163 research outputs found
Studio e sviluppo di approcci alternativi per la quantifica di cellule con riarrangiamenti cromosomici non bilanciati: applicabilità nel monitoraggio del "Residual Disesase" nel corso di patologie ematologiche
No full text
FAILURE OF TREATMENT IN CHLDHOOD EXTRACRANIAL AND EXTRATESTICULAR MALIGNANT GERM CELL TUMORS
No full textProceedings of the fifth germ cell tumor Conferenc
Exploring the realm of scaled solar system analogues with HARPS
No full textContext. The assessment of the frequency of planetary systems reproducing the Solar System's architecture is still an open problem. Detailed study of multiplicity and architecture is generally hampered by limitations in quality, temporal extension and observing strategy, causing difficulties in detecting low-mass inner planets in the presence of outer giant planetary bodies.
Aims. We present the results of high-cadence and high-precision HARPS observations on 20 solar-type stars known to host a single long-period giant planet in order to search for additional inner companions and estimate the occurence rate fp of scaled Solar System analogs, i.e. systems featuring lower-mass inner planets in the presence of long-period giant planets.
Methods. We carry out combined fits of our HARPS data with literature radial velocities using differential evolution MCMC to refine the literature orbital solutions and search for additional inner planets. We then derive the survey detection limits to provide preliminary estimates of fp.
Results. We generally find better constrained orbital parameters for the known planets than those found in the literature. While no additional inner planet is detected, we find evidence for previously unreported long-period massive companions in systems HD 50499 and HD 73267. We finally estimate the frequency of inner low mass (10-30 M⊕) planets in the presence of outer giant planets as fp<9.84% for P<150 days.
Our preliminary estimate of fp is significantly lower than the values found in the literature; the lack of inner candidate planets found in our sample can also be seen as evidence corroborating the inward migration formation model for super-Earths and mini-Neptunes. Conclusions. Our results also underline the need for high-cadence and high-precision follow-up observations as the key to precisely determine the occurence of Solar System analogs
LA NUTRIZIONE PARENTERALE E L’INTESTINO RESIDUO: QUALE RELAZIONE NEL DECORSO DI PAZIENTI CON SINDROME DA INTESTINO CORTO? VALUTAZIONE DA UNA CASISTICA NAZIONALE MULTICENTRICA
No full textIn età pediatrica la Sindrome da INtestino Corto (SIC), il più delle volte conseguenza di un intervento chirurgico di resezione intestinale massiva, è la più frequente causa di Insufficienza Intestinale (ID). L'esigenza di conoscere la realtà delle SIC ha promosso uno Studio Nazionale Multicentrico retrospettivo ("SIC 91" ) per valutare i casi di SIC osservati dal 1991 al 2001, avvalendosi inoltre dei dati del Network Italiano "Insufficienza Intestinale in Età Pediatrica". I dati preliminari sono già stati presenatti e pubblicati in altra sede ed hanno permesso di esprimere alcune considerazioni iniziali. Gli obiettivi di questo Studio sono quelli di valutare l'outcome dei pazienti in relazione alla durata della Nutrizione Parenterale
Working memory training increases general learning abilities in CD-1 outbred mice:
No full textGeneral intelligence is a cognitive trait that is purported to influence most domain-specific learning abilities in humans. Like humans, CD-1 outbred mice express individual differences in their "general" cognitive abilities, such that performance across diverse batteries of learning tasks tend to be positively correlated, and this general learning factor accounts for 32-48% of the variance of individual animals performance in cognitive test batteries. It has been demonstrated that in both humans and mice, the efficacy of working memory capacity correlates highly with measures of general cognitive ability. In three experiments, here we demonstrate that in genetically heterogeneous mice, repetitive working memory training promotes an increase in selective attention and has a commensurately positive effect on the animals' aggregate performance on a battery of five learning tasks. The enhancement of general cognitive performance by working memory exercise was attenuated if the selective attention demands of that exercise were reduced. Finally, because much of the human research conducted on working memory training is done in pre-pubescent children, we trained a group of mice beginning in pre-pubescence and found no difference between that group and one trained at our typical young-adult age. In total, these results provide initial evidence that the efficacy of working memory capacity and selective attention are causally related to an animal’s general cognitive performance, and suggest behavioral strategies to promote those abilities.Ph.D.Includes bibliographical references (p. 63-65)by Kenneth Royce Ligh
