3,641 research outputs found
Amélie Gex (1835-1883) : un poète savoyard : notes biographiques et correspondance / F. Vermale ; préface de F. Grange
No full textComprend : CorrespondanceAppartient à l’ensemble documentaire : RhoneAlp1Contient une table des matièresAvec mode text
Elm Grange
No full textElm Grange is located on the east side of route 13 approximately one mile north of McDonough. The nomination contains one acre including the house and none of the extant agricultural buildings
Reproductive success in Antarctic marine invertebrates
No full textThe nearshore Antarctic marine environment is unique, characterised by low but constant temperatures that contrast with an intense peak in productivity. As a result of this stenothermal environment, energy input has a profound ecological effect. These conditions have developed over several millions of years and have resulted in an animal physiology that is highly stenothermal and sometimes closely coupled with the seasonal food supply, e.g. reproductive periodicity and food storage. Therefore, Antarctic marine animals are likely to be amongst the most vulnerable species worldwide to environmental modifications and can be regarded as highly sensitive barometers for change. Reproductive success is a vital characteristic in species survival and evaluation of change in reproductive condition with time key to identifying vulnerable taxa. Characterising reproductive success with time is a major requirement in predicting species response to change and the early stages of species loss.Some invertebrates are highly abundant in shallow water sites around the Antarctic and form conspicuous members of the Antarctic benthos. Three common echinoderms and one nemertean were sampled from sites adjacent to the British Antarctic Survey’s Rothera Research Station, Adelaide Island, on the West Antarctic Peninsula between 1997-2001. Reproductive patterns were determined by histological analyses of gonad tissue.This study provided further evidence for inter-annual variation in Antarctic gametogenic development, which appeared to be driven to some extent by trophic position and reliance on the seasonal phytoplankton bloom. The largest variation in reproductive condition was demonstrated for the detritivorous brittle star, Ophionotus victoriae. The seasonal tempos of this echinoderm have been attributed in part, to the seasonal sedimentation events common in the high Antarctic. The reproductive patterns in the scavenging starfish, Odontaster validus and the predatory nemertean, Parborlasia corrugatus showed less inter-annual variation. The de-coupling of these invertebrates from the intensely seasonal phytoplankton bloom appeared to partially account for the reproductive trends observed. The lack of inter-annual variation in the reproduction of the filter-feeding sea-cucumber, Heterocucumis steineni, was somewhat counterintuitive, although problems with sample processing probably accounted for the majority of this anomaly.Echinoderms were also collected during the Antarctic summer field seasons in 2003 and 2004. A series of fertilisation success studies were undertaken comparing the adaptations in an Antarctic and an equivalent temperate starfish to achieve optimal numbers of fertilised eggs, and elemental analyses were used to estimate the nutritional and energetic condition of the bodily and reproductive tissues in two Antarctic echinoderms.Fertilisation studies indicated that Antarctic invertebrates require 1-2 orders of magnitude more sperm to ensure optimal fertilisation success. These sperm tended to be long-lived and capable of fertilising eggs 24+ hours after release. The study suggested that synchronous spawning, aggregations and specific pre-spawning behaviour are employed to help counter the deleterious effects of sperm limitation. The Antarctic eggs and sperm were also highly sensitive to even small modifications in temperature and salinity, affecting the number of eggs fertilised. Such stenothermy is of particular relevance if the 1-2ºC rise in global temperature, predicted over the next century, is realised.Biochemical composition of body components of two species of Antarctic echinoderm indicated a significant difference in the composition between the male and female gonad, particularly in the Antarctic brittle star Ophionotus victoriae. The ovaries contained a much larger proportion of lipid compared to the testes, and demonstrated a distinct seasonality in composition. Higher levels of lipid were observed in the ovary during the austral winter coincident with a period of reproductive investment and maturing oocytes in the gonad. O. victoriae exhibited lower amounts of lipid in the late austral spring suggesting the removal of mature oocytes from the ovary through spawning. The seasonality in composition and the high levels of lipid and protein measured in the ophiuroid gut tissue, suggested the gut might play a role in providing material and energy for metabolic function and possibly gametogenesis; higher lipid levels were apparent during the period of seasonal phytodetrital flux. The role of the pyloric ceaca in asteroids as a nutrient storage organ was also evident in the high levels of both protein and lipid observed in this bodily component in the star fish, Odontaster validus
