67 research outputs found
Riabitare castelli: nuova foresteria in Casa Celli e valorizzazione della connessione tra il Borgo e il Liceo artistico F.A. Grue
No full textLAUREA MAGISTRALEIl progetto “Riabitare Castelli” guarda al borgo come ad una nuova opportunità di ri-abitare, intrecciando memoria, arte e comunità. Il terremoto del 2009 ha segnato profondamente il tessuto urbano e sociale, incidendo sulle dinamiche demografiche e sul legame tra le vecchie e nuove generazioni.
Castelli, celebre per la secolare tradizione della ceramica artistica, trova oggi nella sua arte un valore identitario, preservato e trasmesso dal Liceo Artistico F.A. Grue.
Tra gli obiettivi strategici del Piano di Ricostruzione del 2009 emerge la necessità di riconnettere il centro storico all’istituto d’arte, migliorando l’accessibilità e incentivando un dialogo tra il patrimonio esistente e le nuove generazioni. In quest’ottica, si propone la riqualificazione della “Salita Paradiso”, un percorso che collega il borgo alla scuola.
Nel cuore del centro storico, si propone Casa Celli, attualmente in disuso, come foresteria, in grado di accogliere studenti, artigiani e turisti attraverso un sistema di gestione flessibile e una rotazione stagionale. Da settembre a giugno, ospiterebbe studenti e ceramisti professionisti, generando un ambiente di scambio e sperimentazione artistica. Nei mesi estivi, si aprirebbe invece all’ospitalità turistica, offrendo un’esperienza immersiva nella cultura locale.
Oltre agli spazi abitativi, il progetto valorizza il piano terra come luogo di incontro e condivisione, con laboratori collettivi e ambienti espositivi accessibili all’intera comunità.
Casa Celli si trasforma così in un polo dinamico dove formazione, artigianato e accoglienza si fondono in un modello innovativo di riattivazione della realtà territoriale locale."Riabitare Castelli" project views the village as a new opportunity for re-inhabitation, weaving together memory, art, and community. The 2009 earthquake profoundly impacted the urban and social fabric, affecting demographic dynamics and the bond between older and newer generations.
Castelli, renowned for its centuries-old tradition of artistic ceramics, now finds an identity value in its art, preserved and transmitted by the F.A. Grue Art School.
Among the strategic objectives of the 2009 Reconstruction Plan is the need to reconnect the historic center with the art institute, improving accessibility and encouraging dialogue between existing heritage and new generations. In this perspective, the project proposes the redevelopment of "Salita Paradiso," a pathway connecting the village to the school.
In the heart of the historic center, Casa Celli, currently unused, is proposed as a guesthouse capable of accommodating students, artisans, and tourists through a flexible management system and seasonal rotation. From September to June, it hosts students and professional ceramicists, creating an environment for exchange and artistic experimentation. During summer, it opens to tourism, offering an immersive experience in local culture.
In addition to the living spaces, the project enhances the ground floor as a meeting and sharing place, with collective workshops and exhibition areas accessible to the entire community.
Casa Celli is thus transformed into a dynamic hub where education, craftsmanship, and hospitality merge into an innovative model for reactivating the local territorial reality
Un análisis de la aischrología en los Anécdota (Historia Secreta) de Procopio
No full textThe study of the terminology used by Procopius in the Anecdota (“unpublished writings”), commonly known as the Secret History (Historia Arcana) –which constitutes a form of invective against Justinian and his wife Theodora– offers an insight into the axiology of the culture of the Eastern Roman Empire in the 6th century AD. This paper analyzes the rhetorical elements of aischrology against the emperor and his wife in the work, establishing the Anecdota as an essential source for exploring the cultural values of the period. First, a lexical search is carried out through a classification of the aischrological elements used by Procopius to denigrate the figures of Justinian and Theodora. Then, the semantic interrelationships of the terms present in the text are analyzed, showing the conceptual dependence articulated by the author, thus achieving the composition of a unified and holistic invective discourse of greater forcefulness against the emperor. In effect, this analysis aims to highlight, in addition to the Procopius's rhetorical and compositional resources, some moral conceptions shared between the author and the recipients of the discourse.El estudio de la terminología utilizada por Procopio en los Anécdota (“escritos inéditos”), conocidos comúnmente como la Historia Secreta (Historia Arcana) –que constituye una forma de invectiva frente Justiniano y su esposa Teodora–, ofrece una aproximación a la axiología de la cultura del Imperio Romano de Oriente en el siglo VI d. C. En este trabajo se analizan los elementos retóricos de la aischrología contra el emperador y su esposa en la obra, lo que permite establecer a los Anécdota como una fuente insoslayable para la exploración de los valores culturales del periodo. En primer lugar, se realiza un rastreo léxico a través de una clasificación de los elementos ‘aischrológicos’ empleados por Procopio para denostar las figuras de Justiniano y Teodora. Luego, se analizan las interrelaciones semánticas de los términos presentes en el texto, mostrando la dependencia conceptual articulada por el autor, logrando así la composición de un discurso invectivo unificado y holístico de mayor contundencia frente al emperador. En efecto, este análisis pretende evidenciar, además de los recursos retóricos y compositivos de Procopio, algunas concepciones morales compartidas entre el autor y los receptores del discurso
Post-docetaxel therapy in castration resistant prostate cancer - the forest is growing in the desert.
