203 research outputs found
Notes on the clinical and ragiological aspects of persistent urinary tract infection in 178 children (Infezioni persistenti delle vie urinarie in età pediatrica. Considerazioni sugli aspetti clinici e radiologici)
No full textEffect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis.
No full textPediatr Nephrol. 2007 May;22(5):727-33. Epub 2007 Feb 3.
Effect of carnitine supplementation on lipid profile and anemia in children on chronic dialysis.
Verrina E, Caruso U, Calevo MG, Emma F, Sorino P, De Palo T, Lavoratti G, Turrini Dertenois L, Cassanello M, Cerone R, Perfumo F; Italian Registry of Pediatric Chronic Dialysis.
Abstract
We prospectively evaluated the effects of L-carnitine supplementation on plasma free carnitine (FC) levels, serum lipid profile, and erythropoietin (rhEPO) requirement in 24 children treated with peritoneal dialysis (PD; n=16) or hemodialysis (HD; n=8). The study was divided into a 3-month observation period, and a 3-month treatment period during which patients received 20 mg/kg per day of L-carnitine given orally. Clinical, biochemical, and hematological data were collected every 3 months. FC levels were measured in plasma and peritoneal dialysate by tandem mass spectrometry. There were no statistically significant changes in lipid levels, hemoglobin, or rhEPO requirements during the course of the study. Fifteen patients (13 PD, 2 HD) had plasma FC levels measured before and after treatment; FC levels increased from 32.1 +/- 14.1 micromol/l to 80.9 +/- 38.7 micromol/l (P<0.001). In PD patients, dialysate FC losses increased from 106 +/- 78 micromol/day at baseline to 178 +/- 119 micromol/day after supplementation. Positive correlations between FC plasma levels and dialysate levels (R=0.507) or daily excretion (R=0.603) were found after treatment. In our case series, an oral dose of 20 mg/kg per day of L-carnitine restored FC levels and produced a positive carnitine balance with no significant effects on hematological parameters or lipid profile over a 3-month period. Prolonged treatment duration may be required to obtain significant results
A non-cytotoxic T cell clone from a human kidney graft infiltrate inhibits factor VIII synthesis by donor kidney endothelial cells.
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Permeability plasma factors in nephrotic syndrome: more than one factor, more than one inhibitor.
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Inhibition of factor VIII synthesis by kidney endothelial cells by graft-infiltrating T helper lymphocytes.
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