1,720,974 research outputs found
Nab-Paclitaxel induced cystoid macular edema: clinical experience with intravitreal implant of dexamethasone vs topical dorzolamide
No full textiniezione intravitreale di triamcinolone acetonide nel trattamento dell'edema maculare diabetico
No full textcon questo studio si è inteso valutare le potenzialità terapeutiche, l'efficacia e la tollerabilità del triamcinolone acetonide somministrato per via intravitreale nella dose di 0.05ml nella cura dell'edema maculare retinico. sono stati selezionati 11 pazienti dei quali è stato valutato l'eventuale miglioramento della capacità visiva, nonchè le variazioni dello spessore retinico (quantificato con OCT). in 9 pazienti su 11 si è riscontrato un miglioramento dell'acuità visiva, con mantenimento degli indici perimetrici senza variazioni significative della pressione intraoculare
Indagine socio-oftalmologica sulla popolazione scolare e prescolare in una comunità montana (Pescasseroli).
No full textGli AA valutano i risultati sulla prevenzione oftalmologica in bambini in età prescolare e scolare nella Cominità Montana del comune di Pescasseroli sottoposti a visita oculistica
Central 10° automated perimetry and contrast sensitivity in patients suffering from exudative macilar degeneration before and after treatment with photodynamic therapy
No full textPurpose: Photodynamic therapy (PDT) has recently proved to be very effective in the management of exudative macular degeneration. The aim of this study was short–term evaluation (three and ten weeks) of visual function in patients with exudative macular degeneration subjected to PDT. Methods: 30 patients (12 male and 18 female) with an age range from 56 to 81 years (average age 73.4 +–9.86) were selected and enrolled in the study. The same day of PDT (time 0) the selected patients underwent white on white 10° computerized visual field (Humphrey 750 10/2 full threshold ) and contrast sensitivity examination at spatial frequencies of 2 C/°, 4 C/°, 6C/°, 12 C/° and 18 C/° (CCON (c) 1993–95 TwoDocs, Inc. Version 95). These tests were subsequently repeated after three and ten weeks from PDT. Fluorescein angiography was also carried out at time 0 and repeated after 10 weeks from PDT. Results: After ten weeks from PDT treatment, the mean contrast sensitivity was 60.16 ±17.68, whereas before therapy it was 44.80 ±12.60, with a significant difference of 15.36 dB (p<0.01) and a significance difference the medium–low spatial frequencies (p<0.05) . Mean Defect (MD) and Pattern Standard Deviation (PSD) and the value of the foveal threshold were considered in the visual field . MD and PSD before and after treatment were statistically significant in the tests carried out 3 weeks after PDT while in following test
Twelve-month results of a single or multiple dexamethasone intravitreal implant for macular edema following uncomplicated phacoemulsification
Full text linkThe clinical efficacy of one or two intravitreal injections of a continued deliverance dexamethasone 700 μg implant in ten patients with persistent macular edema following uncomplicated phacoemulsification was evaluated. Complete ophthalmological examination and spectral domain optical coherence tomography were carried out. Follow-up was at day 7 and months 1, 2, 4, 6, 8, and 12. At baseline mean best corrected visual acuity was 62 Early Treatment Diabetic Retinopathy Study Chart letters, which showed statistically significant improvement at each follow-up, except at month 6, to reach 79 letters at month 12 (P = 0.018). Prior to treatment mean central foveal thickness was 622 μm, which showed statistically significant improvement at each follow-up to reach a mean value of 282 μm (P = 0.012) at month 12. Five patients received a second dexamethasone implant at month 7. Two patients were excluded from the study at months 4 and 8. Intraocular pressure remained stable during the study period with the exception of mild increase in two patients requiring topical therapy. In conclusion there was statistically significant improvement of best corrected visual acuity and mean central foveal thickness with one or two intravitreal dexamethasone implants over 12 months
Anatomical And Functional Effects Of Intravitreal Corticosteroids On Patients Affected By Diabetic Macular Edema
No full textValutazione mediante metodiche psicofisiche di pazienti affetti da degenerazione maculare senile prima e dopo terapia fotodinamica