No full textIn Europe, prostate cancer is the most common cancer among men with 382.000 new cases and 89.000 deaths annually. Historically, androgen deprivation therapy and docetaxel based chemotherapy were the only treatments able to improve survival. Two studies have been published during last few months regarding the management of castration resistant prostate cancer (CRPC) progressed after docetaxel: for the first time second line therapies have been demonstrated to improve prognosis of these patients. The relevance of these trials is the reintroduction of chemotherapy and hormonal therapy in a disease once considered chemotherapy and castration resistant. All these data may change the traditional approach to CRPC but no evidences have came out from recently closed or ongoing clinical trials about the therapeutic algorithm. How to get oriented in this forest? We propose that patient's conditions, response and toxicities reported with previous treatments and, above all, dynamics and evolution of disease may influence the choice of subsequent therapies in docetaxel progressed CRPC. © The Author(s), 2012
MHC immunoevasins: protecting the pathogen reservoir in infection
No full textAlteration of antigen recognition by T cells as result of insufficient major histocompatibility complex (MHC)-dependent antigen-presenting function has been observed in many cases of infections, particularly in in vitro systems. To hide themselves from an efficient immune response, pathogens may act on MHC-related functions at three levels: (i) by limiting the number of potential antigens that can be presented to naive T cells; (ii) by synthesizing proteins which directly affect MHC cell-surface expression; and (iii) by altering the normal intracellular pathway of peptide loading on MHC. Here, we review examples of pathogens' action on each single step of MHC function and we suggest that the result of these often synergistic actions is both a limitation of the priming of naive T cells and, more importantly, a protection of the pathogen's reservoir from the attack of primed T cells. The above mechanisms may also generate a skewing effect on immune effector mechanisms, which helps preserving the reservoir of infection from sterilization by the immune system
Discovering ante litteram models of writing that heals and saves. After Giuseppe Berto, Marianna Procopio
No full textIf the theories that came from America could have had no influence on Berto’s Il male oscuro, an established and successful author in whom I accidentally discovered for the first time an ante litteram model of narrative medicine, much less could they have had on the writing of a rather singular book, published in Padua 1962, with the title Diario e altri testi. The book consists of four parts. The text that interests us is contained in the first of them, subtitled Malattia e morte della madre, and divided into several unnumbered chapters. The author is Marianna Procopio. An atypical case from a literary point of view, Marianna was a housewife born at the end of the nineteenth century in Calabria, with an education that stopped at the third grade, and she wrote for the first time in her life at the age of fifty, after a trauma caused by the death of her mother. This event broke Marianna’s life into two parts
that would never be reunited again and rises in her mind to the disturbing grandeur of an epochal era, placing all the rest of the events in a ‘relative’ time that was either before or after it. Wandering around the rooms of the house in vain search for a presence that is such only in her imagination and dreams, Marianna finds in fixing memories on paper, in reviewing the moments that slowly led her mother to death, in continuously updating the calendar of the anniversary, a catharsis from the suffering that is offered by the liberating function of writing. Marianna Procopio’s Diary is therefore the second ante litteram narrative
medicine model I discovered
Procopio Serpotta e la tecnica dello stucco: un episodio sconosciuto a Monreale, iconografia, attribuzione
No full textThis paper intends to present a church located in the heart of the city of Monreale - Maria SS. degli Agonizzanti - hidden from the tourist road, but mostly neglected by art history studies of Sicily. Its interior decoration, thanks to a recent restoration, offers the opportunity to discover the iconographic program tied to the purpose of its construction: the site of a religious confraternity with the aim of offering alms, care of the sick and the burial of the dead. This study provides iconographic and stylistic comparisons between the stucco sculptures of the church of Monreale with those of the artistic activity of Procopio Serpotta (1679-1755). These comparisons leave no doubt about the authorship and the realization by the