4 research outputs found

    Interaction studies of a β-cysteine functionalized polythiophene with biomolecules

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    Polythiophenes are an important representative class of conjugated and thermally stable polymers that can be used in alternative to inorganic semiconductors in optical and electronic devices [1]. Recently, they have been studied as biological sensors [2], thanks to the presence of the electroconducting backbone together with β-substituents able to interact with biological species. The interaction between the polymer side chain functionalities and the analyte can be of different type (hydrogen bonds, ionic interactions ...) depending on the analyte, or the backbone itself can directly interact with the biomolecule through π-π stacking.In this study, a previously synthesized β-cysteine functionalized polythiophene (PTCys, Fig 1) [3] was investigated as folic acid [4] and cytochrome C (horse heart) biosensor.[1] Skotheim Ed. T., Reynolds J., Elsenbamer R., Dekker Marcel, Inc., New York, NY, USA, Handbook of conducting polymers 2nd Edition, 1998; Skotheim Ed. T., Dekker Marcel, Inc., New York, NY, USA, Handbook of conducting polymers 1986[2] Berggren, M.; Inganas, O.; Gustafsson, G.; Nature,1994, 372, 444-446[3] Cagnoli R., Lanzi M., Mucci A., Parenti F., Schenetti L., Polymer, 2005, 46(11), 3588-3596[4] Zhiyi Yao, Chun Li and Gaoquan Shi, Langmuir,2008, 24, 12829-1283

    Non-alcoholic Fatty Liver Disease: a HR-MAS analysis

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    Non-alcoholic fatty liver disease (NAFLD) is a common cause of chronicliver disease. The NAFLD includes non-alcoholic fatty liver (NAFL) andnon-alcoholic steatohepatitis (NASH). The mechanisms of NAFLD to NASH transition remain to be clarified. NAFLD appears to originate from the dysregulation of hepatic lipid metabolism as a part of the metabolicsyndrome accompanied by visceral obesity dyslipidemia, atherosclerosis, and insulin resistance. High Resolution Magic Angle Spinning (HR-MAS) NMR is a useful tool for the metabolic characterization of intact tissues and can be used to support the clinical diagnosis. The aim of this study is to characterized the NAFLD and NASH metabolism using HR-MAS NMR Spectroscopy, and to evaluate the possible transition from NAFLD to NASH. Liver needle biopsies were collected for the HR-MAS and histological analyses. Preliminary HR-MAS NMR results show a higher amount of lipids in the biopsies from patients with 30-50% of steatosis, whereas lipids and of small metabolites are present when the liver is affected from a market fibrosis

