1,721,151 research outputs found
Impiego di una crema antiossidante nel trattamento della dermatite seborroica dell’adulto
No full textNew insights on scleromyxedema
No full textScleromyxedema is a rare fibromucinous disorders, with several clinical and pathological overlaps with scleroderma and scleredema. Etiopathogenesis remains uncovered, and no explanation has been provided either for the origin of mucin deposition or for the paraprotein role. The disease does not show gender predilection and affects mainly middle-age adults. The course is unpredictable, and prognosis remains guarded for renal, cardiac, and neurologic complications, especially in the setting of dermato-neuro syndrome. A valuable recent progress is the consensus definition of diagnostic criteria and lines of treatment, which hold the promise to improve the early recognition and management of this rare condition worldwide. High-dose intravenous immunoglobulin has been suggested as the first-line treatment either alone or associated with systemic steroids and/or thalidomide. In very recalcitrant cases, adjunctive bortezomib and/or autologous stem cell transplant might be considered. Melphalan treatment was associated with very toxic side effects and actually is no longer recommended
Glomeruloid reactive angioendotheliomatosis in a woman with systemic lupus erythematosus and antiphospholipid syndrome mimicking reticular erythematous mucinosis
Full text linkThe umbrella term ‘‘cutaneous reactive angioma- toses’’ was introduced in 2003 to include uncommon angioproliferative (capillary) cutaneous conditions, which present with variable clinical features and involve patients with a variety of underlying systemic conditions.1 Histologically, these disorders are char- acterized by different patterns of intravascular or extravascular lobular or diffuse hyperplasia of endo- thelial cells, pericytes, and, sometimes, histiocytes, mostly throughout the dermis.1 The first condition to be described was reactive angioendotheliomatosis (RAE), which is usually associated with prothrom- botic conditions.1 We report a case of RAE in its rare glomeruloid variant, occurring in a woman with systemic lupus erythematosus (SLE) and antiphos- pholipid syndrome (APS), which is notable because it mimics reticular erythematous mucinosis (REM)
Extensive and recalcitrant verrucae vulgares of the great toe treated with imiquimod 5% cream
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