20 research outputs found
Aspergillus fumigatus toxins cause cytotoxic and apoptotic effects on human T lymphocytes (Jurkat cells)
No full text
Fast Field Echo Imaging and Dynamic Gadolinium-DTPA-Enhanced Magnetic Resonance Imaging in Vascular Malformations
No full text
Different types of cultured human adult cardiac progenitor cells have a high degree of transcriptome similarity
No full textTaken together, our data suggest that human CPCs can be iso-
lated from patient heart biopsies using different markers, such as
c-kit or Sca-1- like, and alternative methodologies,
via
direct cell iso-
lation or
via
explant culture, such as CSps and CDCs. For the first
time, however, we showed that upon culture expansion, these cell
populations have a very similar gene expression profile, even more
pronounced when cultured in comparable culture conditions and even
transcended by donor differences. Our findings are of fundamental importance to create a con-
sensus among different scientists in the field of myocardial regenera-
tion, which should help align future clinical approaches to improve
the reported beneficial effects of cell therapy for heart disease by
using cardiac derived progenitor cell populations
Research update for articles published in EJCI in 2014
No full textOur findings showed that p53 mRNA expression levels are upregulated in epicardial adipose tissue (EAT) from patients with heart failure (HF). This upregulation was also found in myocardium [2]. Our group have described its upregulation in EAT by sympathetic system. This article is protected by copyright. All rights reserved
The International Journal of Cardiovascular Imaging / Effects of levosimendan on cardiac function, size and strain in heart failure patients
No full textLevosimendan improves cardiac function in heart failure populations; however, its exact mechanism is not well defined. We analysed the short-term impact of levosimendan in heart failure patients with ischemic and non-ischemic cardiomyopathy (CMP) using multiparametric cardiac magnetic resonance (CMR). We identified 33 patients with ischemic or non-ischemic CMP who received two consecutive CMR scans prior to and within one week after levosimendan administration. Changes in LV ejection fraction (LVEF) and LV volumes, as well as changes in strain rates, were measured prior to and within one week after levosimendan infusion. LV scarring, based on late gadolinium enhancement (LGE), was correlated to changes in LV size and strain rates. Both LV endiastolic (EDV) and endsystolic volumes (ESV) significantly decreased (EDV: p=0,001; ESV: p=0,002) after levosimendan administration, with no significant impact on LVEF (p=0.41), cardiac output (p=0.61), and strain rates. Subgroup analyses of ischemic or non-ischemic CMP showed no significant differences between the groups in terms of short-term LV reverse remodeling. The presence and extent of scarring in LGE did not correlate with changes in LV size and strain rates. CMR is able to monitor cardiac effects of levosimendan infusion. Short-term follow-up of a single levosimendan infusion using CMR shows a significant decrease in LV size, but no impact on LVEF or strain measurements. There was no difference between patients with ischemic or non-ischemic CMP. Quantification of LV scarring in CMR is not able to predict changes in LV size and strain rates in response to levosimendan