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    THK AITO OONTEUT rlo-sca thl* rsi-alag at 0 o'clock, sad ao rote* will br mwmed ar- ter thai tlmr. VtHos ramj he trapmUred at th* Fbst N allow- al Ileal, till S i .'chick inummis iatttj falxi Alta ®utu>j3 Ten .-.. ,..! tbl. Uooa lor 10 1 N.1T OOOI. AITE-n FKB. 1 VOLUME 39 EIGHT PAGES PALO ALTO. CAL, THURSDAY. I-'KII jo- 191a EIGHT PAGES NO 19 GARDEN HOSE - WE HAVE Jl'ST in ' l IV! l» IllltECT FROM THE FACTORY Ot ibe M*J York Betting t Packing Co. 0.730 FEET Of OAK- DEN HOME, It l-rlcg a part of oar annual ahtpmanl. It la made expressly for ttt* PALO ALTO HARDWARE COMPANY. Erary foot la guaranteed for on* y*ar from tli* data ot purcbas*. Yon cannot bar any baltar at aay price, aad rou wilt find oar prices most r*a*ooBbl« at the lllgtit In Ihr (Vnii-r of thr City. Auto Delivery DUDFIELD LUMBER CO. • Specialists ia MUlworK Foreft Ave. and 4lma Street in,... in yard aii him. ana. CANDV CIVIC WORKERS MANY PRESENT KNIGHT OF JIMMY HEAR MRS COOLIDGE ' AT OPENING! LIVES IN STATE SALE Saturday March 2 L. Peanut Taffy Two Pounds FttOHINKNT I1KKKEI.KV W(IHAN| AHT RXH1BIT AT HIGH M'lHKtL HEI.IYEItsi INSTItl 'CTIVE HTllHl' ATTttAOXB Mt.VY AlHlKKS**. Tli.-lt. Explain* Illy llond 1- i,. In I .mid Manm-r llcl<irr lliitlir*, 35c ll_» 2 I-..U-M1. at 1,-ifnlai |irlrr. Th* program of thr meeting of tin- rlvlr center held y--*trrdav af- ' icrauon aa* of itarllralar Interest ■ 'I'll, speaker of th* day was Mr* Mary Roberts Coolldge or llcrketer. i talks alto bsrlng given by Mrs. Kait (1 Itradiorff and K C. Tboli*. member ut the city coudcII. | , Mr* Itriidforff. wbo was (he first | sprakrr. gave the lesson on regls- t tralltia. saying thai th* vote 1* aot a test or i Mi*..ii*.iit|i and I* under State, not federal, roatrol. la a , few of th* southern stale* reglstra- _ Una Is not -'-..-ulrrd of. voters, gad , all of ,tli* state* 'but i_M Jiav*';, ao' educations'! i|*iaII1tra'Uo*js i Mr*. HKNIOEVTH. ■rm. ni Hrho.il PwptU AM In Pre. -. i.'u't Aflrrnnua's VartrsJ I'rotrrani. Tbts afternoon ihe high school an -iuilln I* alive with people taking the flrst opportunity of studying repnuis of portrait, animal, edlflc* and landscape painting* by (he renowned artist* of history, which adorn (ho wall* of (he building In the Elton art exhlbli. A pleaalag lltiK- program constating nr songs by tbe third and loarth grade* of tbr Homer-avenue school and lh* H fifth -trade of .,yiton aveaui color lo the entertainment. Hi,tin- continuation or the i-xhiblt from 710 in .•** In toalght a varied fiXncjsni »1H; lM*trendered. Hxplaa- SU*r> -frma»k»!'tf*l J. f Templeton. lUlialrai . tituiitu■>• by '-the A fifth LAST DAY .Win 1 TIME IN* WHICH TO LOSE A GREAT OPPORTVNITY. gln.rt tin* la whkh to w..rk for oae of the fliw fl.fBOO tallj- r-julpp d flvivp-M* eager Al'TOS thai are ln-in* gtxeo awaj. IT llfc- flOOVKH YOC TO lit'ATI JS. FROM NOW I NTH, FKBRt'Attl WW THE IlO.N'ta OP VoiKs WILL I1E AA FOLLOWS: wash iiow .bo 1.000 1.0.