hyperfibrinolysis correlates positively with the severity of underlying liver disease, and low-grade systemic fibrinolysis is found in 30% to 46% of patients who have end-stage liver disease. Accelerated intravascular coagulation with secondary hyperfibrinolysis has been reported in patients who have liver failure. Hyperfibrinolysis may delay primary hemostasis, thereby aggravating variceal bleeding and facilitating recurrenc
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