1,723,311 research outputs found
Gli “oggetti” della poesia comico-oscena del Medioevo italiano (con una proposta di lettura per il sonetto Volesse Iddio che tti paresse il vino di Lorenzo Moschi)
No full textThis paper analyses the function of objects in obscene comic poems of the 13th and 14th centuries. The first part reviews poems from Il Fiore, the literary dispute between Dante and Forese, work by Rustico Filippi and by the Perugia school, in which certain objects, through obscene metaphors, allude to something beyond their materiality and usual function. The second part offers a reading of a recently published sonnet by Lorenzo Moschi, a petrarchist and dolce stil nuovo poet, the author of 14 irreverent lines on a particular candelabrum that does not refer to anything else, but is also used in an obscene context
Gli strambotti di Francesco Cei. Edizione critica e commento
No full textIl contributo verte sulle rime del poeta fiorentino Francesco Cei, conosciute finora secondo un’edizione basata sulla sola editio princeps e priva di commento. In particolare si concentra sulla sezione conclusiva della raccolta, ovvero sui 17 strambotti, di cui viene fornita l’edizione critica e commentata. Il saggio contiene inoltre un aggiornato profilo biografico del rimatore e alcune riflessioni sulla tradizione manoscritta – finora malnota – che tramanda, in modo piú o meno completo, i testi selezionati.This essay concerns the verses of Florentine poet Francesco Cei. Until today these poems were known only through the editio princeps, and lack a commentary. More precisely, this essay focuses on the final part of Cei’s collection of poems, that is, 17 “strambotti”, of which the author offers here a critical edition and a commentary. In this essay one can also find an up-to-date biographical profile of Cei and some reflections on the manuscript tradition of his texts selected here. Previously little known, the witnesses making up this tradition report either only some of Cei’s “strambotti” or all of them
Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance
No full textNucleophosmin (NPM1) is a ubiquitously expressed protein and is one of the most abundant proteins found in the nucleolus. Naturally occurring mutations in the C-terminal domain of nucleophosmin (Cter-NPM1) are found in similar to 30% of patients with acute myeloid leukemia (AML). These mutations cause changes at the C terminus of NPM1 that lead to denaturation of the protein, a critical factor in determining aberrant translocation of NPM1 to the cytosol. Hence, this protein system represents an ideal candidate to investigate the relations between folding and unfolding and disease. Here we report the characterization of the folding and unfolding kinetics of Cter-NPM1. Data reveal that this small helical domain folds via a compact denatured state, displaying a malleable residual structure. Moreover, analysis of folding rate constants measured under different experimental conditions suggests that the existence of a preorganized structure in the denatured state accelerates folding, implying a native-like residual structure. Because a major feature of Cter-NPM1 mutants responsible for AML is a reduction in stability of the protein and thus prevalence of a denatured state even under physiological conditions, our findings may pave the way to further studies with the aim of designing chemicals capable of interacting with the "pathological" mutants to stabilize the native conformation.-Scaloni, F., Gianni, S., Federici, L., Falini, B., Brunori, M. Folding mechanism of the C-terminal domain of nucleophosmin: residual structure in the denatured state and its pathophysiological significance. FASEB J. 23, 2360-2365 (2009
Z2-γ: An Application of Zienkiewicz-Zhu Error Estimator to Brain Tumor Detection in MR Images
No full textBrain tumors are abnormal cell growth in the brain tissues that can be cancerous or not. In any case, they could be a very aggressive disease that should be detected as early as possible. Usually, magnetic resonance imaging (MRI) is the main tool commonly adopted by neurologists and radiologists to identify and classify any possible anomalies present in the brain anatomy. In the present work, an automatic unsupervised method called Z2-γ, based on the use of adaptive finite-elements and suitable pre-processing and post-processing techniques, is introduced. The adaptive process, driven by a Zienkiewicz-Zhu type error estimator (Z2), is carried out on isotropic triangulations, while the given input images are pre-processed via nonlinear transformations (γ corrections) to enhance the ability of the error estimator to detect any relevant anomaly. The proposed methodology is able to automatically classify whether a given MR image represents a healthy or a diseased brain and, in this latter case, is able to locate the tumor area, which can be easily delineated by removing any redundancy with post-processing techniques based on morphological transformations. The method is tested on a freely available dataset achieving 0.846 of accuracy and F1 score equal to 0.88
Voci SEGNATURA (1) e SEGNAZIONE per il Tesoro della Lingua Italiana delle Origini (pubblicate in rete sul sito http://tlio.ovi.cnr.it/TLIO/)
No full textVoci PERFIDAMENTE, PERFIDEZZA, PERFIDIA, PERFIDIARE, PERFIDIOSO, PERFIDITÀ e PÈRFIDO per il Tesoro della Lingua Italiana delle Origini (pubblicate in rete sul sito http://tlio.ovi.cnr.it/TLIO/)
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Lasiodactylus falini Cline, new species