- S.000 1.00 Trade Book l.OOO R.OO Tradr Book B.OOO Weingartner & Co. Rexall Store MaKe your selection now for a spring; suit Fabrics to suit every taste 3030—35 B. P. Laosten The Tailor OX THK CIRCLE Moved to 273 University Avenne Pioneer Furniture Man W.F.PENNEBAKER A rordlal Invitation 1* extended to old friend* and new to vUlt this furnltur* store PHONE «67.T Palo Alto Lumber Co. Lumber. Millwork Baildlne Materials, Lime J. O. ROI1IN J- 'N. Manager. tioraUoa *->*i_ ef Aoartbrra PaetAc Frrlgfat I>ef*ot. FAIR u\K** MM Toil in iiiiw:i> ll\ l\k sll IT OM Cx**T*or*K TIUtfAKRH. iniii.il I* KHi'-ii.l In llu- Man "t (.■ ..ii. Worth aad E*c*-|-rnt Brer-Wng. Me-re-j* u-, Tnls*. ! Kendloi-Jf alto'referred to ih* early • _***-adc- daoble/ovWrttls^tHr gtstumar The** highway*,.,(U*it)*fttt-*^ of (he.-"-i»-o,"*:'-w •'•"Ing safffcagt?.* ■Pol»o*r-[ trrhObl'; "felrls* *Sh\* club, (he hlgb Nalloaal Federallon of ■ Woman', '-'v Wr*. Hendtortfs talk ther* wa*i»rjlrjo| o'n*_hestra. ' the litgli jjsrhoel ('lull* have seat a Imshel or two or an Inli-risstlns dlsrusslon by Mrs | boy*' gits* club, and by Mils**/•*».tr sweet pern* tor fro* dtatriballoB to CoAlldge. Mr*. Alk* I, Park and ,8trien*. hi«b school ptanVT and ^J~_~2IJ^1| any wbo will plant (hem. Alt Ibat SI*-* J,,"a R Ollberl. jphrslcal <■*..**. i**-* by lb* Homer ' " I* asked Is lhat the seeds he *-.lBBt-_ r' «" Thalia explained clly - bond avenue fourth grade, alou,. have nl and cased for and a few bouquets I**"1"' ''- xentral wllh special' ret-' ,)_.___,»!; , poaer elkDagr. to mor*; of bloo-iti, t*e conirlbaied for " th* "-rrni-r to the |iro|sr**i>d bond Issue ,___,,„ W|Ual* Ikg It ntfl 10 -rents ad. wtitaen who visit Palo 'Alio at tha '■> Polo Alto, which roqalra* a <***<»-L tiii*-!nt- rharge*. Um* of th* biennial convention n*xl thlMts fnsjorlty vnt* to carry. He. Today Uhj randy Ml-*; and te» ret June of the bb recelvV a handful »h»*-il thai *fl*r bonda are Ifurd.],, tn procure pilsr* fn seeds b> j-aillng w|Min Mrs. "-a*t'> ptfrfr Ik- Wlfd aiifllclent for, den coale»l sre, belag ' Som? Very Choice Bargains ih* Anihony at her filace' of b"a*l* ■■>■' ln(ers-*( «n and redemption of th*. w. »hc I'alo Alto El*t-trlealt-'<*n,l 1**U"W There are two kind* (. ,t«5 fri.lrerslty avrau*. far! Imndt. miniirotlurlng and In* ... runic iiriHturlna. In ihij 8r*t class |ar* public buildings,-' sewer*. Are i.l health prutrctloa and library i|.r'ivt-tiii-nts tn the *eeond ar« |.uMlr ntilltls-*. suth a* Ihe light anil waier plants,' ahlrh are Invsat- meal* paying a surplu* Into the gen- gN.OOti—One of the pifntlest liomr* era) fund and dlmlnUhlng taxation. In Palo Alto for sal* al A The pnn-fMted library Iwind will ■*> bargain: t.-en rnoens, sleep- nulre slxiut 2 r*ntr on every ||00 ing porch, large villa lot,'from tin- taxpasa-rs'lhe fir*! T**r on sunny corner. Must be seen a forij-var boad. thr amounl lie- . to be A|>|ir<-i-lati'd specially lac rrdtm-.l yearh tcood Mr* Coolldge I sase a report of f-V.TOO—lO-room modi-rn liou**-. ibe work nf the l"aan.