1,721,101 research outputs found
Treatment of multiple sclerosis fatigue with the synthetic psychoactive drug modafinil
No full textMultiple sclerosis (MS) is a complex disorder characterized by a broad spectrum of symptoms that evolve throughout the disease. Symptoms can be categorized as visible and invisible based on external sight recognition. However, although others poorly recognize it, invisible symptoms such as mood dysfunction, neuropathic pain, or fatigue can significantly affect activities of daily living and the quality of life of people with MS (PwMS). PwMS frequently complain of fatigue, which has physical or cognitive manifestations. Fatigue in MS does not improve or resolve with rest, and it is disproportionate with respect to the exerted effort. Fatigue management in MS is challenging, and a few pharmacological approaches have been successfully proposed. Among them, the drug modafinil has attracted attention because of its properties as a synthetic psychoactive drug. In this review, we focus on the evidence available to date, supporting the use of modafinil in MS fatigue. However, despite the availability of some trials evaluating the effects of modafinil on fatigue, their contrasting results failed to support its usefulness in fatigue management in MS
Gli effetti dell'apertura di un ipermercato su una porzione del centro storico di Cagliari
No full text
Alternative scenarios of labour flexibility for dock workers in maritime container terminals
No full textInformation relaying systems and driver perception: experimental analysis of variable message sings using eye tracker
No full textUn’analisi sperimentale sulle modalità di composizione dei testi nei pannelli a messaggio variabile (PMV)
No full textNonostante i Pannelli a Messaggio Variabile siano sempre più diffusi nel nostro Paese non si registrano al
giorno d’oggi studi significativi che riguardino la composizione testuale dei messaggi.
Tale aspetto assume una notevole importanza in quanto le parole contenute nel messaggio e la struttura di
quest’ultimo influenzano la corretta comprensione e percezione del testo, come dimostrato da diverse
esperienze scientifiche elaborate in altri paesi (esperienze non totalmente replicabili in Italia per via della
lingua).
Partendo da una valutazione rigorosa della struttura del testo effettuata attraverso paradigmi tipici dell’analisi
testuale, in questo studio è stata valutata l’efficacia della struttura lessicale di tre messaggi inviati in due
giornate distinte nei PMV di una città italiana di medie dimensioni. Il tipo di analisi adottata ha consentito di
individuare gli aspetti maggiormente critici dei testi inviati oltreché alcune norme basilari per una loro corretta
composizione
Road intersection ranking for road safety improvement: comparative analysis of multi-criteria decision making methods
Full text linkThe aim of this paper is to propose a methodology for identifying the most critical road sections in urban networks in terms of road safety. This approach is useful for the managers of the road network when they need to allocate limited financial resources to several critical sections. Since the resources are not always sufficient to solve all road safety issues, they require a methodology that is able to rank the critical sections. Road safety depends on the interaction of several factors so this methodology has to be based on a multicriteria approach. In earlier articles, the authors of this paper first adopted Electre III and later Concordance Analysis as multicriteria methods for ranking critical points in an urban road network. Both methods have some critical elements, associated with threshold choice (Electre III) and ranking procedure (Concordance Analysis). In order to improve the methodology, the authors have selected two further multicriteria methods (Vikor and Topsis), for comparison with the Concordance Analysis and for evaluating which performed best. In order to identify critical sections in a road network, a suitable set of indicators is defined, taking into account geometric and traffic volume criteria. The multicriteria methods are applied to a real case for ranking, from the worst safety conditions to the best, the most critical road intersections within the urban road network, on the basis of eight criteria. The results of all three methods considered are compared and a sensitivity analysis is performed to test the stability of the results. The results show that the Topsis method performs best in determining a complete ranking of the critical road sections, overcoming some negative aspects associated with the other methods
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