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    Purification of tyrosine-phosphorylated proteins by immunoaffinity chromatography and direct cloning of their cDNAs from bacterial expression libraries

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    Growth factor receptors endowed with intrinsic tyrosine-kinase activity (receptor tyrosine kinases, RTKs) are capable of intracellular signal transduction through their ability to autophosphorylate and to phosphorylate cellular proteins, globally referred to as substrates (refs.1–3 and references therein)
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