1,721,147 research outputs found
Synthesis of fluorinated analogues of acyclic nucleosides as potential antiviral agents
No full textIn the search for more effective antiviralagentsnucleosides and nucleosideanalogues have been explored extensively.
We report the synthesis of a number of acyclicanalogues of guanosine, adenosine, and uridine fluorinated at different sites of the acyclic moiety.
All compounds have been obtained in optically pure form by condensing chloromethyl 1,3-disubstituted-2-propyl ethers, chloromethyl 1,3-disubstituted-2-butyl ethers, and 1-chloroethyl 1,3-disubstituted-2-propyl ethers with the desired bases.
Open chain fluoroalcohols, needed as starting materials, have been made available by elaborating homochiral fluorinated β-ketosulphoxides.
Difluorinated molecules were obtained by DAST treatment of sulphoxide intermediates.
In the nucleosideanalogues one or two fluorine atoms are present at the positions corresponding to the 3′ and 5′ carbon atoms of the sugar molecule
PREPARATION OF ENANTIOMERICALLY PURE BUTENOLIDES - 4-HYDROXYMETHYL BUTYROLACTONE DERIVATIVES FROM (+)-(R)-3-(4-METHYLPHENYL)SULPHINYLPROPIONIC ACID
No full textOptically pure and fluoro substituted acyclovir analogues
No full text1′,2′-Seco-2′-nor-nucleosides carrying a fluorine atom, instead of hydroxyl group, on C-3′ are synthesized in enantiomerically pure form, starting from (2S)-1-fluoro-3-(R)-[(4-methylphenyl)sulfinyl]-2-propanol.
The nucleosides , were synthesized in enantiomerically pure form starting from (2S,RS)-
Synhtesis of enantiomerically pure 1',2'-seco-nucleosides and 1',2'-seco-2'-nor-nucleosides carrying fluorine and sulfur substituents
No full textEleven title nucleosides (6a-f, 8a-c, 11a,b) having the same chirality of natural products at the carbon mimiking C-4' and carrying a purine or pyrimidine base have been synthesized
Synthesis of Both Enantiomers of Optically Pure Saturated and alpha, beta - Unsaturated gamma-Substituted gamma-Lactones from Chiral Sulphoxides. X-Ray Molecular Structure of (3R,4S)-4-Methyl-4-t-Butyl-3-(p-tolylthio)butanolide and of (3R,4R)-4-(Cyclohex-1-enyl)-4-Methyl-3-(p-tolylthio) butanolide
No full textHomochiral 2,5-disubstituted 3-fluorotetrahydrofurans carrying differently functionalized ring appendages
No full textWith (R)-1-sulphinyl-3-fluoropropan-2-one (1) as starting material a multistep approach is described for the asymmetric synthesis of various 3-fluorotetrahydrofurans of type (7)–(12) which carry differently functionalized 2- and 5-methyl groups
Electron impact mass spectrometry of hemiterpenoid tricyclic quinoline alkaloids
No full textThe mass spectral behaviour of some quinoline-type alkaloids, 3,4-dihydro-2H,5H-pyrano[3,2-c]quinolin-5-ones, isomeric 3,4-dihydro-2H,5H-pyrano[2,3-b]quinolin-5-ones and 2H,5H-pyrano[3,2-c]quinolin-5-ones, was studied in detail with the aid of linked scans, exact mass measurements and collisional spectrometry. The occurrence of a partial isomerization of the differently annulated isomers to a common, open-chain structure is discussed
Synthesis of both enantiomers of optically pure saturated and alpha,beta-unsaturated gamma-substituted gamma-lactones from chiral sulfoxides - X-ray molecular-structure of (3R,4S)-4-methyl-4-tert-butyl-3-(para-tolylthio)butanolide and of (3R,4R)-4-(cyclohex-1-enyl)-4-methyl-3-(paraA-tolylthio)butanolidel
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