sculptor, until now never confirmed with certainty. Furthermore, these sculptures and the entire iconographic program and theological have been studied in this paper with the allegories of the book of Cesare Ripa Iconologia, published for the first time in Rome in 1593, the most extensive repertory of allegorical images taken in the visual arts. The great success of this work - the author of five editions of living, eighteen posthumous seventeenth, eighteenth fifteen - marks the modern revival of interest in the world of symbols and images that, combined with the word of men of letters, they become in effect a new language. It was Donald Garstang to rediscover critically Giacomo Serpotta (1656-1732) and his school of plasterers with the publication of the monograph in English, written in 1984 by passionate and admired full participation of important contributions documentaries, even without a direct knowledge of some works within the island
Procopio Serpotta e la tecnica dello stucco: un episodio sconosciuto a Monreale, iconografia, attribuzione
No full textThis paper intends to present a church located in the heart of the city of Monreale - Maria SS. degli Agonizzanti - hidden from the tourist road, but mostly neglected by art history studies of Sicily. Its interior decoration, thanks to a recent restoration, offers the opportunity to discover the iconographic program tied to the purpose of its construction: the site of a religious confraternity with the aim of offering alms, care of the sick and the burial of the dead. This study provides iconographic and stylistic comparisons between the stucco sculptures of the church of Monreale with those of the artistic activity of Procopio Serpotta (1679-1755). These comparisons leave no doubt about the authorship and the realization by the sculptor, until now never confirmed with certainty. Furthermore, these sculptures and the entire iconographic program and theological have been studied in this paper with the allegories of the book of Cesare Ripa Iconologia, published for the first time in Rome in 1593, the most extensive repertory of allegorical images taken in the visual arts. The great success of this work - the author of five editions of living, eighteen posthumous seventeenth, eighteenth fifteen - marks the modern revival of interest in the world of symbols and images that, combined with the word of men of letters, they become in effect a new language. It was Donald Garstang to rediscover critically Giacomo Serpotta (1656-1732) and his school of plasterers with the publication of the monograph in English, written in 1984 by passionate and admired full participation of important contributions documentaries, even without a direct knowledge of some works within the island
Prolonging the Growing Season in Colder Climates to Supplement Drought-Induced Reductions of the Nation’s Food Supply in the West
No full textPromoting Hoop Houses As a Means to Increase Food SupplySummer 2015Accompanied by video fil
Current approaches to assess HIV-1 persistence.
No full textThe persistence of HIV within long-lived HIV-infected CD4 T cells is the primary obstacle towards HIV eradication and numerous strategies are currently being evaluated to target and kill HIV-infected cells to ultimately find a cure. HIV reservoirs are classically quantified by standard methods such as integrated HIV DNA (Alu PCR) and/or quantitative viral outgrowth assay; however, recent technical advances may offer new opportunities to comprehensively assess the impact of clinical interventions.
Digital droplet PCR, tat/rev-induced limiting dilution analysis, enhanced quantitative viral outgrowth assay, and whole genome sequencing technologies offer increased precision and/or higher sensitivity to quantify and characterize HIV reservoirs in antiretroviral therapy-treated HIV-infected patients.
The objective of this review is to highlight the characteristics and limits of recent technical advances that may help to monitor the impact of clinical interventions in antiretroviral therapy-treated patients
Sul Proemio degli Anekdota di Procopio
No full textThis paper offers a new analysis of the proem of Procopius’ Anekdota (I 1-10). The author discloses Procopius’ own original rework of, and polished intertextual dialogue with, Greek historians of the V and the IV century BC such as Thucydides and Theopompus (An. I 2-3 ~ Theop. FGrHist 115 T 20a and T 20a+; An. I 4-5 ~ Thuc. I 21.1), thus showing that the proem of the Anekdota is not a mere collection of "topoi". While introducing the Anekdota to his readers, Procopius appears to be self-aware of the fundamental tasks of historical inquiry. He presents his work as a piece of real historical inquiry, and specifically, as an aetiological supplement to the Bella
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