1,721,043 research outputs found
[Chromosomal proteins during ontogenesis of Gallus gallus. III. Non-histone proteins in the heart].
No full textBiological Effects of Licochalcones
Full text linkMedicinal plants and their natural bioactive molecules, are evaluated as the foundation for health preservation and care of humanity. The licorice root, known as "Radix Glycyrrhizae", is a perennial plant that comes from Mediterranean countries, central to southern Russia, Asia, Turkey, Iraq and Iran. The licorice root has been used in traditional Chinese medicines for centuries and has been defined as "the progenitor of herbs". The name 'Licorice' is derived from the ancient Greek word Glukurrhiza, meaning 'sweet root'. It consists of approximately 30 species, however, the most common ones consist of Glycyrrhiza glabra L., Glycyrrhiza uralensis Fisch and Glycyrrhiza Inflata. In addition, the licorice root contains chalcones, which are a part of an important class of natural products and are precursors of flavonoids. Chemically, chalcones are composed of two aromatic rings associated with α, β-unsaturated α-carbon ketone, representing the prima nucleus of the structure. They have been classified, according to chemical structures, in Licochalcone A, B, C, D, E, F and G. This review aims to highlight all the in vitro and in vivo studies that have been conducted on the licochalcones, extracted from Glycyrrhiza species. The main effects are as follows: anti-inflammatory, antioxidant, anticancer, antimicrobial, antiviral, antiallergic, antidiabetic, hepatotoxic and osteogenic. It is important to implement the introduction of biologically active natural molecules from the bench (research) to the bedside (clinical practice). However, in the future, it is required to conduct additional studies to validate these biological effects
[Characterization of proteases contained in the non-histone protein fraction of the chromatin in human lymphocytes].
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Karyologic analysis in erythroleukemia
No full textWe report the cytogenetic data of two patients with erythroleukemia showing the chromosome Ph'. In one case the chromosome Ph', as revealed with the GTG band technique was the result of a translocation involving the chromosomes 19 and 22. The aim of this work is to provide more contribution to the knowledge of the origin of the Ph' and to give data in the field of this disease for which few cytogenetic data are available after the introduction of the banding techniques
Morphological patterns in rats with glomerulonephritis induced by long-term exposure to mercury.
No full textEnhanced adherence of human uremic erythrocytes to vascular endothelium: role of phosphatidylserine exposure
Full text linkBackground. The exposure of phosphatidylserine (PS) on the outer leaflet of erythrocyte membrane may have several pathophysiological consequences including increased erythrocyte adherence to endothelial cells, a finding that seems relevant in pathologies with reported vascular injury.
Methods. Because PS externalization increases in erythrocytes from patients suffering from chronic uremia, which is frequently associated with vascular damage, the adherence of uremic erythrocytes to human umbilical vein endothelial cell (HUVEC) monolayers and the role of PS exposure on such cell-cell interaction were studied.
Results. The number of uremic erythrocytes adhering to HUVEC was markedly greater than with normal erythrocytes and significantly correlated (r = 0.88) with the percentage of PS-exposing erythrocytes in the population. Adhesion to the monolayers was significantly decreased when uremic erythrocytes were preincubated with either annexin V or PS-containing liposomes, and was strongly greater for PS-positive than PS-negative fluorescence-activated cell sorter (FACS)-sorted uremic erythrocytes. Binding occurred preferentially in the gaps of HUVEC monolayers and was enhanced by matrix exposure. Uremic erythrocytes adhered to immobilized thrombospondin, and binding to endothelial cells was significantly reduced when monolayers were incubated with antibodies to thrombospondin.
Conclusions. These findings suggest that PS externalization may promote increased uremic erythrocyte adhesion to endothelium, possibly via a direct interaction with matrix thrombospondin
Reduction of free radicals in multiple sclerosis: effect of glatiramer acetate (Copaxone(R)).
Full text linkFree radicals have been found in high concentrations within inflammatory multiple sclerosis (MS)
lesions. The superoxide anion (O2
–) reacts rapidly with nitric oxide (NO), producing peroxynitrite
(ONOO–). Glatiramer acetate (GA) is a specific MS immunomodulator that induces the synthesis of
Th2 cytokines, and reduces the frequency of relapses and the formation of active brain lesions. Proinflammatory
cytokines could play a role in free radicals production in the peripheral immune system as
well as in the central nervous system (CNS). The effect of GA on iNOS, superoxide radicals (O2
–) and
3-nitrotyrosine production by peripheral blood adherent mononuclear cells (PBAMs) was assessed.
Our findings demonstrate that in vitro GA reduced spontaneous and LPS-induced iNOS,
3-nitrotyrosine, NO and O2
– production, and that similar inhibition can be demonstrated ex vivo in
mononuclear cells obtained from GA-treated patients. The inhibition of the production of free radicals
in PBAMs may represent a new therapeutic mechanism against inflammation during M
Trichinella spiralis infection is mediated by MCP-1 and MIP-2, while echinococcus granulosus is strongly mediated by MCP-1, but not MIP-2
No full textChronic granulocytic Leukemia with loss of Philadelphia chromosome and development of Philadelphia negative diploid clone.
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