<- and II* mm- wlthtB flfieen ir.lnutn' walk tn. "Rludy and service" Sin gave or Hianford'. Cniverslty; -ao the MataaMAt or a WtotOSOOt In th.- acre of ground highly Im-. l'nU-r*l'* «f I'atlfnml* thai thr ■■roved; fruit trees and franchise aa* of ln**tlni*bl* value shrubbery. .**'a(cr plant and tai vnim-n, more lor tin- study «f exrs-llrn.t aril, aiodera barti; lfni*urtant i,u--Bflon» tbsn for the „__, all! exrbang* for utilm- voir, wivlna that ixilltlrlati* innnni Artiind alih an rxiellrnt desertp- llon of th* ecs-entrlc barglsr who* slept In fealher bed*, left -ailing card*, and clothed bimaelf In fln*> raiment, at Fair Oak* on Snnday nlghl lh* pollr* r\--.,i to land tho knight of the Jimmy by tomorrow. The doarrlt'llon wa* -furnished by an Ink *pol on Ibe clothing be left In lieu of Ihe finer dud* taken from the ii»1*ii*I wardrobe of l-onl* 8t«rn. Charles tlregory ot Ited wood city, oa seelBg lb* clotbv* left by the Imralsf recognised them aa worn by a nt*n who bad played pool at his jilan- of bualneaa on **v*ral mission* One nlgbl (br man asked If he could writ* a letter.. Wbllw a riling hr dropped some Ink on lb* left trouser leg of his trousers. Af- ti* sheriff, tlregory de*rribed the *)■>( aad It* I location. It was there. " The man wa* cheaptt drr*s*>d. i but of i-iilMii-il manner and rxesd- ' teat breeding.- Thr sheriff's offlr** lirlli-iis hi* natural aversion to the poor sr*ilr or rlolbe* he was wear- Ilng Lii him lo take the Atera Ullor- . .. a_Tal^^|siw.|J?^ ***'*** *»***»»******* »»* exhibit wll, be under'tb4,h0W' Mm th** hU k,B«,« **\ ot the v..mi in nl ilii- horn**'"*■*'" *l"*l> lD '■,"' ,"**hrr% Inateadl > inrn »mc hi* te-iise of hen Ihe fluff-, bill'at tin- if Mrs Wlncbr*irr wooodl irted t.yl.1 aus|i|--e* and t-ehool rluh. ToiiiorroN sll. ruiM-ii thr program tendered will be by ihr |.>|tfm-i asi-iim- scti.Kil rhlldreti a*'follow*: j t Cimnrt rerllatlon by .l..imn-_ .ivs-tiiie third arnde. 'The Elephant** Child." » .' Snnas bv t'.vttnn-avi-nu-' third ami fourth grade* -" •-»*-"' a Thr Violet.'; Ihtrd. r.raitr ■ b Krii-iida." f-iutilv grade. • e. "Old Otnry." fottrib gratlr* t -I I !>•• Nobody Man." third and fnnMli (ta,.. lii III tn |M! prove*] or orchard land. J—Z arrea In orchard, a mil* or thr *tallon. elcelrlr and steam lool iH-oiit* •* in know. rltbln* Mrs. Coolldge said "W.. «sn' both io leam. Demoerary waa no( d~ road: m-n-ra.-y io lilt H Is Ilk* lbe Mr*. K 0, llroen- Him rlaliu. vote of thanks be the niienker*. " ' Mr* llradfi.nl gave (he of fir M. A. Ma libra* o led lirTfiT^gtit for I r mayor of lhat elty. d that a ti nder*-.! f Seattle. Doctor Maitfaatva urgrl womon to "tutly. A ih «i i if.tinn ot thr man hay t baaa furnl*b*d every laUlllaaiaaa*' •iffii,. nn >he I'--ii/lctiiu and a shsrsV IbokotH Is being 'gialntalned for hi* ■ hereabouts. ■--■ Corner, IDOiSflfr. (hree blocks from Malum, 1-os Altos; oak and fruit ire**. Tea p*r real rash. balance !