585 research outputs found
Papaleo F., Il culto micaelico nella Provincia di Salerno. La Grotta dell’Angelo di Pertosa Auletta, Lagonegro 2020
No full textPapaleo F., La frequentazione della cavità in età medievale, in Larocca F. (a cura di), “Tra Pietra e Acqua: Archeologia delle Grotte di Pertosa-Auletta. Studi e ricerche 2004-2016”., Bari 2017, pp. 154-167
No full textL’esplorazione della cavità ha portato alla luce un contesto unico nel suo genere che ha arricchito, sin dalle prime esplorazioni, le conoscenze sulla frequentazione umana della grotta in età preistorica e classica. Nonostante l’esiguità di evidenze materiali, tale frequentazione si estese anche per tutto l’arco del Medioevo, durante il quale la grotta acquisì l’intitolazione all’Arcangelo Michele, prendendo il nome di Crypta Sancti Angeli . A causa dell’esiguità dei manufatti ceramici e dell’assenza di strutture in alzato, “l’esplorazione” della grotta medievale è stata effettuata mediante un’attenta analisi dei fondi pergamenacei e delle fonti bibliografiche ottocentesche relativi all’antico pagus di Pertusia e alla sua Spelunca . In particolare le ricerche si sono concentrate presso la Biblioteca della Badia di Cava de’ Tirreni, gli Archivi di Stato di Napoli e Salerno, le biblioteche e gli archivi comunali e parrocchiali di Caggiano, Polla e Sala Consilina. L’analisi delle fonti ha permesso di ricostruire la storia economico-religiosa delle Grotte di Pertosa tra l’XI e il XIV secolo. Dal punto di vista economico, la cavità si presenta, pertanto, come il centro propulsore dell’economia rurale dell’antica Pertosa e della sua comunità monastica, divenendo parte di svariate donazioni fatte da privati a favore dei Benedettini di Cava de’ Tirreni. La sua frequentazione, inoltre, si caratterizza per avere una forte componente religiosa, che si manifesta in questo periodo nell’erezione dell’ara di San Michele e nella trasformazione della grotta in meta di pellegrinaggio. Appare evidente una forte continuità cultuale, che rende questa cavità fondamentale per la comprensione del passaggio dai culti pagani al culto micaelico
Papaleo F., Il culto micaelico nella Valle del Tanagro (SA): caratteristiche e peculiarità della cristianità nelle aree interne, in Rassegna Storica Salernitana, n. 77, giugno 2022, pp. 35-66.
No full textThe Michaelic cult, originally from Asia Minor, landed in the West following the Greek-Gothic war and the Byzantine conquest of southern Italy. The first theophanic sanctuary linked to the Archangel was born in Apulia, in Monte Sant'Angelo, in the 5th century AD. Following the conquest of the Gargano by the Lombards, the veneration of the Archangel spread to all the territories they occupied, in particular in the so-called Langobardia Minor. Between the 8th and 9th centuries southern Italy - and, more specifically, Molise and Campania - was affected by a widespread diffusion of sanctuaries connected to the Michaelic cult. In fact only 34 of the attested rupestrian churches in Campania have a cultic structures or preserve the title to the Archangel in the toponymic indication. Particularly affected by this phenomenon are the Alburni Mountains and the Tanagro Valley. The Michaelic cult in the ancient Vallis Rationis is characterised by being permeated by a strong duality, which manifests itself in the tradition of a double typology of foundation: Byzantine and Lombard. Actually, within such a circumscribed and peripheral territory, which has always been a melting pot of peoples and cultures thanks to its strategic position, the devotion to the Archangel Michael takes on peculiar characteristics, witnessing itself as the product of the coexistence of different communities, uses and customs, source of new traditions and new forms of worship. Therefore, the Archangel venerated in the Tanagro Valley presents, at the same time, the characteristics of the Byzantine physician and of the Lombard difensor dei. So the Michaelic cult is substantiated in a perfect fusion - not without strong elements of originality - of the two "canonical" traditions. This fusion is manifested by the rurality of the territory in which the cult is established, thanks to the distance from the main urban centres of the region and the dogmatic conformity of their cultic expressions
Papaleo F., Sacred Caves in the Mediterranean. The spread of the cult of Saint Michael between East and West, in Didonna F., Maurano F. (Eds), SPELEOMEDIT. Mediterranean Speleology. Panoramic view of caves and karst of Mediterranean countries, Bologna 2021, pp. 37-40.
