1,721,113 research outputs found

    Conversion of β-sitosterol into both fucosterol and isofucosterol in Tenebrio molitor

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    It has been demonstrated with cold trap experiments that Tenebrio molitor transforms β-sitosterol not only into fucosterol, but also into isofucosterol

    Lights_and_shadows_of_schizophrenia_therapy_research – Supplemental material for Lights and shadows of schizophrenia therapy research: Lessons from oral risperidone and olanzapine

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    Supplemental material, Lights_and_shadows_of_schizophrenia_therapy_research for Lights and shadows of schizophrenia therapy research: Lessons from oral risperidone and olanzapine by Eraldo F Nicotra, Daniele Lecca, Gianluca Casu, Mario Palomba, Annesha Sil and Giorgio Marchese in Journal of Psychopharmacology</p

    Synthesis of the phosphono-analogue of α-D-glucose 1-phosphate

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    The synthesis of 2,6-anhydro-1-deoxy-L-glycero-D-gluco-heptulopyranose-1-phosphonic acid, the phosphono-analogue of α-D-glucose 1-phosphate in which the substitution of a methylene group for an oxygen occurs at the anomeric centre of the sugar, is reported

    Migration of tritium to C-24 during the metabolism of 24-methylene[23,23, 25-3H3]cholesterol by the insect Tenebrio molitor

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    24-Methylene[23,23,25-3H3]cholesterol was transformed by Tenebrio molitor larvae into [23,23,24-3H3]cholesterol; the tritium label distribution in the cholesterol isolated from the larvae compared with that in the administered precursor is in agreement with the migration of hydrogen from C-25 to C-24 during the dealkylation process

    Metabolism of C28 phytosterols in the insect Tenebrio molitor: Migration of the C-25 hydrogen atom to C-24

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    During the conversion of 24-methylenecholesterol into cholesterol by Tenebrio molitor larvae the C-25 hydrogen migrates to the C-24 position

    Role of 24- and 28-hydroxylated intermediates in the metabolism of β-sitosterol in the insect Tenebrio molitor

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    1. [28-3H]Stigmast-5-ene-3 beta, 28-diol and [23,23,25-3H]stigmast-5-ene-3 beta, 24-diol were synthesized. 2. Each of the samples was mixed with beta-[4-14C]sitosterol and administered to Tenebrio molitor larvae. 3. The former compound is not utilized by the insect; the latter, although metabolized to 24(28)-ethylidene sterols and cholesterol, is not a beta-sitosterol metabolite. 4. The above results are discussed in relation to the mechanism of formation of the 24(28)-double bond in beta-sitosterol metabolism in T. molitor
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