■-** lll-lli tl'. in.null!. Will enhance greatly- University Realty Co. I' ■! Alio ami Kan Franclsro. ■malt house, barn aad chirk* tiotttrn Utile. It grow* by practlr-e.j en house;' located betweea 11 Is a far-off word- something '" Btaaford I'nlversity and Loff utrlv,. toward, like religion." Alto*. . Mrs 'Conlidge gave an outlln. nf l W* can mak* Iwo loan*, from the work so far as It ha* been pre-* tl.POO (o fi.OOi'. on I'alo Alto t-arrd. Thr. .vllaM alreadv l**ardj proia-rty at t por cent per annum ur* on "Cltlienshlp" and "Itrgl*tra-* For partlc-alara addr-cas tlon." . 1.1-'* -»ub)*-*-*> at ihr-*r- *o* he*J THE J. j" MORltIA RRAI. fWTATE t**u*d are "Thr ,"np,olrci*d Olrl."< COMPANY . "The Tecbnltiur of Voting" andi AOENTM PALO AI.TO -The Social Bvll," Entirenew stock opened March 1st Nobby high grade goods at popular prices OTTO WlDEMAN HABERDASHER With i. D.WIdetnan. Novelty Theater THK'KAMIl.Y 111 .nn i 111 . I nl I ill 1 Ml', I Thursday.jdjfl'Fjida-jf.. ?-***.?» T* PATHE'S WEEKLY •"■■a ill fills i.uinl- r a «Ts-at ■,..... i.,|.i..imk event*. Irs-flt a'l ttmrte of tlir World.. - " " ANN T 111(1,1. <-TIIF.lt in I I.-. Nd 111 VANCE. . • FIRMT SHOW 1:*A P. M. MflMitV MtJHT OM.V—It ft. 1VM. MdKI.KV wtll glvr aa Hlus. Ualed lerture mm "PIUHON ldr*F." IN JOI.IKT PHI.'MlV, ll-L AttsStmmmm IO n-sla. Ursi Mima T P. M. Interested In Children's Shoes? THOSE NEW ONTO WE RAVE lll'EN TALKING ABOL'T AIIF WORTH LOOKINO AT. TIIBV HAVE APPEAIlANtT: ANI» THE -II Ml s ARK OOOD FOR GROWING FEET. TAN ANIl III Ifl. CALF. 3\vsaX5~"^ If You Want What You Want When You Want It ■ i-.i ti a Having* Aceouni. . torn OSmTt 3APU tuoary a* lowg a* H I* In lour pottu*—and It don't draa Intr-rrat'the—*.. "linl*- i|i..j- of walr-r niak<- the ihi--I.ii o-reati"—do pis ralcli afsT The. Firsl National Bank, Palo Alto omoostcui. a.m. .him,. The Santa Fe Lumber Company Located Opposite Mayfield Depot Telephone Vour Want* to Palo Alto 268

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    TilF. DAILY PALO ALTO TIMfc. soathi-rn r*ciltr To San Francisco- to. 31—5:00 a. m. le*. 3S—6:30 a. tn. lo. i.i -ti 17 a. in i.ill}. sally. No. 3»—7 »i a. i No. 41—8 it i*. i 29—fl * I a. i 27 — 11:01 a. No No. No. No.' -ll . 47—2:55 p. to No. 25—4.36 p. ui No. 49—5:05 p. at No. 51—$ 14 p. Dl No. 53**—7.atl p. m To Sao Joaa— No. 23—7 40 a id No. 24—S.ot a. m No. 31—10:25 a i .No. 31—11:45 fc. r No- 38—12.4* p. I No. 40—3 12 p nt No. ti—3 Jt; p ni N'o. 30—-I -44 p n> No. 42—5 25 p. m No u -t Oi, p. m No to—( i5 p 0. No it—7.07 p, m No Mi 45 p. it 30 p m dhll) eir*»pt P dally dally. daily, datlj. dally. i. dally, daily. dally. datJy. dally. dally. . J dally. daily. dally. daily. i dally, dall). daily, tlsily. dally- dally except S. dally. dally daily. dall* Or. J W. Coolidge baA returned from an extended «i»tcrn trip. MUe Jetutlo Bait, of Benkla. Is : 'pending her vacation with her pttr- >*nl9. Mr tfnd Mis. It. ll. Hell Ho** I» Howard, who has ew- ; pltjt.