Identifying reliable traits across laboratory mouse exploration arenas: A meta-analysis
No full textThis study is a meta-analysis of 367 mice from a collection of behaviour neuroscience and behaviour genetic studies run in the same lab in Zurich, Switzerland. We employed correlation-based statistics to confirm and quantify consistencies in behaviour across the testing environments. All 367 mice ran exactly the same behavioural arenas: the light/dark box, the null maze, the open field arena, an emergence task and finally an object exploration task. We analysed consistency of three movement types across those arenas (resting, scanning, progressing), and their relative preference for three zones of the arenas (home, transition, exploration). Results were that 5/6 measures showed strong individual-differences consistency across the tests. Mean inter-arena correlations for these five measures ranged from +.12 to +.53. Unrotated principal component factor analysis (UPCFA) and Cronbach’s alpha measures showed these traits to be reliable and substantial (32-63% of variance across the five arenas). UPCFA loadings then indicate which tasks give the best information about these cross-task traits. One measure (that of time spent in “intermediate” zones) was not reliable across arenas. Conclusions centre on the use of individual differences research and behavioural batteries to revise understandings of what measures in one task predict for behaviour in others. Developing better behaviour measures also makes sound scientific and ethical sense
Creighton University Omaha, Nebraska School of Law Class of 1994
No full textGraduates|Albers, Virginia A.; Alexov, Ann; Allred, Joseph O.; Arnold, Suzanne M.; Atwood, Stetson F.; Austin, Raymond L.; Baer, Christine M.; Baker, John M.; Barrett, Michael S.; Barritt, Lori J.; Beel, Susan N.; Bendorf, Erik C.; Berg, Brett W.; Blankenau, Andrea M.; Bosselman, Brandi K.; Braddy, Thomas M.; Brewer, Thomas K.; Butts, Greg E.; Buzzello, Eileen Reilly; Campbell, Mikki E.; Capp, Michael W.; Carny, Patrick C.; Carrico, Kevin J.; Cassens, Damon D.; Cellilli, Kelley S. (Class Representative); Cellilli, Thomas H., III; Chamberland, Raymond F., III; Christie, Kelly K.; Comcowich, Thomas L.; Connot, Don J.; Conway, Kathryn M.; Cook, Shon A.; Cool, Kenneth J.; Coots, John C.; Cottam, Glenda L.; Courtney, Jeff T.; Cox, Nathan B.; Crews, Joseph J.; Crowl, Ronald D.; Curley, Gregory M.; Dahlquist, William P.; Davis, Elizabeth J.; Degan, Michael S.; Dixon, H. Dale, III; Doughty, Jonathan E.; Dowse, Ronald T.; Endacott, Kent E.; Epstein, Melissa P.; Eret-Triplett, Tammy M.; Erlbacher-Anderson, Amy L.; Erlemeier, Melissa M.; Fairfield, Brian T.; Falcone, Karen M.; Farnan, Annette Walker; Foreman, M. Meg; Galter, Dana M.; Garrison, Gaylord R.; Gary, Corby A.; Geist, Stacey N.; Gerber, Susan R.; Gericke, Anthony J.; Gnabasik, Paul M.; Gradoville, Steven J.; Graeve, Shurie R.; Gray, Willis W.; Grey, Samuel T.; Hauser, Jack C.; Hawk, Camille R.; Heathershaw, Carla K.; Heddings, Raymond E.; Heims, Tracy M.; Hemming, Sarah G.; Hilger, Andrew J.; Holley, Laura A.; Holmstrom, Mark D.; Horan, John L.; Huber, Jeffrey J.; Hunter, Teresa Coleman; Ilg, Shawn M.; Jacoby, Jeffrey J.; Jasper, David F.; Jones, Robert G.; Kassebaum, Karen S.; Kearns, Joseph P.; Kelly, James M.; Kesthely, Louis J., Jr.; Klein, Mark F.; Kline, Lawrence P.; Knapp, Jayne D.; Kolpin, Ryan R.; Kros, Jeffrey J.; Krysh, Raymond D.; Krzewinski, Aaron M.; Lee, Ronald J.; Lewis, Todd R.; Lingelbach, John M.; Loberg, Roberta J.; LoCurto, Lisa A.; Long, Debra A.; Long, Michael L.; Malek, Lori C.; Martin, Stephen R., II; Massih, Melody D.; Masten, Heather A.; Matthews, Michael G.; Matukewicz, Michael J.; McCarty, Kathryn G.; McGill, Maureen E. (President); McGinnis, Jeffrey P.; McGoldrick, Stephen P.; McKinney, Deborah A.; McManaman, Kevin R.; McPhee, Donald P.; Miller, Christine L.; Mitchell, Gene E.; Monday, Michael G.; Moore, Albert A.; Moran, Julie A.; Mulherin, William T.; Murphy, Elizabeth A.; Myers, Eric D.; Nack, Anne T.; Ng, Deborah W. L. M. Q.; Nolan, Kristin M.; O'Connor, Allyn M.; Olszewski, Edward B.; Palmer, James W.; Palzer, Jeffrey T.; Parker, Shaun O.; Pascotto, Tara M.; Peak, Michelle A.; Pearson, Jennifer A.; Peatrowsky, Dennis G.; Pemberton, John L.; Peterson, Thomas M.; Pettygrove, Kay L.; Prenda, Amy Taylor; Purcell, Stephen G.; Rath, Nancy A.; Reid, Todd A.; Rizzo, John J.; Robson, Jeanelle R.; Runge, Patrick R.; Scarlett, Rana A.; Schaffer, William O.; Schelwat, Douglas E.; Schulz, Britany J.; Schwade, Amy S.; Schwartz, Brian D.; Schwartzburt, Mark; Shehan, Suzanne M.; Shirley, Jimmy C.; Silva, Sandra L.; Slater, Elizabeth A.; Slimp, Kevin J.; Smith, Kelli J. (Class Representative); Snyder, Rachel E.; Stewart, Lisa T.; Strait, Scott D.; Sunde, Steven D.; Taylor-Riley, Kimberley R.; Tennies, Steven E.; Tentman, DeVonnia M.; Thorpe, David J.; Thrower, David J.; Touby, L. Michele; Tracy, Thomas J.; Tronson, Stacey C.; Trumler-Myers, Denise D.; Vazquez, Arturo; Vescio, Paul F.; Vila, Francisco A.; Voss, Roberta L.; Wade, Arthur T., III; Wallwey, Dianne R.; Walocha, David M.; Weimer, Todd B.; Welch, Lawrence E., Jr.; Wellendorf, Lisa M.; Werts, Kelly J.; Whelan, Kevin E.; Wolf, Judith A.; Woods, Patricia M.; Wuester, Bert E., Jr.; Wurst, John E.; Harkins, Robert E. (not pictured); Koeneke, Kim A. (not pictured); Stepien, Scott A. (not pictured); Van Wyk, Douglas J. (not pictured); Cole, Darren T. (not pictured)|44 x 37 in. (landscape
