1,733,452 research outputs found
Acoustic sensing of renal stone fragmentation in extracorporeal shockwave lithotripsy
This thesis describes the research carried out by the author on the exploitation of acoustic emissions
detected during extracorporeal shockwave lithotripsy (a non-invasive procedure for the treatment of
urinary stones) to develop a new diagnostic system. The work formed part of a research project on
lithotripsy undertaken by the University of Southampton in collaboration with Guy's and St Thomas'
NHS Foundation Trust (London) and a UK based company, Precision Acoustics Ltd (Dorchester). It
takes to a clinical conclusion the proposition made by Leighton and Coleman in 1992 that it might be
possible to build a sensor which would automatically exploit these passive acoustic emissions to
monitor the efficacy of a lithotripsy treatment. The work, predominantly experimental, involved both
in vitro and in vivo investigations. In particular, a first prototype diagnostic system (i.e. sensor plus
analysis software) was developed and tested in vitro during trials which included the use of a novel
cavitation sensor (on loan from the National Physical Laboratory, Teddington) and stone phantoms
designed by the author. This initial system was, then, refined and tested during clinical trials that
involved 130 patients. A preliminary trial on 51 patients aimed at refining the system and gathering
knowledge on the features of emissions recorded in vivo to produce an on-line monitoring system.
This trial was followed by other two trials that compared the output of the on-line acoustic system
against the ‘gold standard’ X-Ray assessment of treatments outcomes. The former of these two trials
involved 30 patients, and empirically defined the values of the key parameters (identified during the
in vitro tests) that would be used as the basis of the diagnosis. In particular, a classification rule of
treatments as being successful or unsuccessful was identified, and shown to agree significantly
(kappa=0.95) with the ‘gold standard’ follow-up assessment. The latter trial tested the final system
on 49 patients and confirmed an accurate treatment classification (kappa=0.94) in terms of the
successful/unsuccessful criterion
ISPA- Istituto di Studi sulla Pubblica Amministrazione
Comitato Scientifico
Mario Comba
Marcello Fedele
Maurizio Ferrera
Ettore Rotelli
Stefano Sepe
Gruppo di Ricerca
Maurizio Curtarelli
Giovanni Damiano
Stefania Farsagli
Alessandra Minà
Carmine Pappalard
E Trattato d'accompagnamento
del celebre Maestro Fedele Fenaroli. E Trattato d'accompagnamento / di Luigi RossiUntertitel: Il tutto forma un complesso di dottrina armonica teorica pratica fondata sulle basi della scuola di Napol
Il Novecento musicale postmoderno di Fedele d'Amico
Visione postmoderna del Novecento di Fedele d'Amic
Il Gradus as Parnassum di Fedele Fenaroli
Illustrates the structure and goals of the treatise Regole e partimenti by Fedele Fenarol
Economia dei popoli e degli Stati 3: La proprietà / Fedele Lampertico
3: La proprietà / Fedele Lampertico
Milano : Fratelli Treves, 1876
X, 366 p. ; 18 cm
Economia dei popoli e degli Stati 2: Il lavoro / Fedele Lampertico
Il lavoro / Fedele Lampertico
Milano : Fratelli Treves, 1875
XII, 400 p. ; 19 cm
Giammaria Ortes e la scienza economica al suo tempo : studi storici economici / di Fedele Lampertico
Giammaria Ortes e la scienza economica al suo tempo : studi storici economici / di Fedele Lampertico
Venezia ; Torino : Antonelli e Basadonna, 1865
350 p. ; 18 cm
Fedele
El relato Fedele fue publicado originariamente en Fedele e altri racconti (Milán, 1887)
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