-d his tuorso at Stanford, left I tins forenoon /or Vttri Collins, Col. ftflai Maty DuIIom* htm resinned ht l poaMoa at the Guild Hoapltal Lu-d -__ sptud tha remainder of the Vtatar at her home In Eletbcli-y 1 Mr. and Mrs Sli.io Uouione ha\ ■ !leaecd tbo voltage at 720 V ..*• j-* r I atrt*et and will m.K.- thi*u li.nn.- CHINAMAN HURT DURING RUNAWAY!; i*\i.o lura miknks 1110* KNOW vl'Ul.l JIM >HiK. I'lii •! Kit It'll OF VKtiK* TABLK ti.UtllKS \T IMMPIXG ST.ITIOX. IS tf-HK VICTIM. Cone I'pen ber rcl-trn Ur and Mrs all) ba ai borne at 53? W.-t. > otitis ladl* thr holiday A hO.lt work local 3ots • Mn Mi: Hairl«ot . 01 Man 9 ittor thi* *M**h. g| th-* home ot Johnson ot Oakland. »i*-»n* -ek* «*nd with Mr* E. 11 Pro i-wiot an.! \l*- M i, l'..it).ind. On Palo Alio. Ml OpMM for Its sa«. tomorrow. Mr. and Mr*. Kotwri i^r'have re- t ni tied from Aberdt-wu, Wash., where pa* bt .*n for the paat two I Mkl their home in Palo -■•fit the guests ot Mr*, t;. -MQson. The engaoeman* has be*i<n an* I ..i kUaa B .th Bumwimhi of SeireitM^tto. to PtOtOlM* KoM«U Hamilton, a rr.idiute of tlerk>li>) Mtia 9teYt-n*on received hi*r degreo from Stanford with tbe claas ot 190*. *nd In ber undergraduate da>s wai a pOpOsOr inetnti*r ol 0 ■ |" BBI Q rltc t;rov••. -* her** tbey t\- holld.il** Mleaea M*rJ*.rle aod Marlon l-aw- rle. of Alameda, have been visiting for several days at the home of Mra O A. Wright on Wa verify atroet I'ri.fee-i-or 0 H. Clevenger. former huh01 lm in metallurgy at Stanford iniTersttr. t-eares tomorrow for Central America, where he will be occupied for thr-jrv month* with mining 'uvr-atlgatlon- Mt* CtovmgM and the baby will »;-.-nd thi* »lw**r _****■ d V Bahr-eas.'o( Sacramento, ts a iia'tnr at the home of bis nephew C I. Story, on Webtter street, Mr. Story haa been confined to bl* bed for aeveral weeks and U contempt at ■ Ing a trip to the southern pan pf tbo HI*- Ftoreni-'* .Ion-. »I u| Im* Unifflti tit" I her engagetoenl Kee*>, Stanford 02. ol 1 Tenn Since b«f grad' Homier waa for two n ■s. g*-adiiallrx f'*om rtrctrett % arbot rofhtti td CMcssV- Ituli'- and In fiimttntolll tra\*-l. n- titrnlng to CMtOgO wii-n. the togre-3 of I'h Ii was con(.*rri"d njitin biro last y-*ar. He I* *A present so li - l;i tl ■ U«lTI :*•: | ' C :it • > lianU n.«* mair;:...'- Hotae lii-.li-*. Daw t nlirr---.itjr Are-I tree and Ht-poMf* Mm? lit Mud* a j Holt* al I: in...ii.i -**ii> . t t nn ■ Jtoa M«k. tbe Chinese proprietor of the vogeUhle gardens near thc : rutin It i-.-il pumping station, partlci-j lilted iL ,i lively runaway tin Culver-; Ihlty avenue th!