No full textPapaleo F., Digital Humanities: una proposta di valorizzazione per il Museo Archeologico Provinciale della Lucania Occidentale, in Cipriani M., Greco E., Pontrandolfo A., Scafuro M. (a cura di), “Dialoghi sull’Archeologia della Magna Grecia e del Mediterraneo. Rassegna annuale di studi, ricerche e notizie di scoperte promossa dalla Fondazione Paestum”, Atti del III Convegno Internazionale di Studi, Paestum 16-18 Novembre 2018, Salerno 2019, pp. 167-176.
No full textThe Archeological Museum situated inside the monumental Chartusia of San Lorenzo, in Padula (SA) is an important institution and its exposition provides essential information about the history of a whole area: the Vallo di Diano. Because of its important frame, this little Museum sees its entries depending on those of the Chartusia. This work intends to propose innovative solutions to refresh the image of the MAPLO, thanks to the help of ICT and the use of multimedial content in free sharing
An operant intra-/extra-dimensional set-shift task for mice
No full textAlterations in executive control and cognitive flexibility, such as attentional set-shifting abilities, are core features of several neuropsychiatric diseases. The most widely used neuropsychological tests for the evaluation of attentional set-shifting in human subjects are the Wisconsin Card Sorting Test (WCST) and the CANTAB Intra-/Extra-dimensional set shift task (ID/ED). These tasks have proven clinical relevance and have been modified and successfully adapted for research in animal models. However, currently available tasks for rodents present several limitations, mainly due to their manual-based testing procedures, which are hampering translational advances in psychiatric medicine. To overcome these limitations and to better mimic the original version in primates, we present the development of a novel operant-based two- chamber ID/ED “Operon” task for rodents. We demonstrated the effectiveness of this novel task to measure different facets of cognitive flexibility in mice including attentional set formation and shifting, and reversal learning. Moreover, we show the high flexibility of this task in which three different perceptual dimensions can be manipulated with a high number of stimuli cues for each dimension. This novel ID/ED Operon task can be an effective preclinical tool for drug testing and/or large genetic screening relevant to the study of executive dysfunction and cognitive symptoms found in psychiatric disorders
Social Neuroscience : Rats Can Be Considerate to Others
No full textAre rats willing to avoid causing suffering in other rats? A new study shows that rats might change their behaviour if it is harmful to others
MIR7–3HG, a MYC-dependent modulator of cell proliferation, inhibits autophagy by a regulatory loop involving AMBRA1
No full textMacroautophagy/autophagy is a tightly regulated intracellular catabolic pathway involving the lysosomal degradation of cytoplasmic organelles and proteins to be recycled into metabolic precursors. AMBRA1 (autophagy and Beclin 1 regulator 1) has a central role in the autophagy signaling network; it acts upstream of MTORC1-dependent autophagy by stabilizing the kinase ULK1 (unc-51 like autophagy activating kinase 1) and by favoring autophagosome core complex formation. AMBRA1 also regulates the cell cycle by modulating the activity of the phosphatase PPP2/PP2A (protein phosphatase 2) and degradation of MYC. Of note, post-transcriptional regulation mediated by noncoding microRNAs (MIRNAs) contributes significantly to control autophagy. Here we describe a new role for the microRNA MIR7-3HG/MIR-7 as a potent autophagy inhibitor. Indeed, MIR7-3HG targets the 30 untranslated region (UTR) of AMBRA1 mRNA, inducing a decrease of both AMBRA1 mRNA and protein levels, and thus causing a block in autophagy. Furthermore, MIR7-3HG, through AMBRA1 downregulation, prevents MYC dephosphorylation, establishing a positive feedback for its own transcription. These data suggest a new and interesting role of MIR7-3HG as an anti-autophagic MIRNA that may affect oncogenesis through the regulation of the tumor suppressor AMBRA1
Acute administration of Urb597 fatty acid amide hydrolase inhibitor prevents attentional impairments by distractors in adolescent mice
No full textThe maturation of attentional control during adolescence might influence later functional outcome or predisposition to psychiatric disorders. During adolescence, the cannabinoid system is particularly sensitive to pharmacological challenges, with potential impact on cognitive functions. Here, we used a recently validated five-choice serial reaction time task protocol to test adolescent C57BL/6J mice. We showed that the pharmacological inhibition (by URB597) of the fatty acid amide hydrolase (FAAH), the major enzyme implicated in anandamide degradation, prevented cognitive disruptions induced by distracting cues in adolescent mice. In particular, these protective effects were indicated by increased accuracy and correct responses and decreased premature responses selectively in the distractor trials. Notably, at the relatively low dose used, we detected no effects in other cognitive, motor, or incentive measures nor long-lasting or rebound effects of FAAH inhibition in cognitive functions. Overall, these data provide initial evidence of selective procognitive effects of FAAH inhibition in measures of attentional control in adolescent mice
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