1,721,226 research outputs found
Produktionsverhältnisse und sozialer Konflikt. Die bremische Schiffswerften zwischen dem Ersten Weltkrieg und der Räterepublik (1914-1919)“
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Die „unruhige Arbeiterschaft“. Rüstungsproduktion und Arbeiterbewegung in einer U-Boot-Werft. Die AG „Weser“ im Ersten Weltkrieg
No full textPlacental vascular indices (VI, FI and VFI) in intrauterine growth retardation (IUGR). A pooled analysis of the literature
No full textObjective: I performed a systematic review and pooled analysis to study the utility of the placental vascular flow indices vascularization index (VI), flow index (FI) and vascularization flow index (VFI) in the prediction or identification of in-utero growth restriction (IUGR). Method: A comprehensive literature search for relevant studies was conducted using PubMed and Web of Knowledge databases. Included were cohort or case-control studies which reported (1) the statistical position and dispersion of vascular indices in a population of normal pregnancies at various trimesters of pregnancy; (2) correlation between vascular indices and gestational age; or (3) the vascular index values stratified according to the presence of SGA/IUGR versus a population of controls. Results: Seven studies met the criteria of inclusion, for a total of 788 controls and 82 SGA cases in the first trimester, and 169 controls and 80 IUGR cases essentially enrolled in the 3rd trimester. After normalization of the means, the pooled detection rates (DRs) at a 10% false positive rate were 32.5%, 53.8% and 51.0%, respectively, for the vascular indices VI, FI and VFI in the third trimester. No significant discriminant ability was detected in the first trimester. Conclusion: A significant DR for IUGR was demonstrated only in the third trimester, thus limiting the utility of vascular indices to predict IUGR. VI and VFI are more reliable and yield better DR and better performance in terms of homogeneity than FI and should be evaluated in the management of third trimester IUGR and prediction of outcome. © 2015 John Wile
Systematic review on first trimester three-dimensional placental volumetry predicting small for gestational age infants
No full textObjective: A systematic review and pooled analysis was carried out to estimate (i) the reference values and (ii) the potential value of measuring the first-trimester 3D-placental volume (PV) for predicting small for gestational age (SGA) infants. Method: A comprehensive literature search for relevant studies was conducted using the PubMed and Web of Knowledge databases. A simulation model was generated to calculate the detection rate (DR) of the PV for SGA infants. A random variable was generated having the same number of cases, and the same means and standard deviation as those reported in the articles considered for the analysis. Results: For the evaluation of the normal values of PV, 12 studies met the inclusion criteria. Four also produced an equation for PV estimation at 11 to 14weeks. The weighted mean PV [±standard error of mean (SEM)] of 7519 cases was 59.40±1.533mL. For the estimation of PV performance in predicting SGA, five studies were included. The DR of the PV was 24.7% (19.3-30.1) at a 10% false-positive rate. Conclusion: The mean PV estimation of the studies analyzed was burdened by a high degree of heterogeneity. Instead, discordant results were reported for the possible prediction of SGA infants using PV. Surprisingly, just two articles reported the DR for SGA infants and also had proper statistical power. The discriminatory ability of using PV alone for predicting SGA appears to be modest, but could successfully be integrated into a multivariable screening method for SGA infants
The Role of RNAs and microRNAs in Non-Invasive Prenatal Diagnosis
No full textIn this paper, all possible clinical applications of circulating mRNA and miRNA for non-invasive prenatal diagnosis appearing in the medical literature so far are described. Data from the literature have also been reported and commented on along with some possible future applications
Congenital heart defects: is it time to explore maternal blood for a non-invasive genetic screening test?
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