93 research outputs found

    Temporomandibular Joint Pain is Negatively Correlated to TNF Alpha and Osteoprotegrin Content in Synovial Fluid in Patients with Juvenile Idiopathic Arthritis.

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    Objective: Temporomandibular joint (TMJ) involvement occurs in up to 80% of children with juvenile idiopathic arthritis (JIA). Little is known with regard to the complexity of the protein profile in synovial fluid (SF) from JIA arthritis during growth as compared to both JIA and rheumatoid arthritis (RA) of adults. Design: Synovial fluid was collected from 54 joints/30 patients with TMJ arthritis (JIA 35 joints/20 patients, JIA adults 9 joints/5 patients, RA 10 joints/5 patients). Three cytokines and seven bone markers were quantified using Luminex multiplex assays and compared to demographic and clinical data of function and pain. Results: Pain (spontaneous and upon palpation) and duration of pain were all negatively correlated with the TMJ SF content of tumor necrosis factor (TNF)-α. The level of Adrenocorticotropic hormone (ACTH) was negatively correlated to TMJ pain upon palpation and post-treatment pain and function. The concentration of ACTH was significantly lower in SF in JIA (1.4 ± 2.8 pg/ml) compared to adults with JIA (4.7 ± 12.2 pg/ml) and significantly higher compared to adults with RA (0.8 ± 1.5 pg/ml). Osteoprotegerin (OPG) was negatively correlated to spontaneous pain. Conclusions: Our results indicate that the local concentrations of TNF-α, ACTH and OPG in TMJ fluid may not contribute to TMJ pain and tissue destruction in JIA/RA patients. © 2014 Olsen-Bergem H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

    Damage detection in semiconductor devices by non-linear elastic wave spectroscopy

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    Semiconductor devices can be found everywhere in our daily lives, for example in self-driving cars, bank cards and personal devices such as smart phones or notebooks. Once part of these personal devices, one does not want them to show failure. Although reliability of such devices is taken into account in the design, the fabrication process might lead to the emergence of small damages in the product. Since these damages or their propagation might cause failure of the device, a series of visual inspections and functional tests is part of the fabrication process. The obtained resolution by optical microscopy, currently the state of the art inspection method, is not sufficient for the detection of small damages such as microcracks or damages located inside a sample. To keep improving the reliability of semiconductor devices, these damages need to be detected in another high speed, low cost way.As semiconductor devices shrink in size, their natural vibration frequencies increase and approach theMHz-range. Vibration based damage detection methods might therefore offer an alternative high speed in-situ inspection method. The main goal of this thesis is to identify and experimentally verify vibration characteristics that indicate the presence of damage, with a focus on microcracks, in semiconductor devices. While linear vibration based damage methods have proven to be insensitive to small damages such as microcracks, non-linear vibration based damage detection methods show much higher sensitivities to this type of damage. The non-linear elastic wave spectroscopy (NEWS) of several damaged materials have shown two characteristic phenomena: amplitude dependent natural frequency shifts and the generation of higher harmonics. Both are explained by a phenomenological non-linear hysteric elastic model. While the applicability of NEWS is proven for several materials, its performance for silicon, in particular at microscale, is still unknown.Mechanical Engineering | Micro and Nano Engineerin

    A geometric flow on noncompact affine Riemannian manifolds

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    In this paper, we obtain the existence criteria for a geometic flow on noncompact affine Riemannian manifolds. Our results can be regarded as a real version of Lee-Tam [19]. As an application, we prove that a complete noncompact Hessian manifold with nonnegative Hessian sectional curvature and bounded geometry is diffeomorphic to Rn\mathbb{R}^n if its tangent bundle has maximal volume growth.Comment: arXiv admin note: text overlap with arXiv:math/0504422, arXiv:1708.00141 by other author

    Creativity and Its Necessity in Teaching and in the Administration of Schools

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    As a research exercise, the study of creativity has long been the province of psychologists. In recent y ears, administrators have researched the creativity literature and have encouraged administrative practitioners to accelerate discovery and increase effectiveness of their organizations through more efficient use of their personnel. The author discusses why and how school administrators must manage schools creatively if creativity is to be fostered in the classroom

    Hyperspectral Imagery Classification Using Sparse Representations of Convolutional Neural Network Features

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    In recent years, deep learning has been widely studied for remote sensing image analysis. In this paper, we propose a method for remotely-sensed image classification by using sparse representation of deep learning features. Specifically, we use convolutional neural networks (CNN) to extract deep features from high levels of the image data. Deep features provide high level spatial information created by hierarchical structures. Although the deep features may have high dimensionality, they lie in class-dependent sub-spaces or sub-manifolds. We investigate the characteristics of deep features by using a sparse representation classification framework. The experimental results reveal that the proposed method exploits the inherent low-dimensional structure of the deep features to provide better classification results as compared to the results obtained by widely-used feature exploration algorithms, such as the extended morphological attribute profiles (EMAPs) and sparse coding (SC)

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    Projeto gráfico de história em quadrinhos com referências em elementos culturais

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    Este trabalho tem como objetivo o desenvolvimento de uma história em quadrinhos de autoria própria cujo conceito seguirá inspirações de elementos culturais do estado do Rio Grande do Sul e do Brasil. O projeto contempla o desenvolvimento gráfico conceitual de uma publicação impressa, e analisa e desenvolve os passos para a criação de uma história em quadrinhos. O trabalho apresenta uma explanação sobre os quadrinhos e sua história, analisa e detalha os elementos dos quadrinhos e mostra o processo de criação do projeto A Jornada de Arani, seguindo a metodologia do autor. Considerou-se as diferentes formas de expressão dos quadrinhos, assim como o potencial como objeto de entretenimento e comunicação que este tipo de material pode proporcionar.This project is concerning the development of a Comic Novel by own making, where-with its concept will be created following inspirations on elements of local culture of the state of Rio Grande do Sul and Brazilian culture. The assignment includes the conceptual graphic development of a printed publication and analyzes the steps to create a comic book. The paper presents an explanation of comics and its history. Also details and reviews the comics elements leading to the process of creation of the story The Journey of Arani, following the author's methodology. Regarding the creation of this project, the author considers the different ways of ex-pression of comics, as well the potential of entertainment and communication that a publi-cation like this can provide
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