959 research outputs found
Henry Lucy and the world of parliamentary journalism, 1872-1916
No full textThis dissertation investigates the changing relationship between parliament and the press in late Victorian and Edwardian Britain. The focus of the study is the life and career of Henry Lucy, widely regarded as the foremost parliamentary journalist of his time."Modern parliamentary reporting developed in the decade which followed the passage of the Reform Act of 1867. The ""new journalism"" of the 1870s paid close attention to parliamentary personalities, and engaged in gossipy descriptions of M. P.'s appearance and manner. In his roles as the chief parliamentary reporter for the Daily News, as well as for Gentleman's Magazine and The World, Henry Lucy played an important role in the creation of this new style. He originated the form of the modern parliamentary sketch, and his model was imitated by numerous rivals. Simultaneously, he became one of the first reporters to frequent the inner lobby of the House of Commons, and he was later recognized as the first important parliamentary ""lobbyist."" The dissertation explains the context and the significance of Lucy's innovations, and relates their development to the changing political world of the late nineteenth century."During his long career Henry Lucy contributed to numerous newspapers and magazines, but he was principally known for his connections with the Daily News (where he served as editor in 1886-87), the Observer, and Punch. He maintained close relations with many of the most important political leaders of his time, including William Ewart Gladstone, Lord Randolph Churchill, Joseph Chamberlain and Lord Rosebery. As author of nearly two dozen books, mainly personal memoirs and parliamentary histories, Lucy was read and appreciated by thousands of contemporaries, and in this form his accounts of political life have influenced generations of historians. He was one of the first working journalists to earn for himself a position in respectable London society, and he was knighted in 1909. He died a wealthy man, with an estate of nearly a quarter of a million pounds. Lucy's career demonstrates the increasing interdependence of the political and journalistic worlds at a time of increasing change in both.Made available in DSpace on 2011-05-07T13:59:49Z (GMT). No. of bitstreams: 2
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Novel deletion variants of 9q13–q21.12 and classical euchromatic variants of 9q12/qh involve deletion, duplication and triplication of large tracts of segmentally duplicated pericentromeric euchromatin
No full textLarge-scale copy number variation that is cytogenetically visible in normal individuals has been described as euchromatic variation but needs to be distinguished from pathogenic euchromatic deletion or duplication. Here, we report eight patients (three families and two individuals) with interstitial deletions of 9q13-q21.12. Fluorescence in situ hybridisation with a large panel of BACs showed that all the deleted clones were from extensive tracts of segmentally duplicated euchromatin, copies of which map to both the long and short arms of chromosome 9. The variety of reasons for which these patients were ascertained, and the phenotypically normal parents, indicates that this is a novel euchromatic variant with no phenotypic effect. Further, four patients with classical euchromatic variants of 9q12/qh or 9p12 were also shown to have duplications or triplications of this segmentally duplicated material common to both 9p and 9q. The cytogenetic boundaries between the segmentally duplicated regions and flanking unique sequences were mapped to 9p13.1 in the short arm (BAC RP11-402N8 at 38.7 Mb) and to 9q21.12 in the long arm (BAC RP11-88I18 at 70.3 Mb). The BACs identified in this study should in future make it possible to differentiate between clinically significant deletions or duplications and euchromatic variants with no established phenotypic consequence
Lessons learnt from large-scale exon re-sequencing of the X chromosome
No full textA candidate gene approach to identifying novel causes of disease is concept-limiting and in the new era of high throughput sequencing there is now no need to restrict the experiment to a few interesting genes. We have recently completed a large-scale exon re-sequencing project using Sanger sequencing technology to analyse approximately 1 Mb of coding sequence of the X chromosome in probands from >200 families with various forms of intellectual disability. We review the lessons learnt from this experience. Comparing large data sets will certainly reveal pathogenic mutations in genes that were not possible to identify previously. However, the task of distinguishing pathogenic mutations from rare sequence variants is not easy and is the most substantial challenge to the next decade. High-throughput technology has the attraction of being cheap, fast and comprehensive but for projects that require detailed coverage of a genomic region at an exhaustive level they may require a combination of large-scale with a small-scale follow-up of difficult regions to sequence. The number of rare truncating variants present in coding regions of the X chromosome that are not pathogenic was 1%. The importance of the quality of the starting material both clinically and molecularly and the number of sequence variants both rare and common that any one individual has across their coding sequence is discussed.F. Lucy Raymond, Annabel Whibley, Michael R. Stratton and Jozef Gecz
