1,721,239 research outputs found
Ripristino delle possibilità vocali nel laringectomatizzato con protesi tracheoesofagea
No full textThe experience reported concerning vocal rehabilitation employing tracheoesophageal prostheses (TEP) in laryngectomized subjects at the University of Milan is based upon 149 patients who underwent procedures for total laryngectomy from November 1986 on in nearly all cases (137), a primary procedure was followed in order to insert a Blom Singer prosthesis. Some technical modifications in creating the fistula during the reconstruction phase of laryngectomy reduced the number of postoperative and local complications of the fistula. The men phoniatric rehabilitation time is 38 days from the procedure. The most important aspects affecting the length of rehabilitation are the presence of lower respiratory tract disorders and contemporaneous postoperative radiotherapy. The mean lifetime of the prostheses is 92 days, the main restricting factor being the care taken by the patient. Microbiological studies showed the virtually constant association between fungi and Pseudomonas sp. Nevertheless, infection of the fistula and forced removal of the prosthesis occurred only in 1 patient. Other complications were as follows: granulation tissue at the tracheal side of the fistula into the trachea or oesophagus, 6 and 1 respectively; enlargement of the fistula, 5; others, 15. Fifteen percent of the patients does not succeed in achieving a tracheoesophageal voice because of respiratory insufficiency, difficult neuromuscular control or psychological problems
Recettori per l'istamina nel SNC : ruolo nella terapia dei disturbi dell'equilibrio = Histamine receptors in the central nervous system (CNS) : Role in the therapy of equillibrium disorders
No full textThree types of histamine receptors (H1, H2, H3) can be identified in the central nervous system (CNS) as in other apparatus. These act as mediators of the numerous histological and neuro-modulators processes for vascular and digestive phenomena. Over the past few years the role of histamine as a neurotransmitter at the level of CNS has been more clearly defined following the identification of histaminergic nervous pathway and specific receptors for this substance also present on non-histaminergic neurons. In particular; the recent identification of H3 receptors able to modulate the release of histamine and other neurotransmitter at synaptic level, throws new light on our understanding of the mechanisms of action of some drugs, such as betahistine, a molecule with a high level of H3 antagonist activity. This review aims to examine in detail the characteristics of histamine receptors in the CNS and in particular their role in the treatment of balance disorders
L'impiego di colla di fibrina autologa nel trattamento della malattia di Rendu-Osler a localizzazione nasale
No full text
Otoakustische emissionen bei normalhorenden diabetikern = Otoacoustic emissions in diabetic patients with normal hearing
No full textINTRODUCTION:
Transitorily evoked otoacoustic emissions (TEOAE) are a recognised clinical tool for neonatal screening. TEOAE also provide evidence of subclinical cochlear damage in diabetic patients.
METHOD:
TEOAE of 60 patients with well managed diabetes (IDDM) and normal hearing (no value worse than 20 dB (SD 3.943 dB), normal ABR) were compared with TEOAE of 58 normally hearing controls of the same age.
RESULTS:
IDDM patients had a mean response of 7.13 dB (SD 3.943 dB), while the control group had a response of 11.56 dB (SD 4.402 dB).
DISCUSSION:
Significantly worse TEOAE scores were demonstrated in the diabetic patients who had normal hearing, as demonstrated on puretone audiometry. This would suggest that hair-cell damage may occur in the diabetic patient even though hearing loss is not demonstrated
Esthesioneuroblastoma : a general review of the cases published since the discovery of the tumour in 1924
No full textEsthesioneuroblastoma (ENB) arises from the neuroepithelium in the olfactory rim of the nasal cavity. It accounts for about 3% of all intranasal tumours. Reviews since the first description by Berger and Luc in 1924 never reported more than a hundred cases, stressing the rarity of the tumour. However, a thorough literature review revealed a total of 945 reported cases. In our search we found a total of 1,457 cases chronicled in the literature of which perhaps 487 were cited in more than one paper, bringing the total of reported cases to 945. Author cases accounted for 198 and therefore collaborative efforts accounted for 747 cases. Sex distribution was 53.36% male and 46.64% female. Kadish classification was applied to 553 cases revealing 103 (18.29%) class A cases, 182 (32.33%) class B and 278 (49.38%) class C cases. This distribution was generally stable through the decades. Treatment could be classified in 898 cases. It consisted of surgery alone in 25.17% (226 cases), radiotherapy alone in 18.37% (165 cases), combined surgery and radiotherapy in 43.21% (388 cases) and chemotherapy in 13.2% (119 cases), followed in 11 cases (1.22%) by bone marrow transplant. In the reported cases an overall follow up could be evaluated in 477 cases, while in only 234 cases a five-year follow up was done. The outcome was 68.38% alive and disease free, 12.82% alive with disease and 18.80% dead. From these 20.51% had surgery only, 11.11% radiotherapy and 68.38% combined surgery and radiotherapy. The best survival rates were obtained by combined therapy (72.5% vs. 62.5% surgery alone and 53.85% radiotherapy alone). Death rates were highest after radiotherapy alone (30.77% versus 18.75% in combined therapy and 12.50% after surgery alone). In conclusion, ENB is a rare but not exceptional tumour. It is best treated with combined surgery and radiotherapy. Unfortunately early diagnosis is still uncommon and no significant changes to the proportions of Kadish classes at first diagnosis have been noted in recent decades. A greater awareness of the tumour and earlier diagnosis seems the major focus for future research
Carcinoma of the vocal cord. Results after subperichondral cordectomy
No full textThe clinical outcome of 110 patients operated upon by subperichondral cordectomy between 1982 and 1992 for T1s/T1a, NO, MO carcinomas of the vocal cord has been evaluated in this longitudinal epidemiological study. Patients have been followed up until the end of 1993 by examinations done once a month (first year), every three months (years 2 to 4), every six months (years 5 to 8), and then once a year. Life-tables have been computed according to Kaplan and Meier and raw survival has been 90.0%. Considering only the mortality due to any type of neoplastic disease, the survival reached 93.6%. Finally, considering only deaths due to recurrences or metastases of the primary tumor, the survival rate was 95.5%. Mortality after the first recurrence was 27.3%, after a second recurrence 50.0%. A correlation between number of cigarettes smoked and the risk of recurrence of the tumor could be observed (p < 0.01), while gross appearance and histologic grading of the vocal cord carcinoma proved to be uncorrelated with the risk of recurrences
Vocalization related stapedius muscle activity in different age chickens (Gallus gallus) and its role in vocal development
No full textGestione delle prove di inoculazione sperimentale ai fini del Regolamento n.2073/2005/Ce (I parte).
No full textPrima pubblicazione in Italia che individua possibili linee guida per impostare correttamente una prova di inoculazione sperimentale di microganismi patogeni (challenge test) in alimenti per l'uomo
- …
