89 research outputs found
Role of mitochondrial DNA in longevity, aging and age-related diseases in humans: A reappraisal
No full textThe genetic variability of H. sapiens mitochondrial DNA (mtDNA) can be either germ-line inherited or somatically acquired, and its effect on aging and longevity as well as on the pathogenesis of complex age related diseases is a hot topic. Here we illustrate the complexity of such studies, related to the large genetic variability of mtDNA in different populations and the fact that the rate of the aging process is different in different cells, tissues and organs. As far as concern Alzheimer's disease, the accumulation of somatic mutations in several tissues have been investigated, as well as the inherited mtDNA variability. However, the issue is still controversial and further studies are needed to clarify the role of mtDNA variants in Alzheimer's disease. This review is aimed to summarize the most recent advances in this field. By high throughput mtDNA sequencing and the study of large cohorts of ethnically homogeneous subjects/patients, it is now possible to perform high dimensionality studies in order to clarify the genetic associations among several inherited mtDNA variants and longevity or age-associated diseases in humans
Proceedings of the PERFECT-IGRDM Workshop, 15 April 2005, Arcachon (France)
No full textThe first PERFECT open workshop was organised by F. Sevini as leader of the Users Group, and P. Pareige, local chairman of IGRDM conference (International Group for Radiation Damage Mechanisms in Reactor Pressure Vessel Steels).
The presentations showed the progress accomplished by PERFECT in the areas of Physical modelling, construction of fracture toughness module and advanced integration of the modules. Expectations at the end of the project are high, but PERFECT is organised to continuously monitor the progress, and have a detailed list of deliverables.
It is a long-term project which should continue also beyond the contractual duration of 4 years. For this, collaboration amongst scientist and the feed-back from utilities are crucial. Since the start of the project a considerable acceleration of modelling improvements is in progress, and conclusions stressed that researchers in EU and other countries like Japan, USA and Russian Federation should take the opportunity to join the work programme.JRC.F.4 - Nuclear design safet
Development and transferability of grape EST-SSR markers suitable for mapping in Vitis spp.
No full textComparative analysis of genetic linkage maps and QTL information produced for grape (Vitis spp.)
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Association studies on human mitochondrial DNA: Methodological aspects and results in the most common age-related diseases.
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