1,720,982 research outputs found

    Come il federalismo fiscale può salvare il Mezzogiorno

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    Questo volume scritto a quattro mani con Piercamillo Falasca esamina taluni problemi strutturali del Mezzogiorno italiano, suggerendo di superare la logica dello Stato moderno nazionale e di affermare un nuovo protagonismo dei territori, stimolando ogni realtà a competere e a responsabilizzarsi

    MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF POLYNUCLEOTIDE PHOSPHORYLASE FROM THE ANTARCTIC EUBACTERIUM PSEUDOALTEROMONAS HALOPLANKTIS

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    Polyribonucleotide phosphorilase from the psychrophilic Antarctic eubacterium Pseudoalteromonas haloplanktis (PhPNPase) has been purified. This enzyme catalyzes both the RNA polymerisation and degradation reaction, showing the highest activity at temperatures below 40 degrees C. PhPNPase is quite sensitive to heat treatment and it is endowed with remarkable halotolerance

    Un sistema informativo socio-sanitario basato su un indice sintetico di fragilità: l’Ausl di Ravenna

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    This study provides a description of an information system to be used in the health and social networ

    Thyroid transcription factor 1 activates the promoter of the tyrothropin receptor gene

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    The TSH receptor (TSHr) is one of the most important thyroid differentiation markers. The binding of the TSH hormone to its receptor is an essential step in the modulation of thyroid function and differentiation. Here we report that the thyroid transcription factor 1 (TTF1), a transcription factor essential for thyroid-specific gene expression, binds to the TSHr minimal promoter. The promoter, when mutated at this binding site, shows a decreased activity in thyroid cells. In cotransfection experiments in nonthyroid cells, TTF1 is able to trans-activate the TSHr minimal promoter. This finding strengthens the importance of TTF1 in the maintenance of thyroid differentiation. The promoters of the main thyroid differentiation markers thyroglobulin, thyroperoxidase, and now TSHr, are regulated by TTF
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