-* fore-noon and tin**; ■ t'Minti to return thanks to thr limit i Joaa that bv waa not killed outright, j i While pa**lng tht* California mar* : ket one ot the traces became de- ■ ached and awung down, striking lhe : horse on thn heel* nnd • anting it to (run away. Il daabed up tbe slraot. |Mok dragging on tbe line* with all , his strength, bul to no avail. At ; Ramona street the runaway rig col- Itldod with thi* W'(.-ll^-Fnrgo vipreea ■wnietitt. luaablllQ ihe sheit* snd re j Inoslng the horse, which rontltlued Ita ftighi a short distance until *~ap- tnrs-d by a pedeatrlan j Tbe Chinaman clung to the lines * .t>ugh lt» be Jerked over the t dashboard aod dj?BO-*ttsd lo the di'k pond" which has heen maln- r.ilmtl b] thi' liatuhtitt ionstrurtion ' gang at tht* corner of Ramona atreet since the curve waa tnatalled at that <filace. The water and tnnd seems (bottomless to the avenge pedestrian, I but Mok found something bard with ■hi* bead and emerged btootftal pro- ifusi'l^ Trom a long cut alMiv« the left eye- Ha had atruck one of tho [street car tails lo bl* fall and It I* i re-marlsable tbat his ahull waa not The Injured celestial wa* taken ■ ;ii(* ."tner'a dttig store, where .'hi* InJ'itlea were nilt mlM by "Dot" ' Wludiing and Dr. A. J Vtilian. the flatter taking several nlt.be* to cloae • nd Mok wsa able la make bia way home without a*-xl*tsDce. I In- :*..:iy Timee -10c a weak (Continued from page I.l ature of from 2G lo : * dt-grm** N"umb**ia riished into tht: ftlrvets ID order to permit the snow to fall npon them. While the youngster!* snatched fnintU.ilty at thi- UIIIiik itnki-i In lho hope of :uii.is.*.i ti v. i'Uou„*h for a snowball. All afternoon the hill* MXV dirty htsck with iteoyle cllmimii,- thilr aides to the snow lloe. la ordei to touch, aa well aa set* the unusual •"•iNM-uno. uud a numlier of snow- btill ii.trtie-t. .voro enjoyed, a* waa at- lesivd li. Ihe ahouL, of Istigbter pro- OOOdtaS from some spot where *be aaow bad collected In sunVU-nt quan title* to to-lio tbe an.iis-.ment immui- bia. Th-t> hhot* Mvtni " hav** liet*n general thtotKhout thu rentrul nnd north.-in portUwrt of (he slate. Sunt t Roaa, Nap i. Vallejo, Maryuvllle and Stockton all refort snowfall), aid te»p*raiuree vatying from 2k* to 1 s <l*«Te*-s. Throtfthout the SU-rra* the •tm-afiill tn.tr, .ilinn*! unprt-fOdenlOd. *'■• L'-n .iti-.n Tomorrow. Registration at Stauford tor the ensuing "semester occurs totnorroe-. Dr. Samuel M. Zwrl-ncr, fellow o* tba Itoyal Ot-tigraphlcal Society, of Arabia, will deliver so addreae, "The Moslem World," m*9M W«-dii-*i«ltty In lite t*ha|*l al 3 oVltn-k David Starr Jordan spoke Saturday before thc students' cooleronr-i of tbe Yout g Men s ( btistlan Asaoct- itlon. wturh was In HHlaB during ttif i'..