Identification and characterization of two novel JARID1C mutations: suggestion of an emerging genotype-phenotype correlation
No full textFirst published online 14 October 2009. © 2010 European Society of Human GeneticsMental retardation (MR) is characterized by cognitive impairment with an IQ A) in a published family with nonsyndromic MR, MRX13. This change occurs in a highly conserved amino acid, with proline (P) being substituted by threonine (T) (p.P554T). [corrected] Functional analysis shows that this amino-acid substitution compromises both tri- and didemethylase activity of the JARID1C protein. We conclude that the two novel changes impair JARID1C protein function and are disease-causing mutations in these families.Sinitdhorn Rujirabanjerd, John Nelson, Patrick S. Tarpey, Anna Hackett, Sarah Edkins, F Lucy Raymond, Charles E. Schwartz, Gillian Turner, Shigeki Iwase, Yang Shi, P. Andrew Futreal, Michael R. Stratton, Jozef Gec
You have heard the songs of roses, violets and other posies of the lily and mignonette
No full text"Lucy Daly sings this song with great success in Ward & Vokes Co." [Cover page]Archived web conten
Mutations in USP9X are associated with X-linked intellectual disability and disrupt neuronal cell migration and growth
No full textData source: Supplemental data, https://doi.org/10.1016/j.ajhg.2014.02.004With a wealth of disease-associated DNA variants being recently reported, the challenges of providing their functional characterization are mounting. Previously, as part of a large systematic resequencing of the X chromosome in 208 unrelated families with nonsyndromic X-linked intellectual disability, we identified three unique variants (two missense and one protein truncating) in USP9X. To assess the functional significance of these variants, we took advantage of the Usp9x knockout mouse we generated. Loss of Usp9x causes reduction in both axonal growth and neuronal cell migration. Although overexpression of wild-type human USP9X rescued these defects, all three USP9X variants failed to rescue axonal growth, caused reduced USP9X protein localization in axonal growth cones, and (in 2/3 variants) failed to rescue neuronal cell migration. Interestingly, in one of these families, the proband was subsequently identified to have a microdeletion encompassing ARID1B, a known ID gene. Given our findings it is plausible that loss of function of both genes contributes to the individual's phenotype. This case highlights the complexity of the interpretations of genetic findings from genome-wide investigations. We also performed proteomics analysis of neurons from both the wild-type and Usp9x knockout embryos and identified disruption of the cytoskeleton as the main underlying consequence of the loss of Usp9x. Detailed clinical assessment of all three families with USP9X variants identified hypotonia and behavioral and morphological defects as common features in addition to ID. Together our data support involvement of all three USP9X variants in ID in these families and provide likely cellular and molecular mechanisms involved.Claire C. Homan, Raman Kumar, Lam Son Nguyen, Eric Haan, F. Lucy Raymond, Fatima Abidi, Martine Raynaud, Charles E. Schwartz, Stephen A. Wood, Jozef Gecz, Lachlan A. Joll
Qualitative Assessment
No full textHealth psychology is a rapidly expanding discipline at the interface of psychology and clinical medicine. This new edition is fully reworked and revised, offering an entirely up-to-date, comprehensive, accessible, one-stop resource for clinical psychologists, mental health professionals and specialists in health-related matters. There are two new editors: Susan Ayers from the University of Sussex and Kenneth Wallston from Vanderbilt University Medical Center. The prestigious editorial team and their international, interdisciplinary cast of authors have reconceptualised their much-acclaimed handbook. The book is now in two parts: part I covers psychological aspects of health and illness, assessments, interventions and healthcare practice. Part II covers medical matters listed in alphabetical order. Among the many new topics added are: diet and health, ethnicity and health, clinical inrterviewing, mood assessment, communicating risk, medical interviewing, diagnostic procedures, organ donation, IVF, MMR, HRT, sleep disorders, skin disorders, depression and anxiety disorders.
ContentsPart I. Psychology and Health and Illness; Part II. Medical Topics.
