2,528 research outputs found
Postfazione
No full textPostfazione che riprende un intervento inedito pronunciato a Tursi con l'occasione di una giornata di studi dedicata ad Albino Pierro
An amino acids mixture improves the hepatotoxicity induced by acetaminophen in mice
No full textAcetaminophen (APAP) is a widely used analgesic and antipyretic drug, but at high dose it leads to undesirable side effects, such as hepatotoxicity and nephrotoxicity. The aim of this study was to evaluate the protective role of DDM-GSH, a mixture of L-cysteine, L-methionine, and L-serine in a weight ratio of 2 : 1 : 1, in comparison to N-acetylcysteine (NAC), against acetaminophen- (APAP-) induced hepatotoxicity in mice. Toxicity was induced in mice by the intraperitoneal (ip) administration of low dose (2 mmol/kg) or high dose (8 mmol/kg) of APAP. DDM-GSH (0.4 to 1.6 mmol/kg) was given ip to mice 1 h before the APAP administration. The same was done with NAC (0.9 to 3.6 mmol/kg), the standard antidote of APAP toxicity. Mice were sacrificed 8 h after the APAP injection to determine liver weight, serum alanine aminotransferase (ALT), and total glutathione (GSH) depletion and malondialdehyde (MDA) accumulation in liver tissues. DDM-GSH improved mouse survival rates better than NAC against a high dose of APAP. Moreover, DDM-GSH significantly reduced in a dose-dependent manner not only APAP-induced increases of ALT but also APAP-induced hepatic GSH depletion and MDA accumulation. Our results suggest that DDM-GSH may be more potent than NAC in protecting the liver from APAP-induced liver injury
A Ginkgo biloba-derived PAF-antagonist-based product
No full textPolymorphous light eruption (PLE) is the most common photodermatosis, with a prevalence as high as 10-20% in Western Europe and the USA. Although not life-threatening, it can severely impair the quality of life, in particular during leisure activities and in outdoors workers.
PLE is a form of idiopathic photodermatoses whose etiopathogenesis, triggered by UV radiation exposure, is presumably immunological. PLE is characterized clinically by the occurrence of non-scarring, pruritic, erythematous papules, vesicles or plaques mainly on sunexposed skin areas. The aim of the study was to verify, against placebo, the anti-PLE action of an orally given innovative, mainly PAF-antagonist, Ginkgo bilobaderived product (GbDP) in substitution of the commonly
used oral anti-histamines and topical corticosteroids.
Differently from placebo, patients treated with a sunscreen along with GbDP showed a clear reduction of PLE symptoms, despite the fact that neither anti-histamines nor topical or oral corticosteroids were used. Out of 240 total episodes expected, the PLE episodes were found to be 18 in the treated group and 218 in the placebo group.
Compliance and tolerability were very good and no relevant side effects occurred in either group. The data suggest a primary role played by GbDP in the etiopathogenesis of PLE and the possible chance offered by the use of the PAF-antagonists in treating PLE
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