3,122 research outputs found

    Visualizing and characterizing tissue abnormalities in multiple sclerosis: A translational approach

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    Geurts, J.J.G. [Promotor]Barkhof, F. [Promotor]Inglese, M. [Copromotor

    A Dynamic Subfilter-scale Stress Model for Large Eddy Simulations Based on Physical Flow Scales

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    We propose a new definition of the length scale in an eddy-viscosity model for large-eddy simulations (LES). This formulation extends and generalizes a previous proposal [Piomelli, Rouhi and Geurts, Proc. ETMM10, 2014], in which the LES length scale was expressed in terms of the integral length-scale of turbulence determined by the flow characteristics and explicitly decoupled from the simulation grid; this approach was named Integral Length-Scale Approximation (ILSA). As in the original ILSA, the model coefficient was determined by the user, and required to maintain a desired contribution of the unresolved, subfilter scales (SFS) to the global transport. We propose a local formulation (local ILSA) in which the model coefficient is local in space, allowing a precise control over SFS activity as a function of location. This new formulation preserves the properties of the global model; application to channel flow and backward-facing step verifies its features and accuracy

    The irony of iron: MRI and brain iron in multiple sclerosis

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    Geurts, J.J.G. [Promotor]Barkhof, F. [Promotor]Zivadinov, R. [Copromotor

    Towards endophenotyping multiple sclerosis

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    Polman, C.H. [Promotor]Geurts, J.J.G. [Promotor]Uitdehaag, B.M.J. [Copromotor]Barkhof, F. [Copromotor

    Looking through the macroscope: 7 Tesla MRI in multiple sclerosis

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    Barkhof, F. [Promotor]Geurts, J.J.G. [Promotor]Pouwels, P.J.W. [Copromotor]Wattjes, M.P. [Copromotor

    Are you connected?: A network perspective on cognitive dysfunction in early multiple sclerosis

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    Barkhof, F. [Promotor]Geurts, J.J.G. [Promotor]Polman, C.H. [Copromotor]Vrenken, H. [Copromotor

    Understanding the shrinking brain in multiple sclerosis: multimodal MRI studies

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    Barkhof, F. [Promotor]Geurts, J.J.G. [Promotor]Vrenken, H. [Copromotor]Pouwels, P.J.W. [Copromotor

    3D and Subtraction MR imaging in Multiple Sclerosis : Improved detection of spatiotemporal disease activity

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    Barkhof, F. [Promotor]Polman, C.H. [Promotor]Geurts, J.J.G. [Copromotor]Vrenken, H. [Copromotor

    Imaging patterns of inflammation in multiple sclerosis: a multifocal approach

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    Polman, C.H. [Promotor]Barkhof, F. [Promotor]Geurts, J.J.G. [Copromotor]Vrenken, H. [Copromotor
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