"Disney is the Tiffany’s and I am the Woolworth's of the business": A critical re-analysis of the business philosophies, production values and studio practices of animator-producer Paul Houlton Terry
No full textThis thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.Animator-producer Paul Houlton Terry has been portrayed as having little passion for the animation he produced and being more concerned with making a profit than producing entertaining cartoons with high production values. The purpose of the dissertation is to re-evaluate Terry‘s legacy to animated cartooning by analyzing his business philosophies, production values, and studio practices.
Application of four psychodynamic factors to the early life and career of Terry, 1887-1929, found that his economic decision making was characterized by: an external locus of control, risk-averse financial behaviour, extreme saving behaviour through precaution, and shrewd money management practices. Based on Terry‘s historical responses to twelve major economic, technological, or institutional forces of change for the period 1929-1955, the psychodynamic factors were found to provide accurate explanations for his studio practices and production decisions.
There was no evidence to support the conclusion that three early career disappointments undermined Terry‘s intrinsic motivation to create animated cartoons. Rather, Terry‘s lack of risk taking, external locus of control, tight studio production schedule, desire to compete with neighbour studio Fleischer, difficulty in separating financial rewards from creative processes in animation, and practice of undertaking surveillance measures on staff may have undermined his and his studio‘s creativity. Archival research found Terry to possess strong passions for and to have made significant creative contributions to the field of animation.
Biographical research found that Terry retained a stable nucleus of highly talented artists who dedicated a significant portion of their working careers to the studio. An analysis of the cel aesthetics of a random sample of animated cartoons produced during the years 1930-1955 found that Terry created animated cartoons with above average cel aesthetics when compared to the other studios thereby supporting an inference that Terry was motivated to producing quality crafted animation. Further research is suggested into the role psychodynamic factors and economic decision-making play in the film production process and a clarification of Terry‘s legacy to the field of animated cartoons
Differential involvement of NMDA, AMPA/kainate, and dopamine receptors in the nucleus accumbens core in the acquisition and performance of pavlovian approach behavior
No full textStimuli paired with primary rewards can acquire emotional valence and the ability to elicit automatic, Pavlovian approach responses that have been shown to be mediated by the nucleus accumbens. The present experiment investigated the effects of infusions of glutamatergic or dopaminergic receptor antagonists into the core of the nucleus accumbens on the acquisition and performance of Pavlovian discriminated approach to an appetitive conditioned stimulus. Rats were trained on an autoshaping task in which a conditioned stimulus (CS; a lever) was inserted into the operant chamber for 10 sec, after which a food pellet was delivered. Presentation of another lever (CS) was never followed by food. Subjects developed a conditioned response of approaching and contacting the CS selectively, although food delivery was not in any way contingent on the animals response. A triple dissociation in the effects of AP-5, LY293558 [(3SR, 4aRS, 6RS, 8aRS)-6-[2-(iH-tetrazol-5- yl)ethyl]-1,2,3,4,4a,5,6,7,8,8a-decahydroiso-quinoline-3- carboxylic acid], and -flupenthixol infused into the nucleus accumbens core on the acquisition and performance of this conditioned response was observed. The AMPA/kainate receptor antagonist LY293558 disrupted discriminated approach performance but not acquisition, as evidenced by increased approaches to the CS. In contrast, the NMDA receptor antagonist AP-5 impaired only the acquisition, but not performance, of autoshaping whereas the dopamine D1/D2 receptor antagonist -flupenthixol decreased approaches to the CS during both acquisition and performance. The data are discussed with reference to dissociable interactions of these receptor types with limbic cortical and dopaminergic afferents to the nucleus accumbens core during the acquisition and expression of Pavlovian conditioned approach
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