No full textLasiodactylus falini Cline, new species (Figs. 3, 5, 8, 11, 14, 17, 20, 24, 29, 30, 36, 40, 44) Type Series. Holotype: $, Data Labels: Suriname, Marowijne, Palumeu, ca 160 m, 3 8 20 9 56 0 N: 55 8 26 9 18 0 W, 5–9 July, Z.H. Falin and D. Konoe collr., SUR1F99 185, ex: flight intercept trap; Bar Code Label, SM0164807, KUNHM-ENT; HOLOTYPE, Lasiodactylus falini, A.R. Cline des. 2002. Deposited SEMC. Paratype: #, Data Labels: French Guiana; Entomotech Lodge, 30 km SE Roura on Kaw Rd., 1-12-XII-2002, J.E. Eger; 04 8 33.570 9 N, 052 8 12.433 9 W, 300 m; PARATYPE, Lasiodactylus falini, A.R. Cline des. 2003. Deposited in FSCA. 2) L. brunneus, dorsal aspect of head. Scale bars ¼ 0.5 mm. Description. Length 9.0 mm, Width 4.1 mm, Depth 2.0 mm. Body uniformly dark reddish brown/black. Head with labrum deeply indented halfway to posterior border. Labrum glabrous with a few scattered minute punctures. Clypeus broadly emarginate at clypeo-labral suture. Maxillary palpi elongate with sensillar area not extending completely across apex (Fig. 3). Vertex with small shallow fovea next to each orbit. Both small and large punctures evenly dispersed across head. Axillary (supraocular) space extending forward to middle of eye. Antennal scape curved along posterior margin. Eighth antennomere flattened. Antennal club compact, antennomeres 9 and 10 chevron shaped, antennomere 11 somewhat diamond-shaped (Fig. 5). Several short, stiff setae are apparent throughout the coarsely faceted eyes. Pronotum with anterior margin shallowly emarginate, lateral margin widest just before posterior angles, posterior margin with small indentations near posterior angles. Both large and small punctures evenly dispersed across pronotum. Scutellum broadly triangular with several small punctures scattered throughout. Elytra finely, densely fimbriate along lateral margin from humeri to apex. Humeri moderately produced. Elytral margins narrowly explanate from humeri to five-sixths the length of the elytra. Punctures deeply impressed and in double rows, a row of minute punctures each bearing a minute golden seta between the double rows. Pygidium broadly triangular, narrowed at apex, with disperse setae scattered, apical margin bearing short setae laterally and longer setae medially (Fig. 11). Mentum with minute punctures along margin. Prosternal process in lateral aspect angled from anterior origin to a flattened area over procoxae, with short vertical face posteriorly (Fig. 8). Prosternal process in ventral aspect greatly expanded behind procoxae with many short setae along apical border. Protibia shallowly curved along medial border. Apical spine short, as long as first tarsomere. Lateral margin finely, narrowly crenulate (Fig. 14). Mesotibia similar to L. brunneus, except for broad teeth on the apical border (Fig. 17). Metatibia with short slender spines along entire length of lateral margin, and only present in apical half of medial margin.Apical margin armed with 16–18 teeth (Fig. 20). Apical spine large, as long as first two tarsomeres combined. Male genitalia with anal sclerite (¼ tergite VIII) broadly convex with shallow fossa for reception of tegmen, apicolateral corners convex (Fig. 24). Numerous setae present on apical border, becoming longer medially. Tegmen small and compact, basal margin with shallow concavity (Fig. 29). Scattered, short setae in apical one-half not extending to dorsal side of tegmen, with longer tuft of setae basally. Median lobe large, robust, greater than 3/4 length of tegmen, with simple apical opening (Fig. 30). Ovipositor with gonocoxites fused from base to apical one-third of structure (Fig. 40). Group of small basal sensilla, and larger sensilla scattered along apical two-thirds of gonocoxites. Terminal appendage originating from small pit on lateral margin near apex. Terminal appendage bearing seven setae from apex. Two setae overlapping at the extreme tip of the gonocoxites. Paraprocts with lateral and medial margins heavily sclerotized (Fig. 36). Apical margin tapered into broad point at apex. Basal medial margin prolonged into a terminal ridge that extends over the base of the gonocoxites. Ovipositor long and slender. Etymology. The specific epithet honors the collector of the Holotype, Zack Falin. Diagnosis. Non-genitalic characters delimiting this species include: distinct large and small puncture pattern on the head, large size of the axillary space behind the eyes, maxillary palpi elongate with a sensillar region not extending across the apical margin, and lateral aspect of the prosternal process somewhat produced, with a short vertical face. The following genitalic features distinguish L. falini from the other known species: tegmen relatively small in comparison to the large median lobe, shorter setae on tegmen not extending around apex to dorsal surface, anal sclerite with concave apicolateral corners, gonocoxites of ovipositor distinctly fused in apical half, basal aggregation of sensilla on gonocoxites, seven setae originating from terminal gonocoxite accessory appendage, and sclerotized basal ridge on paraproct that partially covers the gonocoxite base. Distribution. The holotype was collected at a locality near Palumea on the Tapanahony River in Marowijne province, southern Suriname. The paratype was collected in Guyanan Shield forest in neighboring French Guiana (Fig. 44). Biology. The village at the type locality is surrounded by a semi-circle of actively farmed fields, partially cut secondary forest, older secondary forest, disturbed primary forest, and undisturbed forest several kilometers away from the village. The flight intercept trap was in the disturbed primary forest. The forest there is classic Guyanan Shield forest, found throughout the interior of Suriname and the Guyanas. The forest where this particular trap was placed was disturbed only in that the larger, economically valuable/useful trees had been removed, otherwise it was virtually indistinguishable from the surrounding pristine forest (Z. Falin pers. comm.).Published as part of Cline, Andrew R. & Carlton, Christopher E., 2004, Review of Lasiodactylus Perty, with Descriptions of Three New Species (Coleoptera: Nitidulidae: Nitidulinae), pp. 355-368 in The Coleopterists Bulletin 58 (3) on pages 357-359, DOI: 10.1649/63
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