Current Issues and Regulations in Tendon Regeneration and Musculoskeletal Repair with Mesenchymal Stem Cells
No full textMesenchymal stem cells are multipotent stromal cells residing within the connective tissue of most organs. Their surface phenotype has been well described. Most commonly, mesenchymal stem cells demonstrate the ability to differentiate into mesenchymal tissues (bone, catailge, fat, etc...), however, under the proper conditions these cells can differentiate into epithelial cells and neuroectoderm derived lineages. Their developmental plasticity also depends on the ability of mesenchymal stem cells to alter the tissue microenvironment by secreting soluble factors, as well as their capacity for differentiation in tissue repair. It is the cell-matrix interaction which defines the tissue characteristics. The molecular and functional heterogeneity of this cell population may confound interpretation of their differentiation potential, but it is this heterogeneity that is believed to provide for their therapeutic efficacy. Stem cell therapies are an attractive therapeutic approach for soft tissues as they offer a vehicle for repair and regeneration at the end of a needle. The early introduction of stem cell treatments into the therapeutic armamentarium involves both commercial and non-commercial multidisciplinary partnerships and has occurred in a climate of regulatory reform, so not all the relevant information resides in the public domain, but early clinical studies have shown promising results. Against this backdrop, novel techniques and early results of a small series of tendon and musculotendinous junction interventions are being published and other ongoing studies are yet to report their results. The issue of ensuring governance of these novel technologies falls upon both the scientific community and the established licensing authorities
House Guests : The Grange 1817 to Today
No full text"Built by the Boulton family between 1817 and 1820, The Grange is Toronto's oldest remaining brick house and a national historic site. The Grange was bequeathed at the beginning of the twentieth century to become the home of Toronto''s first art museum. During the nineteenth century, The Grange was at the centre of this city's social and political activity. Today, with its collection of furniture, artifacts and art, it is an historic house museum and a unique part of the Art Gallery of Ontario. The house embodies the AGO''s development over the past century, when it grew to become the eighth largest art museum in North America.
The works of several contemporary artists will be special 'guests' in The Grange, the Gallery's first home, in celebration of the Art Gallery of Ontario's first century and the fact that the Gallery was founded with the work of then living artists. The exhibition, which is entitled House Guests: Contemporary Artists in The Grange, provides the opportunity to interweave our past and our future. Drawing upon the continuous transformations that have characterized The Grange, its holdings and its social and cultural role, these artists have been invited to respond to this rich site with works that will be installed throughout the house. This co-mingling of historical and contemporary forces will reveal our artistic heritage as the living legacy from which many current artistic practices are fashioned.
The exhibition will be accompanied by the publication of a book, featuring an essay about The Grange by Charlotte Gray, author of Sisters in the Wilderness. The artists participating in House Guests will provide commentary on their installations and the impact that the house and its place in Toronto's history and culture had on their creative process. " -- Publisher's website
Release of MicroRNA-Containing Vesicles Can Stimulate Angiogenesis and Metastasis in Renal Carcinoma