No full textObiettivi: studiare l’influenza della terapia fotodinamica con verte porfina mediante metodiche psicofisiche (sensibilità al contrasto ed esame del campo visivo computerizzato) in pazienti affetti da degenerazione maculare essudativa prevalentemente classica. Procedure di base: studio comparativo osservazionale eseguito su trenta occhi con membrane coroideali neovascolari secondarie a degenerazione maculare senile da trattare con terapia fotodinamica con verte porfina. I pazienti sono stati sottoposti ad esame dell’acuità visiva , esame fluorangiografico con fluoresceina, esame della sensibilità al contrasto ed esame del campo visivo computerizzato dei 10° centrali, sia prima della PDT sia a distanza di tre e dieci settimane dalla stessa. Risultati: dopo il trattamento con terapia fotodinamica si è ottenuto un aumento generale dei valori di contrasto,, in particolare dei valori alle frequenze spaziali medio-basse. A tre settimane dalla PDT tutti gli indici perimetrici considerati sonjo migliorati con una differenza statisticamente significativa, che non è stata però confermata a dieci settimane dal trattamento. Si è inoltre riscontrato che gli occhi nei quali la membrana neovascolare, in seguito al trattamento con PDT, è risultata ridotta nella dimensioni, risultano essere gli occhi con un miglioramento significativo dei valori dei test psicofisici, a dieci settimane dalla terapia, oltre ad aver mantenuto un’acuità visiva stabile nel tempo, al contrario degli occhi nei quali le membrane neovascolari sono rimaste invariate o ridotte nelle dimensioni. Conclusioni: la PDT può portare ad una stabilizzazione a breve termine dell’acuità visiva, ad un decremento di un rischio di una rilevante riduzione della sensibilità al contrasto e ad un miglioramento degli indici perimetrici in occhi affette da degenerazione maculare essudativa prevalentemente classica nei quali si è riscontrata una riduzione delle dimensioni fluorangiografiche delle membrane coroideali neovascolari. Ciò comporta un miglioramento della visione parafoveale (confortato dai risultati dei test per la sensibilità al contrasto e dagli indici perimetrici), con particolare soddisfazione da parte dei pazienti, che affrontano con più facilità tutte le attività giornaliere, grazie ad un globale miglioramento soggettivo delle condizioni visive
Ganglion cell complex evaluation in exudative age-related macular degeneration after repeated intravitreal injections of ranibizumab
Full text linkPurpose. To detect the effects of intravitreal ranibizumab injections on GCC in patients with wet AMD. Methods. 32 wet AMD eyes were selected and submitted at three ranibizumab injections. RTVue-OCT GCC and MM5 protocol were performed before treatment and twenty days after each injection. Results. At baseline mean GCC thickness was 93.9 ± 18.5 μm. Twenty days after each intravitreal injection it was, respectively, 85.8 ± 10.1, 86.5 ± 9.3, and 91.1 ± 11.5 μm, without statistical significance. A significant improvement in visual acuity (P = 0.031) and a reduction of mean foveal (P = 0.001) and macular thickness (P = 0.001) were observed. Conclusion. The clinical results confirm therapeutic efficacy of intravitreal injections of ranibizumab in wet AMD. A contemporary not statistically significant reduction of GCC thickness suggests that the loading phase of ranibizumab does not have any toxic effects on ganglion cell complex
Parry-Romberg syndrome
No full textParry-Romberg syndrome is a progressive hemifacial atrophy involving the skin, soft tissues, cartilage, and underlying bone.1 It was described first by Parry in 1825,2 then Romberg in 1846,3 and Eulenberg in 1871.4 It is more frequent in women, with a female-to-male ratio of 1.5:1.5 In Rogers’ study of 772 cases, only 5 percent showed bilateral atrophy.5 In most cases, the atrophy is unilateral.6 Parry-Romberg syndrome can appear in early infancy or adolescence. The most serious cases are manifest earlier, with atrophy of the underlying structures.6 Nevertheless, in a recent study, Jeremy et al.1 reported that there was no relationship between the seriousness of the disease and age of onset. Causes of the disease remain unknown, although various hypotheses have been advanced. The most recent and reliable theory is that there is a genetic alteration in the first stage of the embryogenesis of the central nervous system.7 Other hypotheses include viral or bacterial infections,8 loss of the cervical sympathetic nerve9,10 after peripheral neuritis of the trigeminal nerve,11,12 and trauma,13 and still others suggest that the disease is a form of scleroderma.4,5,8 . Progressive hemifacial atrophy is often confused with scleroderma, which led Singh and Bajpai14 to establish criteria to distinguish these two diseases.6 Facial atrophy is localized and progresses according to the specific distribution of one or more branches of the fifth cranial nerve15: in 50 percent of cases, the upper two-thirds of the involved hemiface show the classic “coup de sabre.” The whole face can become involved as the disease progresses. In its late appearance, the lower third of face is commonly affected, with rare involvement of the upper third.16 In some cases, half of the tongue and the corresponding salivary glands are involved.6 The most common eye symptoms are progressive enophthalmos, restrictive and paralytic ocular muscle pathologies, and Duane syndrome.17,18 We present a case of serious progressive hemifacial atrophy treated with grafting of biomaterials, specifically porous polyethylene implant for reconstruction of the orbital bone tissue and a gel polymer comprising networks of alkylimide groups (4 percent) and water (96 percent) for filling the soft tissue
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