799 research outputs found
Value of ER-D5 immunocytochemical determination in routine tissue sections of human breast cancer
No full text ER-D5 is a recently identified protein related to estrogen receptors (ER). Generally ER measurement requires fresh frozen tissue and for ER-D5 assay ethanol (E) fixation of the specimen is recommended. We evaluated the possibility of immunocytochemical detection of ER-D5 in routine formalin-fixed (F) sections in 51 breast cancers comparing the results with those obtained in the same specimens using E as fixative. The results of ER-D5 assay were expressed by the staining index (SI) taking values ≥5 as positive. In all tumors ER was also assayed by a biochemical method (DCCA). The sensitivity of ER-D5 detection in F was only 33.3%, while the specificity was 94.4%. A lower cut-off value of SI for F sections (≥2) increased the sensitivity to 66.6%, leaving the specificity unchanged. A strong correlation was found between the SI of ER-D5 in E and F (p<0.001). The SI of ER-D5 in F sections was also well correlated with ER concentrations (p<0.001). These results suggest that immunocytochemical determination of ER-D5 in routine sections may be useful in retrospective studies of hormone dependence in breast cancer. </jats:p
Il prezzo dei quadri nel mercato fiorentino del Sei e Settecento
No full textThis paper focuses on the price of paintings between the seventeenth and eighteenth century Florence art market, through the setting up of a database of over 520 data on prices between 1629 and 1715, based on the analysis of the paintings’ purchases of by three leading Florentine noble households, the Gerini, the Riccardi and the Salviati. Despite the extensive body of data on price of paintings, incomes of artists, markets and sales techniques of artworks in the main Italian and European cities in the early modern times carried out by scholars of various social studies’s branches in the last years, the issue of price of paintings and works of art is still an enigmatic and controversial subject. The reason is twofold: firstly the analyses of paintings’ prices are considered outside the context of the overall economy of the time and, and secondly, the empirical analysis is inevitably based for the uniformity and comparability of data on the prices of the primary market: the direct commission. This study aims to fill this gap and above all answer to the question raised by the subject of the meeting: what was the price and value of paintings in the in the overall economy at the time? The research considers the price of paintings in the context of the overall economy of the age (from salaries to prices of wheat), in order to identify their real value, proposing, finally, comparisons with the data on the price of paintings in some of the principal art markets of that period, such as Amsterdam, Rome and Venice, and, therefore with other sources of data collections
Application of the proposed IUCN National Red List categories to the terrestrial Vertebrates of Italy.
No full textRecensione di F. Bertini, Feudalità e servizio del Principe nella Toscana del Cinquecento. Federigo Barbolani di Montauto, governatore di Siena, Siena, Cantagalli, 1996
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Expression of calcitonin gene-related peptide in medullary thyroid cancer
No full textWe studied the expression of calcitonin (CT) and calcitonin gene-related peptide (CGRP) in 18 patients with medullary thyroid cancer (MTC) in the neoplastic (primary or metastatic) tissue by immunohistochemistry and in the plasma by radioimmunoassay. CT immunoreactivity was found in 100% of the primary and metastatic MTC, CGRP was expressed in 66% of the primary tumors and in 73% of the metastases. Both the number of positive cells and the degree of staining were always higher for CT than for CGRP staining. While plasma CT concentrations were always increased in patients with metastases, 3 patients with metastases had undetectable plasma CGRP levels. A positive correlation was found between plasma CT and CGRP levels. These data indicate that CGRP is frequently expressed in MTC sections and that plasma CGRP measurement is an additional marker for MTC, although has no advantage with respect to CT measurements in monitoring the progression of the disease
Slow radioactive saliva transit through the esophagus mimicking a mediastinal thyroid mass in a patient with myasthenia gravis
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