No full textRenal cell carcinoma is a common form of urologic tumor, with low incidence but a high metastatic rate at diagnosis and high frequency of relapse. Renal cell carcinoma comprises a heterogeneous group of subtypes, classified according to their histopathological features and clinical behavior. Diagnostic approaches used to identify malignant tissue are based on immunohistochemical techniques. However, new molecular methods have been recently proposed for profiling and staging renal tumors based on their microRNA (miRNAs) expression. In fact, miRNAs have been shown to have abnormal levels in many cancers compared with their normal tissue counterparts. For this reason, along with the fact that they are present in biological fluids, miRNAs could serve as a useful diagnostic tool. Moreover, miRNAs may modify the translational profile of cells through direct degradation of their target mRNAs or by blocking their translation into functional proteins. The biological function of secretory miRNAs requires protection from extracellular degrading enzymes, which is achieved by envelopment of miRNAs within extracellular vesicles (EVs), which are subsequently secreted. EVs are a heterogeneous population of vesicles that includes shedding vesicles and exosomes, and are variable in size, composition, and releasing mechanisms. Following uptake, EVs are able to induce epigenetic modifications in target cells by the transfer of active proteins, lipids, RNA, and miRNAs. Therefore, through the transfer of selected miRNAs, tumor-released EVs may provide oncogenic signals to stromal cells. In particular, EVs released from renal carcinoma stem cells contain miRNAs that are potentially involved in triggering angiogenesis and metastasis
Médus // roy des Mèdes // tragédie // mise en musique // par Monsieur Bouvard // et // Représentée pour la premiere fois // Par L'academie Royale de Musique // Le Vingt troisiême jour du mois de Juillet 1702. // Les paroles sont de Mr de la Grange
No full textAncien possesseur : France. Intendance des Menus Plaisirs et affaires de la Chambre du roi. Ancien possesseurTitre uniforme : Bouvard, François (1683?-1760). Compositeur. [Médus, roi des Mèdes]Tragédie lyrique en 5 actes. - Livret de François-Joseph de La Grange-Chancel. - 1re représentation : Paris, Académie royale de musique, juillet 1702. - Rôles : un matelot (Ut 3), un berger (Ut 3), un guerrier (Ut 3), la Fortune (Ut 1), un François (Ut 3), Médée (Ut 1), Ciane (Ut 1), Thomiris (Ut 1), Thoas (Fa 4), Persès (Fa 4), un habitant d'Anticire (Sol 2), Médus (Fa 4), Minerve (Ut 1), une Européenne (Sol 2), le Soleil (Ut 3). - Choeur : Sol 2 (2), Ut 1, Ut 3, Fa 4. - Instruments : Sol 1 (2), Fa 4. - Mentions d'instrumentation sous la musique : violons (2), trompettes (2), flutes alemandes (2). - Même copiste que F-Pn Rés. Vm2. 71. - F. 2r° : table des décorations avec gravure, f. 2v° : table des personnages du prologue avec gravure et noms des interprètes. - Entre le prologue et le 1er acte : table des acteurs de la tragédie avec gravure et noms des interprètes. - Entre les actes 2 et 3, p. gr. - À la fin, tables des airs de violons et des airs à chanter avec gravures. - Éd. : Paris : C. Ballard, 1702. - Même copiste que Rés. Vm22. 71Présentation musicale : [Partition]Incipit : Ô puissante divinitéAppartient à l’ensemble documentaire : RISM1Appartient à l’ensemble documentaire : RISMMssOpéras -- +* 1700......- 1799......+:18e siècle
M/V Lynton Grange for Fowler and White, F
No full textM/V Lynton Grange deck. View from the top of the mast looking down at the deck and nearby shore. Photo taken for Fowler and White.https://digitalcommons.usf.edu/gandy/6394/thumbnail.jp
The biography of the immune system and the control of cancer: from St Peregrine to contemporary vaccination strategies
No full textBackground: The historical basis and contemporary evidence for the use of immune strategies for prevention of malignancies are reviewed. Emphasis is focussed on the Febrile Infections and Melanoma (FEBIM) study on melanoma and on malignancies that seem to be related to an overexpression of human endogenous retrovirus K (HERV-K). Discussion: It is claimed that, as a result of recent observational studies, measures for prevention of some malignancies such as melanoma and certain forms of leukaemia are already at hand: vaccination with Bacille Calmette-Guerin (BCG) of new-borns and vaccination with the yellow fever 17D (YFV) vaccine of adults. While the evidence of their benefit for prevention of malignancies requires substantiation, the observations that vaccinations with BCG and/or vaccinia early in life improved the outcome of patients after surgical therapy of melanoma are of practical relevance as the survival advantage conferred by prior vaccination is greater than any contemporary adjuvant therapy. Summary: The reviewed findings open a debate as to whether controlled vaccination studies should be conducted in patients and/or regions for whom/where they are needed most urgently. A study proposal is made and discussed. If protection is confirmed, the development of novel recombinant vaccines with wider ranges of protection based, most likely, on BCG, YFV or vaccinia, could be attempted
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