1,142 research outputs found
Memoires de monsieur du Guay-Trouin, lieutenant general des armeés navales ..
No full textAntepSign. : a-b, A-NA f. de grav. calc. retrato do autorAs f. de grav. preg., planos e escenas navale
Somerset County sheriff\u27s deputy Rene Guay of Jackman, who was involved in the f
No full textSomerset County sheriff\u27s deputy Rene Guay of Jackman, who was involved in the fatal shooting of Katherine Hegarty during a confrontation at her cabin in Dennistown Plantation cabin in May 1992, on Thursday said a barricaded-persons policy approved in February has not been circulated to officers. A member of the Remember Kathy Committee said she was told the policy was in place long ago. Details
Somerset County sheriff\u27s deputy Rene Guay of Jackman, who was involved in the f
No full textSomerset County sheriff\u27s deputy Rene Guay of Jackman, who was involved in the fatal shooting of Katherine Hegarty during a confrontation at her cabin in Dennistown Plantation cabin in May 1992, on Thursday said a barricaded-persons policy approved in February has not been circulated to officers. A member of the Remember Kathy Committee said she was told the policy was in place long ago. Details
Dimensional comparison theory: New models, new methods, new insights
No full textMöller J, Wolff F, Helm F. Dimensional comparison theory: New models, new methods, new insights. In: Dicke T, Guay F, Marsh HW, Craven RG, McInerney DM, eds. Self: A multidisciplinary concept. Charlotte, NC: Information Age Publishing; 2021: 31-57
Comments on “A proportional-integral extremum-seeking controller design technique” [Automatica 77 (2017) 61–67]
No full textIn the proof of [Guay and Dochain (2017), Th.1], Equation 6 is incorrect.Green Open Access added to TU Delft Institutional Repository 'You share, we take care!' - Taverne project https://www.openaccess.nl/en/you-share-we-take-care Otherwise as indicated in the copyright section: the publisher is the copyright holder of this work and the author uses the Dutch legislation to make this work public.Team Sergio GrammaticoTeam Bart De Schutte
Spatial Analysis of Rural Homelessness Support Services in the West Kootenay Region
No full textNursing & Human Service
X-Ray Photoelectron Spectroscopy and X-Ray Diffraction Characterization of Rhodium Oxides in Reductive Conditions
No full textAthabasca School District No. 839 (1958-1959)
No full textPhotograph - Teacher Alice B. Donahue and her grade two class at Athabasca Public School, Athabasca, Alberta. Front row: Daryl Goodwin, Howard McLeod, Rick Zelman, ....Budney, unknown, unknown, Brenda Guay, Pat Mackie, Tim King, Alice Kobzey. Middle row: ....Todd, Lyle ..., Frank McCullough, Janice Locker, Gordon Lines, unknown, Linda Harper, unknown, Paul Gustafson, Vernon ...Back row: unknown, Lorna Jewell, Leon Guay, John McLevin, Carol McKelvey, Gordon Loiselle, Kathy Kaplun, unknown, unknow
Transfer RNA fragments induced during obesity hold regulatory functions in islet macrophage activation and beta cell homeostasis
No full textRole of tRNA fragments in islet macrophage activation and in the crosstalk with β-cells during obesity
No full textIslet-resident macrophages (Mφs) play a key role in pancreatic islet homeostasis but their activation in obesity results in β-cell dysfunction. This activation is likely to be elicited by modulatory molecules highly sensitive to environmental changes. The pool of transfer RNAs (tRNAs) is strictly regulated by nutrient availability and under stress conditions tRNAs can be cleaved, generating fragments (tRFs) with regulatory functions. Moreover, tRFs play a crucial role in extracellular vesicles (EVs)-mediated cell-to-cell crosstalk. The aim of the present work was to determine the impact of obesity on the tRF profile of islet Mφs and to investigate the role of these RNAs in Mφ activation and in the crosstalk with β-cells.
Islet Mφs and β-cells were isolated from obese db/db and lean wild type mice. Small RNA sequencing identified 15 modulated tRFs (≥1.5-fold change, p≤0.05, n=4) in db/db islet Mφs. To assess their role in Mφ activation, we compared the tRF profile of db/db islet Mφs to that of bone marrow derived Mφs (BMDMs), polarized into M1 pro- and M2 anti-inflammatory Mφs. Interestingly, 7 of the tRFs upregulated in db/db islet Mφs were enriched in M2 BMDMs (≥1.5-fold change, p≤0.05, n=3). Inhibition of one of these fragments, 5’tRFGlu(CTC), led to profound transcriptomic changes in both M1 and M2 BMDMs (n=3), with a preferential impact on genes involved in T-cell stimulation and in acute immune responses. Among the tRFs upregulated in obese islet Mφs, 5’tRFGlu(CTC), 5’tRFGly(GCC) and 5’tRFAsp(GTC) were also increased in β-cells of db/db mice and were abundant in EVs released by M2 BMDMs, suggesting a possible role in the crosstalk between islet cells.
Our data suggest that tRFs may act as key modulators of Mφs activation and that obesity induces an upregulation of anti-inflammatory tRFs in islet Mφs. RNA labelling and EVs transfer techniques are currently being used to investigate the contribution of tRFs in Mφ-β-cell crosstalk
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