ContributorsLeif Edvard Aaro, Gail Williamson, David Shaffer, Elaine Leventhal, Angela Liegey Dougall, Stacie Spencer, Andrew Baum, Yael Benyamini, Howard Leventhal, Elaine Leventhal, Julie Turner-Cobb, Richard Boles, Michael Roberts, Margaret Stroebe, Henk Schut, Wolfgang Stroebe, Keith Petrie, Lisa Reynolds, Naomi Lester, Francis Keefe, Meredith Rumble, Jeffrey Labban, Colin Murray Parkes, Yael Benyamini, John Berry, David Sam, Suzanne Scott, Jane Ogden, Timothy Elliott, Laura Dreer, Richard Slatcher, James Pennebaker, Jim Maddux, Jane Ussher, Charles Abraham, Tim Carmody, Rachael Powell, Marie Johnston, Thomas Whelan, Willem Kop, David Krantz, Howard Leventhal, Yael Benyamini, Christina Shafer, Tirrill Harris, Christina Lee, R. Glynn Owens, Staffan Hygge, Dennis Turk,Tasha Burwinkle, Kenneth Wallston, Stephanie Stone, Robert McCrae, Neville Owen, Kym Spathonis, Eva Leslie, Irving Kirsch, Elizabeth Bachen, Sheldon Cohen, Anna Marsland, Christopher Bass, Lena Ring, Karen Kim, Harold Koenig, Baruch Fischhoff, Albert Bandura, Lorraine Sherr, Jason Ellis, Thomas Ashby Wills, Michael Ainette, Lion Shahab, Robert West, Ainsley Hardy, Susan Ayers, Andrew Steptoe, Elizabeth Broadbent, Keith Petrie, Stephen Sutton, Stanislav Kasl, Beth Jones, Erin Bigler, Linda Worrall, Ellen Skinner, Richard Rogers, Peggilee Wupperman, Ray Fitzpatrick, Mark Conner, Brian McMillan, Ann Bowling, Ad Kaptein, Elizabeth Broadbent, Robert Sternberg, Michele Tugade, Tamlin Conner, Lisa Feldman Barrett, Jane Powell, Melissa Lamar, Amir Raz, Nancy Chiaravalloti, Amanda O'Brian, John DeLuca, Sandra Waters, Kim Dixon, Lisa Caitlin Perri, Francis Keefe, Susan Eisen, Angela Liegey Dougall, Felicity Bishop, Lucy Yardley, Ann Bowling, Brian Lakey, Jay Cohen, Gerald Davison, Raymond Gaeta, Carl Noe, Robert Gatchel, Andrew Eagle, Michael Worrell, Deborah Polk, Christie King, Kenneth Heller, Robert Bor, John Allen, Peter Hajek, Gerjo Kok, Michael Heap, Janet Tresure, Esther Maissie, Barbara Wilson, Stephen Morley, Michael Ussher, Jo-anne Carlyle, Jennifer Morse, Charles Reynolds, Michael Bruch, Kathleen Mulligan, Stan Newman, Benjamin Gottlieb, Dianne Kenny, Paul Estabrooks, Russell Glasgow, Rob Horne, Hannah McGee, Katherine Joekes, Christina Maslach, David French, Theresa Marteau, Rudolph Moos, Jeanne Schaefer, Bernice Moos, John Weinman, Robin Fiore, Hugh Barr, Clare Harries, Peter Ayton, Jonathon Silverman, Peter Bower, Nicki Mead, Maria Woloshynowych, Charles Vincent, Ray Fitzpatrick, Valerie Sutherland, Patricia Loft, Geraldine Meechan, Keith Petrie, Anne Miles, Katharine Parkes, Chris McManus, Claus Vogele, Angela Hall, Jane Kidd, Lorraine Noble, Pauline Slade, Robert Frank, Andrea, Lee Stephen Kellett, Michael Sayette, Mary Gregerson, Barbara Wilson, Narinder Kapur, Ronald Melzack, Joel Katz, Kirstie McKenzie-McHarg, Rachel Rowe, Ad Kaptein K. F. Rabe, Amanda C de C Williams, Linda Pring, Sarah Amponsah, Anthony Manstead, Claire Phillips, Alice Simon, Katie Robb, Sharon Manne, Barbara Andersen, Laura Simonelli, Kristen Carpenter, Gerry Humphris, Jennifer Devlen, Janelle Wagner, Ronald Brown, Angela Dougall, Stephen Lepore, Katherine Roberts, Ron Borland, Suzanne Dobbinson, Jan Stygall, Stan Newman, Kevin Browne, Catherine Hamilton-giachritsis, Jeremy Turk, Ruth Cairns, Trudie Chalder, Matthew Speltz, Anna Marsland, Sheldon Cohen, Elizabeth Bachen, Felicity Bishop, George Lewith, Paul Bennett, Beth Alder, Robert Allan, Stephen Scheidt, Christopher Smith, Kathleen Mulligan, Stan Newman, Bob Lewin, Jan Stygall, Stan Newman, Claire Glasscoe, Laurence McKenna, David Scott, Jenny Rusted, Alison Woodcock, Clare Bradley, Irene Frieze, Maureen McHugh, Heather Ashton, Sari Schwartz, David Krantz, Andrew Scholey, Andy Parrott, David Kennedy, Christine Temple, Eric Stice, Heather Shaw, David Horne, Elizabeth Ann Coombes, Eric Storch, Gary Geffken, Martin Herbert, Graham Scambler, Rona Moss-Morris, Meagan Spence, Nichola Rumsey, Peter Hepper, James Dornan, Dan McKenna, P
Green wedges:origins and development in Britain
No full textThe paper analyzes the history of green wedges in Britain from their origins in the first decade of the twentieth century up until the outbreak of the Second World War. Often neglected by the literature in favour of the 'greenbelt', the 'green wedge' was equally at the forefront of the minds of planners debating urban growth and the provision of open spaces for modern cities. Firstly, the paper looks into the origins of the idea, with particular focus on discussions about the integration of park and traffic systems in the period. Secondly, it focuses on the fundamental role that the 1910 RIBA Town Planning Conference played in the emergence of the green wedges idea and in its immediate reception and diffusion. Subsequently, the paper discusses the idea's development after the Conference, predominantly in plans for Greater London and in texts by its main supporters, which included H. V. Lanchester, G. L. Pepler, T. H. Mawson, and P. Abercrombie. © 2013 Taylor & Francis
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