-' •**"!. *i r-i'in. i'.ii.v. iii'i, Jamln Ida WbOOlOT, lui-videttl ot ihu I'ltlvt'islty of Calitornta, was la at- Mateaca at the confi-reoee. *-******** ******** ********* t'HRIHTI IN (HI ltl M \NNl \l, M» I MM. (Continued from paga l > Saturday night, th" pn*lor, Rev. C L. Baal, address-ad -Mutgregstlon briefly, to resume of the work ot the Paat year and upon the promising outlook (or the coming year. Tha aim* of tho congregation aa adopted for ltu7 are ns follows: ISO In the Sunday achool. 150 con- verslonn during tba ytmr. It. in,th< T. P. 8. C K SO In ihe Junior C | 59 as average allendsme at pfPfPK meeting; UQ members of the aid so- ■ it-tv T.o merffb«nt In OK C IT, I- H Auxiliary. -0 Willing Wmlnin ■, )22i***>-^^ Our Great SPECIAL DISCOUNT SALE IS NOW ON i : FOII "11EA|. UVK" **AI,rKS VOI* Mill! I.l. Mn* FAN. T >l \l,l IH II HTOI1K .*. VIHIT I.IIUMJ THR KIXT IIW HI I.l,.. UK 11KTIIIN PAnHH A.M. I.KI.IVKH THK H.H.I.M n\ II IU IIAMKHUF »3.*i OH MOIIK. ..******, /«Tni WHtcntiajna- 6lt7 Nsrth first M. SAN Mil, C*_ TCLCPHONC MAIN ISS k tf-£2*£3^3-**SS----^^ Christian pttptt in "-"'ry home; trvorj* member uttetidlng * hut. li • Miss Alice Spurgeon sung n aa> rred aola, tbe words of which were Ihe composition of Rev. D. A. Itua- sfll. a former Incumbent of tbli t-hsrge. Thn otflccnr idecled for the com*, Ing year ara: Hoard of trustee*. J. A. llntT. I W. Howard, A- W. Mills, Lorento Welch. R. II. Walker J. H. Harding snd Joseph (ioasett Daaconeaaaa, Mra. A N. Mills. Mra. Joseph Oossett ar.d Mra. R. II. Walker aud Mia. J. W. Howard. Rldara, J. A. Huff, Joseph (Ioasett aud A W MHIa Deacon*. Wslk«r. J H Hardla> i. J W. Hot-ward. H. H. II Hardlrf>and ta Welch. ibscrlbt for The Times. B. F. Hkll HI. RlTOHIK Coal Wood Hay Grain U-tMl-Rltchl* CO. rtiooa Main M Corasr imiiwit It. »ad Nstnlltas A* t\ Jamaican I*dy H|i-aks Highly of CTiaaaberlaia's Cough Iteaiedy. Mrs. Michael Hart, wile of tba au- iHtrlntendeot of Cort Service ot Kingston, Jamaica. Waal India la- lands, aaya that aha 'baa (or aomo yeara used Cham bar Iain's Cough Remedy for coughs, croup aad 'hooping cough and haa found I', verr benaflclal. 8ha bu implicit confidence lo II and would oot ba wkhoul it in bar homo. Bold by Bagle Drug Co., C 0. Walter pro- proprietor. ■tot . ee-e-eee-eeee-es-es^eseee Just think! It would pay San Francisco people to buy their dry goods in Palo Alto. Two San Francisco ladies visiting; here, bought heavily at this sale; and why not? The prices are "way below" San Francisco prices. Why? We buy in case lots for four stores, own our own buildiug, and pay minimum insurance rates. HERE'S THE RESULT: 7.50 Ladies* Dress Skirts for . . 1.95 mens department 15.00 Cravenette Coats for . . . 7.45 2.00 Negligee Coat Shirts for . . . UO , . ™ r* r- j a- ,n **50 and 2.00 Stiff Bosom Shirts for . 75c 7f) and 1.00 Dress Goods for . . 3Qc 2 o0 FlanneUette Pajamas for . . . 1.25/ 1.25 Bed Spreads for .... . 85c L50 Boys' Sweaters, to 10 years, . . 75t I FRAZER & CO. Four Stores PALO ALTO <i- *********••********.*****.********** I I
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