104 research outputs found
Infections and Follicular Lymphoma: Is there a Link?
No full textSeveral infectious agents appear to provide a proliferative signal -- "antigen-drive" - that could be implicated in the pathogenesis of various type of Non-Hodgkin Lymphoma (NHL). A classical model of the infection-driven lymphoproliferative disorder is Helicobacter pylori-induced gastric MALT lymphoma, where antibiotic therapy allows the eradication of both the infectious agent and the clonal B-cell expansion. Following the footsteps of this example, several retrospective studies have found a correlation with other pathogens and B-cell Lymphomas, adding new relevant information about pathogenesis and laying the groundwork for chemotherapy-free treatments. Although no clear association has been found between infectious agents and Follicular Lymphoma (FL), a growing number of biological and clinical observations suggests the interaction of physiological and pathological microbial populations also in this subtype of lymphoma. In the last few years, epidemiological studies investigating the association of known risk factors and FL found a potential correlation with viral or bacterial infections; moreover, recent findings of the stimulation of FL clones support the importance of microbial exposure to lymphomagenesis and disease progression.In the following review we make an attempt to find tangible evidence for a role of either physiological and pathological exogenous microbial species in the pathogenesis of FL, and try to integrate the findings coming from epidemiological, biological and interventional studies to define future novel treatment and prevention strategies for FL
Efficiency of the distal screw in the distal movement of maxillary molars.
No full textConventionally, noncompliance distal movement of molars relies exclusively on intraoral anchorage. The distal screw, a distal jet appliance supplemented by two paramedian mini-implants, is an innovative alternative. The aim of this study was to evaluate the suitability of this device to move molars bodily and distally.The effects of the distal screw were evaluated in a sample of 18 consecutively treated preadolescent and adolescent individuals (nine females and nine males; mean age at the start of treatment, 11.2 years). Two conical mini-implants (length 11.0 mm, diameter 1.5 to 2.2 mm) were placed in the anterior paramedian area of the palate of each patient. The coil springs of the device were activated to deliver a force of 240 cN per side. The dental and skeletal effects were investigated on pre- and posttreatment cephalometric radiographs.The distal screw produced a Class I occlusion of the first molars by moving them distally 4.7 mm, which is more than conventional appliances can accomplish. Although this took longer than conventional devices (9.1 months), it had the advantage of a roughly 2.1-mm premolar distal movement (ie, no anchorage loss as with traditional techniques).The distal screw anchored by two palatal mini-implants allows not only translatory molar distal movement, but also distal movement of the maxillary first premolars, thereby avoiding characteristic anchorage loss
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Visual Accessibility and Inclusion. An Exploratory Study to Understand Visual Accessibility in the Built Environment.
No full textCurrent research shows that visual accessibility assessment in the built environment typically considers objectively measurable parameters. However, considering subjective visual perception for architectural characteristics is extremely important. Visual perception can vary depending on environmental factors and personal factors and is particularly relevant for people with low to mild visual impairments. This explorative research studied the current state of the art of tools and systems that support the assessment of visual accessibility and investigated new ways of experiencing visual accessibility in the built environment. After identifying gaps in the current scenario, the Cambridge simulation glasses were selected as a tool to simulate visual impairments and therefore experience visual accessibility in the built environment. A pilot study was conducted by navigating a publicly accessible building and experiencing how clearly visible certain architectural characteristics were, while walking with and without wearing the glasses. The goal of this study was to understand their potential use in different settings and explore how to offer an empathic experience of visual accessibility with a low-cost tool for different stakeholders
Efficacy and safety of cytarabine-based regimens for mobilization of peripheral blood stem cells in multiple myeloma
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Long-term follow-up of advanced-stage low-grade lymphoma patients treated upfront with high-dose sequential chemotherapy and autograft
No full textLong-term outcome, after first line intensified high-dose sequential (i-HDS) chemotherapy, was evaluated in 46 patients, aged < or =65 years, with advanced low-grade lymphoma. Seventeen patients had small lymphocytic lymphoma (SLL), 29 had follicular lymphoma (FL), 10 of them with histologic transformation. I-HDS included: (1) tumor debulking, by 2 APO+2 DHAP courses; (2) sequential administration of high-dose (hd) etoposide, methotrexate, and cyclophosphamide, followed by peripheral blood progenitor cell (PBPC) harvest; (3) hd-mitoxantrone + melphalan with PBPC autograft. Ten FL patients had their PBPC immunologically purged ex vivo. There were two treatment-related deaths; five FL patients had short-lasting response followed by disease progression, five SLL reached a stable PR; overall, 34 patients (74%) reached CR. At a median follow-up of 4.3 years, the estimated 9-year OS and EFS were 84% and 45%, respectively. No significant differences were observed in the OS among patients at low, intermediate or high IPI score, with an estimated OS projection of 95%, 78%, and 75%, respectively. FL had longer survival without evidence of residual disease (9-year EFS: 59%) as compared to SLL patients (8.8-year EFS: 17%); however, both groups had prolonged survival and no need of salvage treatment, as shown by the time to disease progression curve, projected to 66% and 62% for SLL and FL, respectively. The results indicate that hd-approach in low-grade lymphoma: (1) is associated with longer progression-free survival as compared to conventional therapies; (2) may imply higher tumor mass reduction in FL as compared to SLL patients; (3) offers long life expectancy, with potential survival benefits at least for patients at intermediate/high IPI score
Graft-Versus-Lymphoma Effect in Relapsed Peripheral T-Cell Non-Hodgkin's Lymphomas After Reduced-Intensity Conditioning Followed by Allogeneic Transplantation of Hematopoietic Cells.
No full textRIC followed by allogeneic stem-cell transplantation is feasible, has a low treatment-related mortality, and seems to be a promising salvage treatment for relapsed PTCL. These findings suggest that the existence of a graft-versus-T-cell lymphoma effec
Overweight as a poor prognostic factor in non-Hodgkin's lymphoma patients undergoing high-dose chemotherapy and autograft.
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