1,721,062 research outputs found
Reactive oxygen species, health and longevity
Full text linkReactive oxygen species (ROS) are considered responsible of ageing in animal and humans. Mitochondria are both source and target of ROS. Various strategies to reduce ROS production have been considered to extend lifespan. Caloric restriction, exercise, and antioxidants are thought to be able to protect cells from structural and functional damage. However, there is evidence that ROS production has a detrimental effect on health, but at physiological levels are necessary to stimulate longevity. They play an important effect on secondary signal transduction stimulating innate immunology and mitochondriogenesis. During exercise at moderate intensity, skeletal muscles generate ROS that are necessary for the remodelling of the muscular cells. Physical inactivity determines excessive ROS production and muscle atrophy. Caloric restriction (CR) can reduce ROS generation and improve longevity while antioxidant supplementation has shown a negative effect on longevity reducing the muscle adaptation to exercise and increasing mortality risk in patients with chronic diseases. The role of ROS in chronic diseases in also influenced by sex steroids that decrease in aging. The physiology of longevity is the result of integrated biological mechanisms that influence mitochondrial function and activity. The main objective of this review is to evaluate the effects of ROS on mitochondriogenesis and lifespan extension
Il «Protocollo di san Benvenuto» dopo Benvenuto Scotivoli: vescovi e notai a Osimo tra Duecento e Quattrocento
No full textIl contributo presenta i risultati di una prima indagine condotta sul Protocollo di san Benvenuto, un registro vescovile conservato presso l’Archivio diocesano di Osimo, contenente nella maggioranza dei casi imbreviature notarili di atti prodotti da una serie di vescovi dal XIII fino al XV secolo. Consta di 315 carte in pergamena, dal 1882 suddivise in tre tomi, assemblate mediante l'unione di fascicoli originariamente autonomi oppure appartenenti a volumi diversi. Il presente studio è circoscritto alla parte finale del terzo tomo, tralasciando i fascicoli relativi a Benvenuto Scotivoli, amministratore e vescovo della chiesa osimana dal 1263 al 1282, quantitativamente prevalente rispetto al resto, oggetto di un contributo in corso di stampa. In particolare, si intende offrire spunti di riflessione sul complesso rapporto tra vescovo e notai
Plasma Membrane perturbation induced by Tributyltin Chloride on density-separated Trout Erythrocytes
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Steady-state Fluorescence and circular dichroism of trout hemoglobins I and IV interacting with tributyltin.
No full textEFFECT OT TRYBUTYLTIN ON TROUT BLOOD CELLS:CHANGES OF MITOCHONDRIAL MORPHOLOGY AND FUNCTIONALITY.
No full textKinetic and spectroscopic properties of the cyanide complexes of ferrous haemoglobins I and IV from trout blood
No full textAnalysis of stress induced gene expression in trout red blood cells following tributyltin chloride exposure.
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