76 research outputs found
A bizarre foreign body in the appendix: A case report
No full textForeign bodies are rare causes of appendicitis and, in most cases, ingested foreign bodies pass through the alimentary tract asymptomatically. However, ingested foreign bodies may sometimes remain silent within the appendix for many years without an inflammatory response. Despite the fact that cases of foreign-body-induced appendicitis have been documented, sharp and pointed objects are more likely to cause perforations and abscesses, and present more rapidly after ingestion. Various materials, such as needles and drill bits, as well as organic matter, such as seeds, have been implicated as causes of acute appendicitis. Clinical presentation can vary from hours to years. Blunt foreign bodies are more likely to remain dormant for longer periods and cause appendicitis through obstruction of the appendiceal lumen. We herein describe a patient presenting with a foreign body in his appendix which had been swallowed 15 years previously. The contrast between the large size of the foreign body, the long clinical history without symptoms and the total absence of any histological inflammation was notable. We suggest that an elective laparoscopic appendectomy should be offered to such patients as a possible management optio
Off-label use of thalidomide for the treatment of a bleeding cutaneous metastasis
No full textWe herein describe the case of a 65-year-old man with frequent hospitalizations for severe anemia due to several recurrent bleedings of a cutaneous metastasis of hepatocellular carcinoma, and its successful off label treatment with thalidomide therapy for controlling bleeding and reducing transfusion requirements
Cavernous transformation of the portal vein associated to multiorgan developmental abnormalities
No full textInitial diagnosis of cavernous transformation of the portal vein
(portal cavernoma) is rarely made in adults. Its main clinical manifestation is
upper gastrointestinal hemorrhage due to variceal bleeding. More rarely,
diagnosis is made from obstructive jaundice. In children, this condition is
frequently associated to prehepatic portal hypertension and congenital
anomalies, the most frequent of which are atrial septal defects or
malformations of the biliary tract or of the inferior vena cava.
We describe here a case of a 23-year-old female presenting with massive
hematemesis due to the presence of esophageal and small intestinal varices.
She had a cavernous transformation of the portal vein with prehepatic portal
hypertension associated with heretofore unreported malformations such as
right pulmonary hypoplasia, cardiac dextroposition, and right renal ectopia.
A unifying hypothesis (e.g. an intrauterine vascular insult) to explain the
pathogenesis of these defects seems unlikely. Appropriate tests failed to
identify specific functional abnormalities in these organs. Although she bled
more than once, the combination of sclerotherapy and b-blockers has been,
thus far, able to control the major clinical consequences of this diseas
Hepatitis C virus infection and gastric lymphoproliferation in patients with Sjogren's syndrome
No full textSafety and efficacy of thromboprophylaxis with fondaparinux in elderly acutely ill medical patients with renal impairment: a retrospective single center study
No full text
Gastric B-Cell clonal expansion and Helicobacter pylori infection in patients with autoimmune diseases and with dyspepsia - A follow-up study
No full textBackground: It is not clear whether gastric B-cell clonal expansion, a possible precursor of mucosa-associated lymphatic tissue (MALT) lymphoma, is exclusively linked to Helicobacter pylori infection and virulence. Methods: In this study we followed up, for up to 33 months, 16 VDJ polymerase chain reaction-positive patients (4 with dyspepsia, 9 with Sjogren's syndrome, and 3 with other autoimmune diseases). Of these, 12 were H. pylori-positive. In addition, in H. pylori-positive patients we tested whether the serum anti- cag-A (a potential marker of virulence) was preferentially associated with B- cell clonality. Results: In all but one patient clonality appeared temporally unrelated to H. pylori infection. The prevalence of anti-cagA was not higher in H. pylori/VDJ-positive patients than in controls. Conclusions: These data indicate that, in addition to H. pylori, gastric B-cell clonality may be sustained by other agents/mechanisms. Anti-cag-A does not appear to be involved in the pathogenesis of clonality
Lymph Node Ratio as a Prognostic Factor in Patients with Pancreatic Endocrine Tumours JOP
No full textSafety of fondaparinux in the prevention of venous thromboembolism in elderly medical patients: results of a single-center, retrospective study
No full textVenous thromboembolism (VTE) is one of the leading causes of morbidity and mortality in acutely ill medical patients. Fondaparinux is recommended for the prevention of VTE in this setting, but little information is available on its safety and effectiveness in unselected, "real world" patients. The aim of this paper was to assess the safety and efficacy of fondaparinux in elderly acutely ill medical patients
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